Clinical Trials

Is your child undergoing heart surgery for congenital heart disease? This study aims to help researchers better understand the developing heart and what controls the strength of its beats by comparing it to adult hearts. Researchers will study small pieces of the heart that are removed as a normal part of surgery or repair for children with congenital heart disease. To participate in this study, your child must be undergoing cardiopulmonary bypass surgery and be 18 years old or younger. The study is located in Atlanta, Georgia.

Do you or your child have a heart defect that requires a procedure called extracardiac conduit–total cavopulmonary connection (EC-TCPC)? This study is evaluating the effectiveness of a new type of graft called a tissue-engineered vascular graft for EC-TPC. Participants of this study will have this procedure and several follow-up assessments with magnetic resonance imaging (MRI) to test the performance of the graft. This study takes place in Columbus, Ohio.

Are you 65 years old or older, and do you have severe primary mitral regurgitation? This condition — also called degenerative mitral regurgitation — happens when there is a problem with the mitral valve itself or its supporting tissue, leading to a leaky valve. This study is comparing the safety and effectiveness of two different ways of repairing the mitral valve: transcatheter edge-to-edge repair and surgical repair. To participate in this study, your healthcare provider must determine that you are a candidate for both mitral valve transcatheter edge-to-edge repair and surgical repair. This study takes place in multiple locations across the United States and Canada.

Have you experienced a cardiac event in the past 6 months? This study assesses the efficacy of combining center-based and remote- or home-based cardiac rehabilitation sessions. Many patients who require cardiac rehabilitation, including those with angina myocardial infarction, heart failure, heart valve disease, and coronary heart (artery) disease, do not complete the necessary amount of rehabilitation sessions when done in a center-based environment. Researchers are investigating whether a combination approach will help. To participate in this study, you must be between 18 and 85 years old. This study takes place in Detroit, Michigan.

Do you have both type II diabetes and obesity? Researchers are studying how exercise and weight-loss affect body fat tissues and cells in the body. Participants must be 18 to 50 years old and be able to do moderately intense physical activity. The study is taking place in Chicago, Illinois.

Do you have high blood pressure, high A1C levels, or have overweight or obesity? Researchers are testing if a program helps increase physical activity for people at risk of cardiovascular disease. Participants will receive remote coaching and wear a physical activity tracker. To join, you must be 40 to 70 years old and can access the internet. The study is taking place in Pittsburgh, Pennsylvania.

Are you a Hispanic father with a child between 5 and 11 years old? If so, would you be interested in learning how to prevent obesity for you and your child? Researchers are studying whether a father-child together program helps Hispanic dads and their children learn and use healthy behaviors to prevent obesity. You may be able to join if you are 65 or younger and have a child who is between 5 and 11 years old. Stepfathers, grandfathers, uncles, or older brothers may be able to join as well. The study is taking place in Houston, Texas.

Do you have overweight or obesity? Researchers are testing whether messages sent through a mobile app can help people lose weight. To participate, you must be 18 to 39 years and own a smartphone with a data and text messaging plan. The study is taking place in Chapel Hill, North Carolina.

Do you live in Appalachian Kentucky? Researchers will be using a phone app and incentives to provide health coaching. Participants will be encouraged to eat more fruits and vegetables and reduce saturated fats and screen time. They will also monitor your physical activity using a motion device and help you become more active. To join, you must be 18 years or older. The study is taking place in Benham, Kentucky.

Is your child 10 to 14 years old? If so, they may be able to join a study where researchers are looking at a way to help kids eat healthier and move more. Participants will go to after-school events and meetings and learn about healthy eating and physical activity. To join, children will need one parent or guardian who can help and do study tasks. The study is taking place in Ann Arbor and East Lancing, Michigan.