Murine Phenotyping Core

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.

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Research

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.

Testing Areas include the following:

  • Cardiovascular Phenotyping
  • Metabolic Phenotyping
  • Pulmonary Phenotyping
  • Neuromuscular Phenotyping
  • Behavioral Phenotyping
  • Exercise Physiology
  • Advanced Imaging Modalities (whole body high frequency ultrasound imaging, vascular imaging, faxitron x-ray, and CT (coming soon))

Featured Publications

Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging.

Authors: Springer DA, Allen M, Hoffman V, Brinster L, Starost MF, Bryant M, Eckhaus M
Pathobiol Aging Age Relat Dis 2016 Aug 01;4
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Low ambient oxygen prevents atherosclerosis.

Authors: Kang JG, Sung HJ, Amar MJ, Pryor M, Remaley AT, Allen MD, Noguchi AC, Springer DA, Kwon J, Chen J, Park JH, Wang PY, Hwang PM
J Mol Med (Berl) 2016 Mar 01;94(3):277-86
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Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity.

Authors: Kim GY, Lee YM, Cho JH, Pan CJ, Jun HS, Springer DA, Mansfield BC, Chou JY
Hum Mol Genet 2015 Sep 15;24(18):5115-25
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Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.

Authors: Holmström KM, Pan X, Liu JC, Menazza S, Liu J, Nguyen TT, Pan H, Parks RJ, Anderson S, Noguchi A, Springer D, Murphy E, Finkel T
J Mol Cell Cardiol 2015 Aug 01;85:178-82
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SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.

Authors: Tiano JP, Springer DA, Rane SG
J Biol Chem 2015 Mar 20;290(12):7671-84
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Meet the Team

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Danielle Springer, M.D., V.M.D., D.A.C.L.A.M.

Core Director

Danielle Springer, V.M.D., D.A.C.L.A.M., is the director of the Murine Phenotyping Core Facility at the NHLBI.

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Michele Allen

Lab Manager
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Audrey Noguchi

Scientific Support Staff