The GCRFF Multinational Clinical Trials Initiative is a collaboration between major international funders of cardiovascular clinical research. It provides a way for researchers to submit a single proposal for a multinational cardiovascular trial, for timely consideration by individual research funders. Funders can then decide whether they wish to fund the element of the trial in their jurisdiction, with a full understanding of the wider components of trial design and funding.

The goal is to help researchers in different countries collaborate more effectively and plan ambitious, practice-changing clinical trials that deliver results successfully. The Initiative does this in two ways:

  • It allows individual research funders input into the trial design at the outset rather than after the trial has already started.
  • It reduces the risk to the funder(s) by providing greater assurance that the trial will be deliverable and costs will be shared.

GCRFF and Multinational Clinical Trials Members

GCRFF and Multinational Clinical Trial members include:

The American Heart Association
The British Heart Foundation*
The Danish Heart Foundation
The Dutch Heart Foundation*
The German Centre for Cardiovascular Research*
The Leducq Foundation
The Heart and Stroke Foundation of Canada
The Institute of Circulatory and Respiratory Health...
The National Heart Foundation of Australia*
The National Heart Foundation of New Zealand*
The National Heart, Lung, and Blood Institute*
The Swedish Heart-Lung Foundation

*Multinational Clinical Trials Initiative members

Expert Advisory Panel

Image of three women in a panel discussion in front of audienceThe GCRFF established an Expert Advisory Panel to review and assess application proposals to support multinational clinical trials. The panel, comprised of independent experts appointed by the national funders, provides feedback on the proposals, such as the quality of the proposed research and whether they warrant potential partnership funding. Panel members meet three times a year to review the EOIs in March, July, and November. The panel serves in an advisory capacity only, and final funding decisions rest with the leadership of the relevant national funders.

Disclaimer: The GCRFF Multinational Clinical Trials Initiative provides a mechanism to support better coordination of multinational trial funding decisions. It does not fund trials directly, nor does it guarantee funding by individual funders. Individual members of the Expert Advisory Panel assessing proposals should not be contacted by researchers directly. Not all proposed funders need to be members of the GCRFF.