Clinical Trials

Do you have low blood pressure due to primary autonomic failure from a medical condition such as Parkinson disease, multiple system atrophy, or pure autonomic failure? Autonomic failure is caused by problems with a part of the nervous system called the autonomic nervous system. People with this condition can suffer debilitating low blood pressure upon standing. This study is testing the use of compression garments compared with a medicine called midodrine to improve blood pressure. To participate in this study, you must be between 18 and 80 years old and have low blood pressure when standing. This study takes place in Nashville, Tennessee.

Have you had a genetic test that revealed a change (mutation) in the genes that affect your body's elastic fibers? This study aims to learn more about the impact of changes in connective tissue genes on an individual's overall health. To participate in this study, you or your child must be between the ages of 2 and 100 years old. You must have also had a genetic test that identified changes in a gene that affects elastic fibers (e.g., ELN, LOX, MFAP4, FBLN5 and EFEMP). This study is located at the NIH Clinical Center in Bethesda, Maryland.