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March 7, 2017

Media Availability: High number of deaths from heart disease, stroke and diabetes linked to diet

Nearly half of all deaths in the United States in 2012 that were caused by cardiometabolic diseases, including heart disease, stroke and type 2 diabetes, have been linked to substandard eating habits, according to a study published in the March 7 issue of JAMA and funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.

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March 22, 2017 : San Diego Tribune

Researchers funded by NHLBI have discovered a new role for the lungs: making blood. The study, published in Nature, describes how cells in the lungs of mice produce most blood platelets and can replenish blood-making cells in bone marrow. The research team “disrupted some traditional ideas about the pulmonary role in platelet-related hematopoiesis, paving the way for further scientific exploration of this integrated biology,” said Traci Mondoro, NHLBI project officer. 

March 20, 2017 : International Business Times

Scientists partly funded by NHLBI identified two proteins in cancer cells that make them resistant to chemotherapy. They discovered that blocking those proteins during therapy eliminated human leukemia in mice. According to the authors of the study, published in Nature Medicine, this molecular mechanism is present in almost all cancers driven by enzymes known as tyrosine kinases, such as lung, breast, colon and brain tumors. “We anticipate that this study opens a new avenue to develop curative therapy not only for leukemia but solid tumors, as well,” said lead investigator Mohammad Azam, Ph.D.