Clinical Trials

The overall objective of research is to test, adapt, refine and validate the HEMOTAG® system to be used outside the usual medical care environments to reduce hospital readmissions.

Are you an adult with heart failure? A clinical trial is testing if a supplement drink helps people with heart failure. Participants will visit the study site once where they will be served a light breakfast with the study’s supplement drink. Researchers will perform a physical exam and draw blood several times during the visit. The study is taking place in Durham, North Carolina.

Do you want to help find new treatments for heart failure with preserved ejection fraction? This study is testing whether a medicine called spironolactone can help treat heart failure with preserved ejection fraction when paired with the standard treatment. Spironolactone helps to remove excess water and sodium from the body. To participate in this study, you must be between 50 and 99 years old and diagnosed with heart failure with preserved ejection fraction.

Are you an adult with a history of heart failure, or do you just want to help people who do? This study is recruiting people with heart failure and people with normal heart function to explore the role of the gut microbiome in heart and blood vessel function. Participants in this study must be at least 18 years old and willing to provide blood and stool samples. This study takes place in Gainesville, Florida.

Do you have heart failure with preserved ejection fraction (HFPEF)? This study is testing the efficacy of a diuretic medicine called spironolactone that stops your body from absorbing too much salt and keeps your potassium levels from dropping too low. Participants of this study must be between 50 and 99 years old and already taking diuretic medicine. This study takes place in multiple locations across the United States and Sweden.

Do you have overweight or obesity? Researchers are testing whether messages sent through a mobile app can help people lose weight. To participate, you must be 18 to 39 years and own a smartphone with a data and text messaging plan. The study is taking place in Chapel Hill, North Carolina.

Do you have overweight or obesity and are not in a weight management program? This study is investigating whether self-weighing, combined with follow-up encouragement, promotes weight loss and use of weight management resources. To participate in this study, you must be between 18 and 70 and overweight or obese and with weight-related comorbidity (hypertension, type II diabetes, pre-diabetes, dyslipidemia, sleep apnea). This study is located in Gainesville, Florida.

Are you an adult with both asthma and obesity? This study is testing whether a medicine called L-citrulline can help treat asthma and improve lung function in people who have obesity. To participate in this study, you must be 18 to 65 years old and have asthma and obesity. This study takes place in Durham, North Carolina.

Are you an adult who has overweight or obesity and would be interested in a weight-loss study? This study is testing whether a medicine called phentermine is safe and effective for treating obesity over a long period. This study has multiple locations in the United States.

Do you or a loved one have pneumonia? This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels.