Clinical Trials

Are you able to have a magnetic resonance imaging (MRI) scan and want to help people with heart failure? This study is developing new methods for imaging the heart and blood vessels using MRI to improve how healthcare providers diagnose people with heart failure. This study takes place in Maryland and Washington, DC.

Do you have symptoms of a lung disease (such as long-term wet cough, bronchiectasis, or recurrent pneumonia) with no genetic diagnosis? This study aims to develop new ways to diagnose primary ciliary dyskinesia (PCD) or primary immune deficiency (PID), two conditions that can have similar symptoms. Researchers will combine information from genetic testing, lung imaging, and lung function tests to diagnose and tell the difference between these two conditions. Participants in this study must be 5 to 45 years old and must have symptoms of a serious lung disease but no diagnosis. This study is taking place at multiple locations in the United States and in Canada, including the NIH Clinical Center in Bethesda, Maryland.

Are you a male with psoriasis or want to help someone with this condition? This study is exploring whether eating only during certain hours of the day (called time-restricted feeding) can change metabolism and reduce inflammation in the blood of people with mild to moderate psoriasis. To participate in this study, you must be a male between the ages of 18 and 80 with active psoriasis, or be a healthy volunteer. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you an adult who has been exposed to tuberculosis (TB) or wants to help people who have? This study aims to learn how cells within the lungs react when exposed to Tuberculin Purified Protein Derivative, a compound that is commonly used to test for TB exposure. To participate in this study, you must be between the ages of 18 and 64 years old and have either been exposed to TB, but do not have active symptoms, or have never been exposed to TB. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Have you had a genetic test that revealed a change (mutation) in the genes that affect your body's elastic fibers? This study aims to learn more about the impact of changes in connective tissue genes on an individual's overall health. To participate in this study, you or your child must be between the ages of 2 and 100 years old. You must have also had a genetic test that identified changes in a gene that affects elastic fibers (e.g., ELN, LOX, MFAP4, FBLN5 and EFEMP). This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you or your child have severe aplastic anemia? This study tests the safety and effectiveness of two medicines called cyclosporine and eltrombopag in people with severe aplastic anemia. The typical treatment is a combination of three medicines: cyclosporine, eltrombopag, and horse anti-thymocyte globulin. Researchers want to see if starting people at a lower dose of cyclosporine and eltrombopag before giving them horse anti-thymocyte globulin is helpful. Participants in this study must be 4 years or older with severe aplastic anemia. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you a healthy adult who is interested in helping researchers learn about heart disease? This study is testing a new medicine called Fx-5A that may be used to treat inflammation and various heart and blood vessel diseases. Participants will have an infusion of Fx-5A while researchers monitor the electrical activity of their heart using a non-invasive, painless heart test called an electrocardiogram (EKG). To participate in this study, you must not be pregnant or have any heart-related conditions. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you an adult with clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undetermined significance (CCUS)? This study is working with people who have CHIP and CCUS to determine whether they have changes in their genes that raise the risk of atherosclerosis or blood cancers. To participate in this study, you must be at least 18 years old with CHIP or CCUS. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you a healthy adult woman living in Washington, DC, and interested in helping researchers learn about heart disease? This study is exploring differences in stress and exercise habits among women who live in different areas of the city. To participate in this study, you must be a healthy woman between the ages of 19 and 45 living in Washington, DC, wards 3 or 5 with access to a smartphone. This study takes place in Washington, DC, and Maryland.

Are you an adult with chronic lymphocytic leukemia (CLL) who has relapsed despite treatment? This study is testing a medicine called venetoclax that treats CLL. Participants will give blood and bone marrow while taking the medicine to help researchers study genetic changes that may happen during treatment. To participate in this study, you must be an adult with active CLL. This study is located at the NIH Clinical Center in Bethesda, Maryland.