Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 10 out of 34 results
Recruiting
Tennessee
Have you been diagnosed with orthostatic intolerance? This study aims to find out how the body’s regulation of basic functions, such as heart rate and blood pressure, is altered in people who have orthostatic intolerance. This condition, which has an unknown cause, is characterized by a racing heartbeat, dizziness, lightheadedness, and other symptoms that occur when a person stands up. To participate in this study, you must be between 18 and 80 years old and have orthostatic intolerance. This study is located in Nashville, Tennessee.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Iowa
Do you know someone whose child was just born preterm? This study aims to understand why some premature babies have low blood pressure by studying heart and lung changes during the first week of life in preterm babies who do or do not have low blood pressure. Researchers hope the results will improve monitoring of newborns’ blood circulation patterns. To participate in this study, your newborn must have weighed 2.2 pounds or less at birth, be less than 1 week old, and be receiving care in a neonatal intensive care unit. This study is located in Houston, Texas.
Child
Recruiting
Iowa
El objetivo de este estudio es comprender por qué algunos bebés prematuros tienen baja presión arterial mediante el estudio de los cambios en el corazón y los pulmones durante la primera semana de vida en los bebés prematuros que tienen presión arterial baja o no. Los investigadores esperan que los resultados mejoren el monitoreo de los patrones de circulación sanguínea de los recién nacidos. Para participar en este estudio, su recién nacido debe haber pesado 1 kilogramo (2,2 libras) o menos en el nacimiento, tener menos de 1 semana de edad y estar recibiendo atención en una unidad de cuidados intensivos neonatales. Este estudio se lleva a cabo en Houston (Texas).
Child
Recruiting
Tennessee
Do you have low blood pressure due to primary autonomic failure from a medical condition such as Parkinson disease, multiple system atrophy, or pure autonomic failure? Autonomic failure is caused by problems with a part of the nervous system called the autonomic nervous system. People with this condition can suffer debilitating low blood pressure upon standing. This study is testing the use of compression garments compared with a medicine called midodrine to improve blood pressure. To participate in this study, you must be between 18 and 80 years old and have low blood pressure when standing. This study takes place in Nashville, Tennessee.
Adult, Older Adult
Recruiting
Maryland
Do you or your child have sickle cell disease and have a stem cell donor? This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. Participants in this study must be at least 4 years old. This study is located in Bethesda, Maryland.
All Ages
Accepting Healthy Volunteers
Recruiting
Maryland
Do you or your child have sickle cell disease or sickle cell trait? This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and patients who have other red blood cell disorders. To participate in this study, you must be at least 2 years old with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease, including routine follow-up tests and procedures. This study is located in Washington, D.C., and Bethesda, Maryland.
All Ages
Recruiting
Tennessee
Are you between 16 and 20 years old and willing to answer questions about managing your sickle cell disease? This study is investigating the care and quality of life of patients who have sickle cell disease as they transition from pediatric to adult care. To participate in this study, you must be between 16 and 20 years old and be a patient of St. Jude Children’s Research Hospital. This study is located in Memphis, Tennessee.
Child, Adult
Recruiting
Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection? This study is monitoring patients and collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.
All Ages
Recruiting
Maryland
Are you pregnant and willing to donate umbilical cord blood to support future sickle cell disease therapies? This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. To participate in this study, you must be pregnant, 45 years old or younger, and willing to donate umbilical cord blood from your newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. This study is located in Bethesda, Maryland.
Adult
Accepting Healthy Volunteers
Recruiting
Maryland
Do you have sickle cell disease and have not had a blood transfusion in the previous 8 weeks? This study will look at whether a particular gene in people who have sickle cell disease increases the risk for more severe symptoms and complications. To participate in this study, you must be between 18 and 80. This study is located in Bethesda, Maryland.
Adult, Older Adult
Accepting Healthy Volunteers