Computational Biophysics

The Computational Biophysics Section of the Laboratory of Computational Biology is a group of researchers, led by Dr. Bernard Brooks, who use high-performance computing and macromolecular simulation to investigate problems in biophysics and chemistry.

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Research Interests

Research Interests

Dr. Brooks' research group have been involved in CHARMM development and oversight for more than 30 years. His research efforts have involved the development of new methods to assist the interpretation of experiment, for integrating multiple computational models into a single (multiscale) computation, the development of methods for normal mode analysis of large bio-macromolecules, new enhanced sampling methods, new restraint methods, and techniques for finding reaction pathways in complex systems. All of these developments are integrated into CHARMM, a complete tool for complementing and enhancing experimental research.

For more information, visit www.lobos.nih.gov.

Meet the Team

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Bernard Brooks, Ph.D.

Senior Investigator

Bernard Brooks earned an S.B. in chemistry from Massachussets Institute of Technology in 1975 and a Ph.D. in chemistry from University of California, Berkeley in 1979. He did his postdoctoral at Harvard University under the supervision of the Dr. Martin Karplus and he joined the NIH in 1990 as a staff fellow in the Division of Computer Research and Technology at the National Institutes of Health. In 1998 we become the Chief of Molecular Graphics and Simulation Section of the Laboratory of Structural Biology and in 1998 he occupied the position of Chief of the Computational Biophysics Section of the Laboratory of Biophysical Chemistry of the National Heart, Lung and Blood Institute. Since 2005 he is the Chief of the Laboratory of Computational Biology at the NHLBI. In 2008 he received the NHLBI Oustanding Mentor Award and in 2010 he got the NIH Merit Award in recognition of defining the needs of supercomputing power to meet contemporary scientific needs at NIH.

Contact the lab

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Félix Aviat, Ph.D.

Visiting Postdoctoral Fellow
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Phillip Hudson, Ph.D.

Postdoctoral Fellow
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Michael Ghorbani

Visiting Predoctoral Fellow
Jiyeon

Jiyeon Min

Visiting Predoctoral Fellow
samarjeet

Fnu Samarjeet, Ph.D.

Visiting Postdoctoral Fellow
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Andy Simmonett, Ph.D.

Staff Scientist
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Yifan Chen, M.S.

Visiting Predoctoral Fellow
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Qianyi Cheng, Ph.D.

Guest Researcher
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Xiongwu Wu, Ph.D.

Staff Scientist