Clinical Trials

Do you have severe asthma? Researchers in this study are trying to determine if a person's genetic makeup changes how a steroid used to treat asthma affects how well it works. You may be able to participate if you are between 18 and 50 years old. The study is taking place in Indianapolis, Indiana.

Does your child have asthma? Researchers in this study are looking at whether a school-based program that seeks to increase assess to physical activity helps reduces asthma. To participate your child must be between the ages of 5 and 11 and attend kindergarten through 5th grade in a Bronx elementary school. The study is taking place in Bronx, New York.

Are you an adult who has asthma, or are you willing to be a healthy volunteer? This study aims to test a new and less invasive way to look at the levels of a protein called GSNOR in people who have asthma. High levels of this protein can lead to inflammation (swelling) in the airways. Normally, doctors measure GSNOR levels with bronchoscopy (a tube inserted through your mouth into your airways). But this often requires you to be sedated. In the new approach being studied here, you will breathe in a chemical that your body makes, called GSNO. Researchers will look at how much of the chemical is broken down in your breath. This will tell them what your GSNOR levels are. They will compare the levels between people who have asthma and people who do not to see whether the test works. To participate in this study, you should be between 18 and 80 years old and either have been diagnosed with asthma for at least a year or not have asthma and not smoke. This study is located in Cleveland, Ohio.

Are you between the ages of 18 and 50 and diagnosed with Friedreich's ataxia? In this study, researchers are testing a new medication, gene therapy, to treat cardiomyopathy associated with Friedreich's ataxia, and you may be able to participate if you are not taking any corticosteroids or immunosuppressive medications to treat Friedreich's ataxia. This study is taking place in New York City, New York.

Do you have heart failure? In this clinical trial, researchers are using images of the heart and blood tests to learn more about Black and Hispanic patients with heart failure. You may be able to participate if you are at least 60 years old; of Black, Hispanic, or Caribbean origin; and have been diagnosed with heart failure. The study is taking place in locations in Connecticut, Massachusetts, and New York.

Have you been diagnosed with peripartum cardiomyopathy and are within 5 months of your due date? This study is evaluating the effectiveness of a medicine called bromocriptine to treat peripartum cardiomyopathy, or weakness of the heart muscle that occurs during or shortly after pregnancy. To participate in this study, you must be at least 18 years old, diagnosed with peripartum cardiomyopathy, and within 5 months of your delivery date. This study takes place in Pittsburgh, Pennsylvania.

Do you or a loved one have pneumonia? This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels.