Find NHLBI Clinical Trials
Search selected NHLBI-supported ClinicalTrials.gov.and by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at
Showing 1 - 7 out of 7 results
Do you know a newborn or toddler who has severe combined immunodeficiency? This study will test the safety and effectiveness of genetic therapies to treat X-linked severe combined immunodeficiency (SCID-X1), a rare genetic immune disorder. The therapies could be a new approach to treat SCID-X1 in people who do not have a brother or sister to be a donor for stem cell transplant. To participate in this study, the child must be 2 years old or younger. This study is located in Memphis, Tennessee; San Francisco, California; and Seattle, Washington.
Are you an adult who has kidney cancer? This study will test how a new genetic therapy approach works for patients who have kidney cancer. A patient’s white blood cells will be modified in the laboratory using genetic therapies. Patients will receive different doses of their own, modified white blood cells. To participate in this study, you must be between 18 and 70 years old and have a diagnosis of progressive renal cell carcinoma. This study is located in Bethesda, Maryland.
Do you or a child you know have lymphoma? This study is testing a genetic therapy to prevent lymphoma from recurring. Participants in this study must be at least 3 years old and at high risk for recurrent lymphoma as determined by your doctor. This study is located in Chapel Hill, North Carolina.
Do you or your child have a platelet, bleeding, or white blood cell disorder? This study is looking at people who have platelet or other blood disorders. The researchers will use a blood sample to look for problems with platelets and a possible genetic cause in the participant’s DNA or RNA. To participate in this study, you must be a child or adult who either is healthy or has a platelet disorder, coagulation disorder, or white blood cell disorder. This study is located in New York, New York.
Does your infant have a low platelet count? This study is investigating the safety and efficacy of platelet transfusion as a treatment for infants with thrombocytopenia. Researchers are looking at the positive effects of platelet transfusion against the negative effects, such as the release of inflammatory molecules and the formation of blood clots. To participate in this study, your child must be younger than 6 months old and have a low platelet count (less than 100 × 109/L). This study takes place in Boston, Massachusetts.
Does your infant have a low platelet count? This study investigates immature platelet counts as a marker for bleeding risk in newborns with thrombocytopenia, compared with platelet counts alone. Immature platelets are the most recently produced platelets and may be a better marker of platelet production. To participate in this study, you must have a newborn who is less than 32 weeks’ gestational age, has a birth weight greater than 500 grams, and has a platelet count less than 100 × 109/L. This study takes place in multiple locations in the United States, the Netherlands, and Sweden.
Are you an adult with polycythemia vera or thrombocytosis? This study aims to find a new treatment or cure for polycythemia vera and thrombocytosis by locating genes and their changes, or mutations, that may contribute to these disorders. To participate in this study, you must have polycythemia vera with elevated hemoglobin (higher than 18 in men and 16 in women) or thrombocytosis with an elevated platelet count (higher than 450,000). This study takes place in Salt Lake City, Utah.