Clinical Trials

The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).

Do you have chronic bronchitis and COPD and want to improve treatment? This study will be testing how well a medicine called ivacaftor that is used to treat cystic fibrosis works also to treat symptoms of chronic bronchitis. New research suggests chronic bronchitis may be due to a problem similar to cystic fibrosis. To participate in this study, you must be 40 to 80 years old, have a history of smoking, and have not been diagnosed with asthma or cystic fibrosis. This study will be conducted in Birmingham, Alabama.

Do you live in Appalachian Kentucky? Researchers will be using a phone app and incentives to provide health coaching. Participants will be encouraged to eat more fruits and vegetables and reduce saturated fats and screen time. They will also monitor your physical activity using a motion device and help you become more active. To join, you must be 18 years or older. The study is taking place in Benham, Kentucky.