Clinical Trials

Do you have post-traumatic stress disorder (PTSD) or have experienced a psychosocial trauma, or want to help research? This study uses positron emission tomography/magnetic resonance imaging (PET/MRI) to look at the relationship between psychosocial stress and systemic inflammation/atherosclerosis. This study is located in Boston, Massachusetts, and New York, New York.

Do you have heart failure and feel that your condition is harming your mental and physical well-being? This study is testing the use of an intervention called positive psychology–motivational interviewing (PP-MI). Researchers are exploring whether this 12-week intervention delivered by phone and text message can improve the physical and mental health of people with heart failure. To participate in this study, you must be at least 18 years old. This study takes place in Boston, Massachusetts.

Are you a current patient at Massachusetts General Hospital or Brigham and Women’s Hospital with clinical depression and heart failure or unstable chest pain (called angina)? This study is investigating whether 26 weeks of education and increased monitoring from healthcare managers improves psychiatric and heart symptoms better than self-managed care. This study takes place in Boston, Massachusetts.

Does your infant have a low platelet count? This study investigates immature platelet counts as a marker for bleeding risk in newborns with thrombocytopenia, compared with platelet counts alone. Immature platelets are the most recently produced platelets and may be a better marker of platelet production. To participate in this study, you must have a newborn who is less than 32 weeks’ gestational age, has a birth weight greater than 500 grams, and has a platelet count less than 100 × 109/L. This study takes place in multiple locations in the United States, the Netherlands, and Sweden.

This study is testing whether a new imaging technique can help healthcare providers diagnose venous thromboembolism. To participate in this study, you must be at least 18 years old and diagnosed with venous thromboembolism. This study takes place in Boston, Massachusetts.

Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. To participate in this study, you or your child must be 12 years old or older. This study takes place in multiple locations across the United States.

Are you a woman 18 years old or older who has been diagnosed with LAM? This study is examining whether long-term treatment with medicine called sirolimus can stop lung damage in women who have LAM. This study takes place at multiple locations in the United States.

Are you an adult with obstructive sleep apnea? This study is examining how using continuous positive airway pressure (CPAP) to treat sleep apnea affects a person’s blood oxygen levels, heart rate, and quality of sleep. To participate in this study, you must be between 20 and 80 years old with moderate to severe obstructive sleep apnea. This study takes place in Boston, Massachusetts.

Are you a transportation shift worker? This study is testing new methods to raise awareness about obstructive sleep apnea in this group. The study will test whether personalized messages can help encourage participants to get tested for sleep apnea and to stick to their treatment plans. This study takes place in Boston, Massachusetts.