Clinical Trials

Are you an adult who does not have high blood pressure and is interested in research? This study will investigate how the brain regulates the body’s response to stress and how infection with HIV or pre-hypertension affects regulation. Your heart and brain activity will be measured while you are at rest, during a mentally stressful task, and while you feel angry. The study will also test whether a breathing exercise improves regulation. People with and without HIV and pre-hypertension will be included. To participate in this study, you must be between 21 and 65 years old and not have high blood pressure. This study is located in Miami, Florida.

Have you had a genetic test that revealed a change (mutation) in the genes that affect your body's elastic fibers? This study aims to learn more about the impact of changes in connective tissue genes on an individual's overall health. To participate in this study, you or your child must be between the ages of 2 and 100 years old. You must have also had a genetic test that identified changes in a gene that affects elastic fibers (e.g., ELN, LOX, MFAP4, FBLN5 and EFEMP). This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you have overweight? Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours? This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

The purpose of this research is assess imaging and identification of soft plaque that undergoes large deformations or strain will identify plaque vulnerable to rupture which could lead to 'silent strokes'. Validation of current study results with MRI will foster use of real-time ultrasound (US) strain imaging and strain indices as a screening tool for identifying normal human participants susceptible to increased vascular aging and developing plaque prone to rupture or micro-embolization.

Stroke is a leading cause of death and disability in the United States and around the world. The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered to prevent it.

The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic episodic major strokes but also cognitive impairment.

The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered to prevent it.

Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery.