Clinical Trials

Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. In this clinical trial, researchers are studying the link between hot flashes and cardiovascular disease in women. Participants must be between 40 and 60 years old and must not have cardiovascular disease. The study is taking place in Rochester, Minnesota.

Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.

Have you had a heart attack caused by spontaneous coronary artery dissection (SCAD)? Most patients with SCAD do not have traditional risk factors such as tobacco use, high cholesterol, diabetes, but rather, they the heart attack is caused by other problems with the heart. In this clinical trial, researchers are studying people who have had SCAD to understand what may cause this to happen. The study is taking place in Rochester, Minnesota.

Have you ever had a percutaneous coronary intervention (PCI), which is a procedure used to open clogged coronary arteries? Researchers in this clinical trial are studying the genes of people who have had PCI to learn the best way to prescribe medication after the procedure. Participants must be 18 and must have had PCI and received antiplatelet therapy, like aspirin, following the procedure. The trial is taking place in Gainesville, Florida.

Are you an adult who does not have high blood pressure and is interested in research? This study will investigate how the brain regulates the body’s response to stress and how infection with HIV or pre-hypertension affects regulation. Your heart and brain activity will be measured while you are at rest, during a mentally stressful task, and while you feel angry. The study will also test whether a breathing exercise improves regulation. People with and without HIV and pre-hypertension will be included. To participate in this study, you must be between 21 and 65 years old and not have high blood pressure. This study is located in Miami, Florida.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours? This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Do you have overweight or obesity and are not in a weight management program? This study is investigating whether self-weighing, combined with follow-up encouragement, promotes weight loss and use of weight management resources. To participate in this study, you must be between 18 and 70 and overweight or obese and with weight-related comorbidity (hypertension, type II diabetes, pre-diabetes, dyslipidemia, sleep apnea). This study is located in Gainesville, Florida.

Are you an adult who has overweight or obesity and would be interested in a weight-loss study? This study is testing whether a medicine called phentermine is safe and effective for treating obesity over a long period. This study has multiple locations in the United States.

Are you an adult with sleep apnea, overweight, or obesity, or do you just want to help research? This study is looking at how sleep apnea changes fat tissue in the body. The researchers will examine whether these changes in fat tissue may raise the risk of heart and blood vessel diseases. To participate in this study, you must be between 18 and 60 years old with obstructive sleep apnea and healthy without any chronic diseases. This study takes place in Rochester, Minnesota.