Clinical Trials

Do you have low blood pressure due to primary autonomic failure from a medical condition such as Parkinson disease, multiple system atrophy, or pure autonomic failure? Autonomic failure is caused by problems with a part of the nervous system called the autonomic nervous system. People with this condition can suffer debilitating low blood pressure upon standing. This study is testing the use of compression garments compared with a medicine called midodrine to improve blood pressure. To participate in this study, you must be between 18 and 80 years old and have low blood pressure when standing. This study takes place in Nashville, Tennessee.

Do you have heart failure with preserved ejection fraction (HFPEF)? This study is testing the efficacy of a diuretic medicine called spironolactone that stops your body from absorbing too much salt and keeps your potassium levels from dropping too low. Participants of this study must be between 50 and 99 years old and already taking diuretic medicine. This study takes place in multiple locations across the United States and Sweden.

Are you an adult with sickle cell disease who doesn't experience pain episodes? This study uses machine learning to identify sickle cell disease patients who may be at increased risk of chronic kidney disease. To participate in this study, you must be between 18 and 65 years old with sickle cell disease and not experiencing any painful episodes. This study takes place in Chicago, Illinois, Winston-Salem, North Carolina, and Memphis, Tennessee.

Do you have low blood pressure due to primary autonomic failure or multiple system atrophy? Autonomic failure is caused by problems with a part of the nervous system called the autonomic nervous system. People with these conditions can suffer debilitating low blood pressure upon standing. This study is testing the use of compression garments to improve blood pressure in people with these conditions. To participate in this study, you must be between 40 and 80 years old and have low blood pressure when standing. This study takes place in Nashville, Tennessee.

Are you older than 40 and have a history of peripheral artery disease (PAD)? This study will examine whether the drug rivaroxaban improves symptoms associated with peripheral artery disease (PAD). To participate in this study, you must be at least 40 years old and have a history of PAD. This study takes place in Nashville, Tennessee.