Clinical Trials

Are you an adult interested in comparing effects of different exercise training on blood pressure? This study aims to compare how different types of exercise can affect blood pressure in African Americans. Participants will do either aerobic activities, focusing on raising their heart rate, or muscle-strengthening resistance activities, focusing on weights, for 24 to 26 weeks. To participate in this study, you must be between 18 and 50 years old, have a sedentary lifestyle and elevated blood pressure, and have been born in the United States to either two African American or two non-Hispanic Caucasian parents. This study is located in Chicago, Illinois.

The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better World Health Organization (WHO) functional class at 12 months after initiation of PAH treatment than therapy with sildenafil alone.

Do you or your child have pulmonary hypertension and want to help research? This study is looking to better understand pulmonary hypertension in children who have this condition. To participate in this study, you or your child must be 21 years old or younger and must have been diagnosed with pulmonary hypertension before the age of 18. This study is located at multiple sites across the United States and Canada, including California, Colorado, Massachusetts, New York, Pennsylvania, Tennessee, and Alberta, Canada.