When CBS’s 60 Minutes aired the compelling story of a Florida woman whose severe sickle cell disease symptoms were alleviated with a cutting edge gene therapy technique, people listened. A lot of them. The treatment happened at the National Institutes of Health, and since the showcasing of its dramatic success, NIH has been responding to scores of...
Researchers funded by NHLBI have found that anti-inflammatory biologic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition.
Central fat, the one that accumulates around the waist, seems to be a key indicator of higher mortality risk among women who are otherwise considered of normal weight.
Researchers are reporting identification of a possible drug target for treating dilated cardiomyopathy, a potentially deadly condition involving enlargement of the heart’s main pumping chamber.
Wake-up call: High blood pressure and cholesterol in young adults associated with later heart disease
High blood pressure and elevated cholesterol levels in young adults may lead to an increased risk of heart disease later in life, even if they manage to get these levels down later in life, according to a new study.
An NHLBI-funded study showed that high plasma levels of fatty acids found in fish oil were associated with a reduced risk of heart failure over a median follow up period of 13 years.
The majority of nutritional supplements or diets are not linked to longer life or protection against heart disease, according to an analysis of 277 clinical trials using 24 different interventions and totaling 992,129 participants.
An NHLBI-funded study found that asthma outcomes among urban minority children can be worsened by a chaotic, noisy household where it is hard to relax.
Researchers found that the majority of study participants with variations in the DNA sequence for the titin gene did not predict signs of cardiac decline or idiopathic dilated cardiomyopathy (DCM)—a potentially life-threatening condition due to enlarged, weakened ventricles that has no known cause.
An NHLBI-funded study has found that not all sitting is created equal when it comes to increased risks for heart disease.
An older woman’s body shape—that resembles an apple rather than a pear—may point to an increased risk in heart disease, despite having normal weight, a study suggests.
An NHLBI and CDC study shows a strong geographic correlation between the rates of chronic obstructive pulmonary disease (COPD) and current smoking prevalence among adults.
Researchers are reporting the discovery of a possible cell-based therapy that could help stimulate lung development in premature infants with a rare disorder called bronchopulmonary dysplasia (BPD), a condition that can lead to lifelong breathing problems and even death.
Researchers funded by NHLBI have provided evidence to support a simple measurement for diagnosing clinically significant airflow obstruction, the key characteristic of chronic obstructive pulmonary disease (COPD), the fourth leading cause of death in the United States.
In a study that helps highlight the need for diversity in study populations, researchers identified 27 new genomic variants associated with conditions such as blood pressure, type 2 diabetes, and chronic kidney disease in ethnically and ancestrally diverse populations
Study finds no link between red blood cell donor pregnancy history and death in transfusion recipients
A study of more than 1 million transfusion recipients does not suggest an increase chance of death when receiving red blood cells from women with a history of pregnancy.
Researchers found that analyzing social group structures in addition to data from wearable fitness devices can provide a more comprehensive account of health.
Researchers have identified a type of master cell that coordinates the body’s immune defenses in the first days after infection with tuberculosis (TB).
An NHLBI-funded study found that an irregular sleep schedule might lead to metabolic disorders such as obesity, diabetes, high cholesterol, and high blood pressure.
Women in their 70s who walk on average 4,000 steps over the course of a day—roughly two miles—may live longer compared to women who take less steps.
Mobile phone apps and fitness trackers are all the rage, but do they work? A new study indicates that one mobile phone app designed to get sedentary women to move more showed promise in a clinical trial
MESA, Framingham, and Jackson Heart Study data help identify new rare genetic variants linked to diabetes risk
Researchers have identified four genes with rare variants that could affect diabetes risk.
The improvement in cholesterol levels among children and teens in the United States still leaves a half empty glass. There have been hopeful changes, but still 50% of Americans ages 6 to 19 have less than ideal cholesterol levels; and as many as 25% of them are in the clinically high range.
Researchers used a zebrafish model to show that epidermal growth factor receptor, or EGFR, is a third and crucial molecule needed to generate blood stem cells in the laboratory—a process once thought of as only involving two molecules.
A study of nearly 300 patients with mild persistent asthma found that inhaled steroids—long considered the gold standard for asthma treatment—were no more effective than placebo in nearly three-fourths of the study patients, all over age 12.
Two recent NHLBI-funded studies have found a particularly worrisome link between stress and increased risk of cardiovascular disease, which includes heart disease and stroke, in African Americans.
Researchers used specially-designed 3D printing technology to develop an artificial air sac that structurally and functionally mimics similar structures found in the human lung, including the ability to pulsate or “breathe” without bursting. The development represents a step toward the much anticip
Clare M. Waterman, Ph.D., NIH distinguished investigator and director of the NHLBI Laboratory of Cell and Tissue Morphodynamics has been elected to the National Academy of Sciences (NAS), the highest honor for American scholars in recognition of their distinguished and continuing achievements in ori
Despite new technologies existing to discover novel disease biomarkers, many molecular platforms are resource intensive and require rigorous sample collection.
In a new study that links sleep insufficiency to heart disease, researchers are reporting that people who sleep fewer than 7 hours per night have lower levels of certain gene-regulating molecules called microRNAs, which play a role in reducing inflammation and support blood vessel health.
True or false: People can get by on five or fewer hours of sleep.
In the largest study to date to explore how young doctors spend their work day, researchers are reporting that first-year doctors spend almost 90 percent of their time away from patients.
Researchers engineered a new detergent capable of breaking chemical bonds in proteins when exposed to ultraviolet light.
New mouse model could speed development of effective treatments for most common form of heart failure
Researchers are reporting development of a new mouse model that could speed development of effective treatments for the most common form of heart failure.
Targeting a seldom-used DNA repair pathway with gene editing could be a strategy to treat rare diseases
Researchers developed a gene editing strategy to repair parts of the DNA affected by microduplications. These small segments of DNA, when copied or duplicated, can ultimately lead to loss of function of the protein and over 100 different rare diseases.
Genetic and environmental changes that disrupt the circadian rhythm, the body’s 24-hour internal clock that controls the sleep/wake cycle, may reduce the toxicity of a mutant gene for Huntington’s disease, a study in fruit flies found. The study could lead to new therapies for Huntington’s.
A study revealed that certain amounts of glucose, or sugar, is important for the lung immune system to function properly in mice.
Researchers partially funded by NHLBI have discovered that a reaction in the gut informs the brain that it should switch the neurons that indicate thirst on or off.
Researchers funded by NHLBI found that adults with sickle cell disease have worse performance in several cognitive tests than their healthy siblings. The disadvantage remained the same even for the patients treated with hydroxyurea.
Researchers have optimized CRISPR-Cas9 technology, a gene editing approach revolutionizing medical research, to achieve therapeutic editing of the blood stem cell population.
Researchers have developed bioengineered blood vessels that closely mimic the structure and function of human blood vessels and show promise of being safer and more effective than current grafts made of synthetic materials.
Researchers are reporting in animal studies that using a certain drug to target cystic fibrosis (CF) in the womb could prevent damage to organs, including the pancreas and lungs. CF is a life-threatening, multiorgan genetic disorder that causes serious damage to the lungs.
A study partly funded by NHLBI found that more than half of the patients who could be receiving statin therapy but are not, were never offered the option.
Researchers have developed a hand-held device that combines the gene-detecting properties of CRISPR with electronic transistors made of graphene that can detect gene mutations within minutes without the need for DNA amplification.
NHLBI-funded researchers have developed a model of the human respiratory airways that, by mimicking its behaviors, revealed the mechanism of asthmatic bronchial spasms.
Researchers are reporting that drinking sugary beverages like sodas and sports drinks is associated with a greater risk of death from heart disease, especially among women.
An NHLBI-funded study found that the higher the consumption of dietary cholesterol or eggs, the higher the incidence of cardiovascular disease, which includes heart disease and stroke, and death from any cause among U.S. adults.
Compared to drug therapies, catheter ablation, a common cardiovascular procedure, didn’t achieve a significant reduction of strokes, deaths, and other complications in patients with atrial fibrillation.
Women 60 and older can see significant improvements in their heart health from even light physical activity, such as housework, gardening, and leisurely strolls.
Researchers have confirmed that a non-invasive imaging method called parametric response mapping can detect small airway damage in chronic obstructive pulmonary disease, or COPD, on a chest CT scan.
Jennelle Stephenson, 28, who was born with sickle cell disease, shared her experience of recovery after receiving genetic treatment as part of an NIH clinical trial that might hold the key to a cure of this disease.
Permitting first-year doctors to work longer shifts does not create chronic sleep loss or reduce patient safety, according to the results of two large national studies.
A clinical trial partly funded by NHLBI found that integrating behavioral therapy for weight loss and antidepressant medications as needed for patients with co-occurring obesity and depression had a positive effect for both conditions.
Researchers found that combining behavioral weight loss treatment, problem-solving therapy, and as-needed antidepressant medication leads to a significant decrease in weight and depressive symptoms in people with obesity and depression, although the effect is modest.
An increasing number of studies have linked psoriasis, a chronic inflammatory skin disease, to the development of heart disease. Now, a new study provides further evidence for this link by demonstrating how certain blood cells might interact in a way that damages blood vessels in people with this ps
Think sleeping in on the weekend can repair the damage for a week of sleepless nights? Think again. Researchers are reporting that weekend ‘catch-up’ sleep might make things worse, including an increased risk of weight gain.
Researchers are reporting that a protein may be responsible for lipid metabolism, a process that controls the production and breakdown of lipids, or fat molecules, in cells.
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes, but the underlying mechanisms are poorly understood.
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic factors play an important role in COPD susceptibility. Researchers recently performed a genome-wide association study in 35,735 cases and 222,076 controls
Asthma is a complex disease with striking disparities across racial and ethnic groups.
A large NHLBI-funded prospective study of sedentary time and cardiovascular disease in women found that each additional hour/day spent not sitting was associated with a 12 percent lower risk of any cardiovascular disease and a 26 percent lower risk of heart disease in women who were 63-97 years old.
Researchers have identified multiple variations in the DNA that link to how the body regulates and distributes body fat.
Research has shown that cancer cells produce PD-L1 to evade attack from the immune system. Now there is evidence that a similar mechanism may occur in idiopathic pulmonary fibrosis (IPF), a chronic, progressive lung disease that causes buildup of scar tissue in the lungs and prevents oxygen transpor
Researchers are reporting in a new observational study that daily consumption of diet drinks appears to increase the risk of stroke among older women.
T cells are immune cells that are essential for life.
HemoTypeSC, a low-cost and easy-to-use screening test for sickle cell disease was more than 99 percent accurate in detecting the condition in young children.
NHLBI-funded researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity
Researchers are reporting development of a novel strategy for targeting heart disease.
Being a morning person is a behavioral indicator of a person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants, researchers recently increased the number of genetic loci associated with being a morning person from 24 to 351.
An NHLBI-funded study found that persistent racial disparities in asthma can largely be explained by socioeconomic and environmental factors, such as access to healthcare and housing conditions.
Lifestyle and environmental factors play a central role in cardiovascular disease.
Researchers have found that blood is not properly distributed in the brains of sickle cell disease patients despite once thinking that the issue was a reduction in total oxygen to the brain.
Researchers have developed a simple blood test that can detect when a newly transplanted lung is being rejected by a patient, even when no outward signs of the rejection are evident.
The incidence of obesity has reached alarming proportions worldwide, and increasing evidence suggests that the parents’ nutritional status may predispose their offspring to lipotoxic heart disease—the accumulation of fat in heart cells.
Researchers are reporting that consuming high levels of inorganic phosphate, a preservative widely used in certain sodas, packaged meats, and other processed foods, is linked to reduced physical activity levels.
Regular aerobic exercise in combination with a heart-healthy diet appears to reverse some effects of brain aging and might reduce the risk of dementia, according to a new study that reinforces the value of lifestyles changes for keeping both heart disease and dementia at bay.
Black men participating in a blood pressure reduction program implemented in barbershops continued to have significant improvements in their blood pressure in a 12-month follow-up study, according to researchers.
Study sheds light on distribution of Alzheimer’s gene in Latino populations
In a study partly funded by NHLBI, a team of researchers found a 25 percent reduction in the risk of cardiovascular disease among participants who consumed a Mediterranean-type diet rich in plants and olive oil and low in meats and sweets.
Researchers find link between atrial fibrillation and mutations in a gene associated with heart disease
Researchers have discovered a new link between atrial fibrillation (Afib)—a potentially life-threatening condition that causes rapid, irregular heartbeat—and mutations in a gene associated with heart disease.
A team of NHLBI-funded scientists have cut out a segment of cells’ genomes that is the main reason for an increased risk of cardiovascular diseases, which include heart attacks, aneurysms or strokes, according to a study published in Cell.
Researchers have discovered that a type of tiny marine invertebrate has a blood-forming system and an immune system with remarkable similarities to humans
Credit: Jill George, NIH
An NHLBI researcher shared encouraging results from a human clinical trial testing a novel gene replacement therapy in people with severe sickle cell disease.
Researchers funded by NHLBI established that rotating night shift work combined with an unhealthy lifestyle significantly increase the risk of type 2 diabetes in women.
A daily hydroxyurea pill has proven safe and effective for young children living with sickle cell disease in sub-Saharan Africa, where the condition is far more prevalent.
In a new study, researchers recently sequenced genetic data from over 900 people of African descent to construct a more complete collection of DNA data that is missing from the current reference genome, a baseline reference used to study genetic variety among groups of people.
A long-awaited research study funded largely by the NHLBI has produced some of the clearest evidence to date about the usefulness of taking the nutritional supplements vitamin D and fish oil to fight heart disease and cancer.
In October, the NIH convened top sleep scientists for a two-day research conference on sleep and the health of women.
A new NHLBI-funded study showed that a change in the type of breathing tube paramedics use to resuscitate patients with sudden cardiac arrest can significantly improve the odds of survival and save thousands of lives. More than 90 percent of Americans who experience sudden cardiac arrest die before,
A team of researchers partly funded by NHLBI has identified genetic mutations that govern blood cholesterol levels.
There might be a way to get the blood pressure lowering benefits of exercise in pill form, a new study in animals suggests. Researchers showed that by increasing the body's supply of beta hydroxybutyrate, a chemical produced predominantly by the liver, it is possible to regulate high blood pressure
Researchers funded by NHLBI have performed prenatal gene editing to prevent a lethal congenital metabolic disease in mice. The study findings, published in Nature Medicine, offer proof of concept for the possibility of genetic therapies before birth.
Silent heart attacks—also known as unrecognized myocardial infarctions (MI)—that show up only on magnetic resonance imaging (MRI) are associated with an increased risk of death over the long term compared with recognized MI, researchers are reporting.
Researchers say they have discovered a gene mutation that slows the metabolism of sugar in the gut, giving people who have the mutation a distinct advantage over those who do not.
Researchers are reporting that a healthy lifestyle intervention program conducted at a group of black churches appears to lower blood pressure more effectively than a health education program alone.
A new Food-PRICE study partly funded by NHLBI examined the health effects and cost-effectiveness of three policy interventions to incentivize healthier eating in the Supplemental Nutrition Assistance Program (SNAP).
An NHLBI funded study found that more than 70 percent of high school students in the United States get less than 8 hours of sleep per night, falling short of the 8-10 hours they required for optimal health.
The lack of new antibiotics is among the most critical challenges facing medicine.
The mammalian liver possesses the remarkable ability to regenerate after injury, potentially restoring up to 70% of its lost mass and function in just a few weeks.
Researchers are reporting that with proper nutrition guidance it is safe and feasible to restrict weight gain in obese and overweight pregnant women.
Tuberculosis is a significant global health threat, with one-third of the world’s population infected with its causative agent Mycobacterium tuberculosis (Mtb).
The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits.
A protein called sarcolipin protects mice against obesity, according to a recent study. Additional experiments showed that this protein regulates energy metabolism in muscle.
Researchers are reporting a high prevalence of sleep apnea in a large population of African-Americans but note that the majority, nearly 95 percent, were undiagnosed and untreated.
Ventricular tachycardia is a life-threatening fast heart rhythm that occurs frequently in heart attack patients and can lead to sudden cardiac death.
White blood cells such as neutrophils may defend against infection, but they also have destructive properties.
Older patients, women, and racial and ethnic minorities carry a disproportionate burden of heart failure in the general population, but their enrollment in clinical trials has been lower than expected.
Researchers are reporting new insights into the genetic and cellular changes associated with the development of nasal polyps, soft outgrowths that can appear in the nasal passages and sinuses and cause breathing problems and infections.
Researchers partly funded by NHLBI have identified a drug that could treat, and perhaps reverse, pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent. The findings were published in the American Journal of Respiratory Critical Care Medicine.
Researchers are reporting new evidence that surgery to prevent abnormal acid reflux appears promising for slowing the progress of idiopathic pulmonary fibrosis (IPF), an incurable disease that causes scarring of the lungs and often results in death from respiratory failure.
Researchers have found that a group of viruses that cause severe stomach illness—including the one famous for widespread outbreaks on cruise ships— get transmitted to humans through membrane-cloaked “virus clusters” that exacerbate the spread and severity of disease.
During the longest and largest obesity prevention study of its kind, young children and their families in poor communities made some achievable and sustainable behavioral changes, but the results were insufficient to prevent early childhood obesity, researchers say.