The NHLBI launched the Cure Sickle Cell Initiative. The Initiative is an NHLBI-led collaborative research effort that will accelerate the development of gene therapies to cure sickle cell disease. The Initiative will identify and support the most promising gene therapies so they can be safely used in clinical research within five to 10 years. The Initiative aims to transform the lives of people who have sickle cell disease by creating a collaborative, patient-focused research environment. With new advancements in gene therapy approaches, the time is right to push toward cures that are more accessible to the approximately 100,000 Americans, and more than 20 million people worldwide, who have sickle cell disease.