Eligible investigators can submit an Expression of Interest (EOI) to the online global portal. New users should register for an account before submitting your EOIs.

Once you have established an account, sign into the application portal and select “My Applications” from the top right of the screen. Choose “Available Grants” from the menu on the left and scroll down to GCRFF Multinational Clinical Trials Expression of Interest. Select “Start” to begin an EOI.

You will be asked to provide contact information and your institution details if not already provided in your portal profile. Complete all pages of the submission form and select “Submit Application” on the summary page. Submission receipt will automatically be confirmed by email, and another email will indicate when feedback can be expected.

Eligibility Criteria

Investigators interested in participating in the GCRFF Multinational Clinical Trials Initiative need to meet the following criteria in order to participate:

  • The principal investigator should be a senior researcher working in an established and eligible research institution in a GCRFF member country. They must have a strong track record of grant support and an internationally recognized research profile.
  • The trial should plan to test specific interventions or pathways of care for the prevention, diagnosis or treatment of heart and circulatory diseases. These include drugs, surgery, devices, and psychological, physical and educational interventions.
  • The trial should address an unmet clinical need of importance to people affected by, or at risk of, cardiovascular disease. Its results should have the potential to change clinical practice.
  • There should be a clear need for a multinational trial to answer the clinical question.
  • It should be clear why the trial should be considered for support by the national cardiovascular funders and not by others (e.g., pharma) even though we encourage applicants to explore co-funding beyond the GCRFF members.
  • The trialists should have initiated discussions about the trial with relevant funding bodies in the countries where the majority of participants will be recruited.

Key Deadlines

The advisory committee will review EOIs three times a year. Be sure to submit your EOI proposal prior to these deadlines below in order to be considered for funding. Check back often as new dates will be added once available:

  • May 27, 2022
  • Sept. 30, 2022


Do you still have questions? Email our team at GCRFFclinicaltrials@nih.gov.