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NHLBI Small Business Program



The NHLBI Small Business Program enables US-owned and operated small businesses to engage in research and development on innovative and commercially promising products and services to prevent, diagnose, and treat heart, lung, and blood-related diseases and disorders.

Funding for small business research is available through the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) mechanisms. For an overview of these mechanisms, please visit ABOUT THE PROGRAMS. You can also explore current NHLBI SBIR/STTR funding opportunities here.

Staff from the NHLBI Office of Translational Alliances and Coordination (OTAC), are available to advise and mentor NHLBI SBIR/STTR applicants and awardees on matters relating to product development, regulatory affairs, intellectual property, product commercialization, licensing, and strategic partnerships.

We strongly encourage prospective SBIR/STTR applicants to contact us to discuss their planned funding proposals. Please visit OTAC’s website to learn more about the services that our office offers.

Latest Announcements

19th Annual HHS SBIR/STTR Conference

November 7 - 9, Milwaukee, Wisconsin

Register HERE

This conference is relevant to a diverse audience, including biomedical entrepreneurs; principal investigators; grants and contracts administrators; and industry partners and investors.

Top 3 Reasons to Attend:

1.  Meet one-on-one with HHS SBIR/STTR program managers

Over 100 federal staff, including representatives from the National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), Small Business Administration (SBA), Administration for Community Living (ACL), and HHS Office of the Inspector General (OIG) will be holding one-on-one meetings and giving presentations. You will have the chance to get one-on-one feedback about your technology proposal!

2.  Hear from successful HHS SBIR/STTR awardees 

Gain first-hand knowledge from experienced and successful applicants, potential funding partners and companies during interactive workshops and sessions. These sessions include a diverse group of successful awardees, including women-owned small businesses and socially and economically disadvantaged small businesses.

3.  Learn how to develop a competitive application

Many sessions focus on how to develop and submit your SBIR/STTR application. Topics include:

  • How to submit your SBIR/STTR grant proposal electronically via ASSIST
  • FDA regulatory requirements for drugs and devices
  • Important considerations to protect your intellectual property
  • Top 10 Dos and Don’ts for SBIR/STTR proposal development
  • Understanding indirect costs and financial accounting systems
  • What you need to know about human subjects and animal research
  • The differences between SBIR grants and contracts

For more information, please visit Clinical & Translational Science Institute



Get Tips on Your Commercialization Plan and Regulatory Strategy

Watch the NHLBI Small Biz Hangouts. Check out archived presentations


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Last Updated July 2017