Clinical Trials

Do you have severe asthma? Researchers in this study are trying to determine if a person's genetic makeup changes how a steroid used to treat asthma affects how well it works. You may be able to participate if you are between 18 and 50 years old. The study is taking place in Indianapolis, Indiana.

Are you an adult who has asthma, or are you willing to be a healthy volunteer? This study aims to test a new and less invasive way to look at the levels of a protein called GSNOR in people who have asthma. High levels of this protein can lead to inflammation (swelling) in the airways. Normally, doctors measure GSNOR levels with bronchoscopy (a tube inserted through your mouth into your airways). But this often requires you to be sedated. In the new approach being studied here, you will breathe in a chemical that your body makes, called GSNO. Researchers will look at how much of the chemical is broken down in your breath. This will tell them what your GSNOR levels are. They will compare the levels between people who have asthma and people who do not to see whether the test works. To participate in this study, you should be between 18 and 80 years old and either have been diagnosed with asthma for at least a year or not have asthma and not smoke. This study is located in Cleveland, Ohio.

Are you a smoker with COPD who is willing to use an e-cigarette to reduce how much you smoke? If so, you may be able to participate in a study that is trying to learn more about the effect of switching from smoking cigarettes to using e-cigarettes on COPD symptoms. You may be able to participate if you are 21 to 74 years old, have mild to moderate COPD, and are willing to try e-cigarettes to cut back on your smoking. The study is taking place in Hershey, Pennsylvania.