Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies  by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 8 out of 8 results
Recruiting
Massachusetts
Are you scheduled for open-heart surgery for your aortic valve? This study aims to look at changes in inflammation and gene activity while surgery patients are on a heart-lung bypass machine. To participate in this study, you must be at least 20 years old and be scheduled for aortic valve surgery, either with or without coronary artery bypass grafting (CABG). This study is located in Boston, Massachusetts.
Adult, Older Adult
Recruiting
Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery? Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.
Adult, Older Adult
Recruiting
Wisconsin
Do you have a high-risk pregnancy? This study will investigate the use of a non-invasive scan called fetal magnetocardiography to detect potential problems in the fetus in five high-risk pregnancy conditions associated with stillbirth. The scan is normally used to look at fetal heart rhythms. To participate in this study, you must be at least 18 years old and pregnant with one of the following: having a stillbirth in a previous pregnancy, carrying identical twins, or having a fetus that has been diagnosed with major congenital heart disease, fetal hydrops, or fetal gastroschisis. This study takes place in Madison and Milwaukee, Wisconsin.
Adult, Older Adult
Female
Recruiting
Indiana
Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Virginia
Health organizations recommend exercise in an intensity based manner to promote cardiovascular adaptation and prevent disease. Metformin is a common anti-diabetes medication that reduces future type 2 diabetes and cardiovascular disease (CVD) risk. However, the optimal dose of exercise to be combined with metformin for vascular health remains unknown. The purpose of this study is to evaluate whether combining high or low intensity exercise with metformin has the potential to outperform either exercise intensity alone on blood flow across the arterial tree as well as impact insulin action in individuals with metabolic syndrome.
Adult, Older Adult
Recruiting
Virginia
Do you have metabolic syndrome? This trial is testing whether low-intensity exercise or high-intensity exercise works best to lower the risk of heart and blood vessel diseases in people who have metabolic syndrome and are taking a medicine called metformin to treat high blood sugar levels. To participate in this study, you must be between 40 and 80 years old and diagnosed with metabolic syndrome but not type 2 diabetes. This study takes place in New Brunswick, New Jersey.
Adult, Older Adult
Recruiting
South Carolina
Do you or your child have overweight or obesity? This study aims to find effective ways to prevent and treat obesity and metabolic syndrome in African American communities. The study will test the effectiveness of a family-based comprehensive health and fitness programs involving community health workers. Participants must be 12 years old or older and African American and have overweight or obesity. This study takes place in Charleston, South Carolina.
All Ages
Recruiting
Texas
Does your child have higher triglyceride levels but normal cholesterol levels? This study is testing whether a protein supplement called carnitine can help prevent blood vessel stiffness in teenagers who have metabolic syndrome or other risk factors for heart and blood vessel diseases. Participants in this study must be between 13 and 19 years old and have moderate to high blood triglyceride levels but normal blood cholesterol levels. This study takes place in Houston, Texas.
Child, Adult