Laboratory of Genomic Instability and Cardiopulmonary Outcomes

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Jason Wong

Senior Investigator Research Interests

Research Interests
  1. Conduct multidisciplinary epidemiologic studies aimed at explaining the biological mechanisms by which exposures influence cardiopulmonary disease risk and progression in humans, with focus on genomic instability.
  2. Investigate whether the impact of exposures on cardiopulmonary outcomes differ across racial/ethnic groups and by geographic location.
  3. Assess how atmospheric conditions characteristic of climate change affect cardiopulmonary outcomes in humans.

Featured Publications

Alu Retroelement Copy Number and Lung Cancer Risk in the Prospective Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Authors: JYY Wong, R Cawthon, Wm Hu, S Ezennia, SM Gadalla, C Breeze, B Blechter, ND Freedman, WY Huang, HD Hosgood, WJ Seow, BA Bassig, ML Rahman, RB Hayes, N Rothman, Q Lan
Chest 2022 Oct 01;162(4):942-945
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Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin.

Authors: JYY Wong, P Imani, H Grigoryan, BA Bassig, Y Dai, W Hu, B Blechter, ML Rahman, BT Ji, H Duan, Y Niu, M Ye, X Jia, T Meng, P Bin, G Downward, K Meliefste, S Leng, W Fu, J Yang, D Ren, J Xu, B Zhou, HD Hosgood, R Vermeulen, Y Zheng, DT Silverman, N Rothman
Environ Toxicol Pharmacol 2022 Oct 01;95:
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Commute patterns, residential traffic-related air pollution, and lung cancer risk in the prospective UK Biobank cohort study.

Authors: JYY Wong, RR Jones, C Breeze, B Blechter, N Rothman, W Hu, BT Ji, BA Bassig, DT Silverman, Q Lan
Environ Int 2021 Oct 01;155:
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Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

Authors: JYY Wong, HG Margolis, M Machiela, W Zhow, MC Odden, BM Psaty, J Robbins, RR Jones, JI Rotter, SJ Chanock, N Rothman, Q Lan, JS Lee
Environ Int. 2018 Jul 01;116:239-247
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Telomere length, cigarette smoking, and bladder cancer risk in men and women.

Authors: M McGrath, JYY Wong, D Michaud, DJ Hunter, I De Vivo
Cancer Epidemiol Biomarkers Prev. 2007 Apr 01;16(4):815-9
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Meet the Team

Jason Wong

Jason Wong, S.M., Sc.D.

Tenure-Track Investigator

Dr. Jason Wong earned his dual-doctorate in epidemiology and environmental health from the Harvard T.H. Chan School of Public Health in Boston, Massachusetts. He later became a postdoctoral fellow at the Stanford University School of Medicine, where he examined the chronic health effects of secondhand smoke in a multi-ethnic study of women in the United States. Prior to joining ECHB, Dr. Wong was a research fellow at the Division of Cancer Epidemiology and Genetics, National Cancer Institute, where he investigated the influence of occupational/environmental exposure to air pollutants on various biomarkers of genomic instability, with a focus on telomere length, as well as identifying risk factors for lung cancer among special populations (e.g., unique or high-exposure, minority, or geographic location).