Clinical Trials

This trial will compare time from randomization to failure of treatment or death from any cause of IST versus URD BMT when used as initial therapy to treat Severe Aplastic Anemia.

Are you scheduled for a stem cell transplant with cord blood? This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.

Do you have obesity and severe asthma. Researchers are looking for participants with obesity or severe asthma who may or may not have the other conditions to see the effect of taking an exercise test on lung function. You must be 18 to participate. The study will take place at the University of California, San Francisco, Airway Clinical Research Center.

Do you have asthma, COPD, or asthma COPD overlap syndrome? This study will look at whether a health coach can help people who have asthma, COPD, or asthma-COPD overlap syndrome with their condition. You will be randomly selected to meet with either a lung specialist alone or a lung specialist and a health coach, who will give you recommendations to improve your care and better manage your condition. To participate in this study, you must be age 18 or older, have asthma or COPD, and not already be seeing a lung specialist. You also must get your care from one of 10 health centers in San Francisco, California. This study is located in San Francisco, California.

Are you an adult who has asthma, or are you willing to be a healthy volunteer? This study is looking at the DNA in airway cells to see how they differ between people who have asthma and people who do not. To get a sample of cells from your airways, you may have a bronchoscopy (a tube inserted through your mouth into your airways). To participate in this study, you must be between 18 and 70 years old, either with asthma or with no history of asthma. This study is located in San Francisco, California.

The goal of this study is to test if acetazolamide can improve sleep apnea, neurocognitive function and quality of life in adults with OSA, and to assess how it does that.

Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive airway pressure (CPAP) via a mask interface. However, this device is not effective or tolerated in all individuals. The goal of this study is to examine whether a medication called acetazolamide can improve SDB, as an alternative to CPAP treatment.

Are you an adult with carotid artery stenosis (CAS)? Researchers in this study want to learn more about the plaque that causes atherosclerosis in patients with carotid artery stenosis. To be in the study, you must be at least 18 years old and will undergo a carotid positron emission tomography (PET)/magnetic resonance imaging exam so researchers can lean more on the new PET imaging approach for risk prediction in these patients. The study is taking place Saint Louis, Missouri, and in Los Angeles, California.

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery? Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.