Kiley In the News
WHAT: The National Institutes of Health is partnering with other Federal agencies to host a national meeting to develop a National Action Plan for Chronic Obstructive Pulmonary Disease, or COPD. The COPD Town Hall Meeting will take place February 29 and March 1 on the NIH campus in Bethesda, Md.
WHAT: Providing extra vitamin D to women during pregnancy raised their vitamin D levels without changing recurrent wheezing rates in their offspring by age 3 years, National Institutes of Health-supported research found. However, in these children, who are at high risk for developing asthma, blood tests showed lower levels of specific antibodies related to allergy development, if their mothers took extra vitamin D, according to results appearing in the Journal of the American Medical Association.
New research by University of Iowa scientists and partially funded by the National Heart, Lung, and Blood Institute shows that cystic fibrosis (CF), a life-shortening, inherited condition that affects about 30,000 Americans, causes a mucus defect that reduces the ability to clear particles and germs out of the airway.
Wake Forest Baptist Medical Center will receive a $7 million, seven-year grant from the National Heart, Lung, and Blood Institute as part of a broader network of research centers that is looking at the prevention and early treatment of acute lung injury.
A team of investigators at The Saban Research Institute of Children's Hospital Los Angeles has been awarded $4 million over five years by the National Heart Lung and Blood Institute (NHLBI) for LungMAP, an atlas of the developing human lung.
Two NHLBI studies have failed to find any benefit for statin therapy in patients with chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS)
Vitamin D supplements do little to help control asthma in people with low Vitamin D levels, a new study found, although they might help cut the level of medication some patients need.
Statin therapy does not prevent exacerbations of chronic obstructive pulmonary disease (COPD) or lower mortality from acute respiratory distress syndrome (ARDS), report two studies that rigorously tested the benefit of the cholesterol-lowering drugs on outcomes in the lung diseases.
The findings from the studies funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health will be presented at the American Thoracic Society (ATS) annual meeting on May 18, with corresponding online publication in the New England Journal of Medicine.
Lack of communication between patients and healthcare providers about COPD remains a major barrier to diagnosing the disease. While awareness is increasing, particularly among smokers, the challenge remains to further educate others about COPD and the available treatments for it.
Apolo Anton Ohno, winner of eight Winter Olympic medals for short-track speedskating, had to first overcome exercise-induced bronchospasm (EIB). The condition is a temporary narrowing of the airways during or after exercise.
Lack of communication between patients and health care providers about chronic obstructive pulmonary disease (COPD) remains a major barrier to diagnosis of this disease, according to the results of a Web-based survey released today by the National Heart Lung, and Blood Institute (NHLBI) of the National Institutes of Health. More Americans, particularly smokers, are talking to their doctor or health care provider about the symptoms of COPD, which is an encouraging sign that awareness efforts are taking hold. Patients and providers, though, can still do more.
The Food and Drug Administration and the National Institutes of Health are awarding millions in funding to create 14 centers to conduct research on tobacco products. The centers can eventually receive more than $273 million over the next five years for research on marketing of tobacco products, adverse health consequences, ways to reduce addiction and toxicity, economics, policies and communications, as well as so-called modified risk tobacco products and electronic cigarettes.
The U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH) today, as part of an on-going interagency partnership, have awarded a total of up to $53 million to fund tobacco-related research in fiscal year 2013 to create 14 Tobacco Centers of Regulatory Science (TCORS). These centers will be coordinated by NIH’s Office of Disease Prevention, and administered by three NIH institutes— the National Cancer Institute, the National Institute on Drug Abuse, and the National Heart, Lung, and Blood Institute.
In a new paper published this week online in Nature, a team from the Perelman School of Medicine shows that the pulmonary vasculature, the blood vessels that connect the heart to the lung, develops even in the absence of the lung. Mice in which lung development is inhibited still have pulmonary blood vessels, which revealed to the researchers that cardiac progenitors, or stem cells, are essential for cardiopulmonary co-development.
The joys of summer can be challenging if your child has asthma, a common but serious chronic disease. The NHLBI has tips on how to manage this condition.
NHLBI-supported researchers at Boston University School of Medicine have pinpointed a genetic signature for chronic obstructive pulmonary disease (COPD) from airway cells harvested using a minimally invasive procedure.
An experimental method can distinguish between different types of chronic obstructive pulmonary disease (COPD) and track disease progression. The method may eventually lead to more accurate diagnoses and more effective treatments for COPD, a lung disease that makes it hard to breathe.
The age-adjusted prevalence of chronic obstructive pulmonary disease (COPD) varies considerably within the United States, from less than 4 percent of the population in Washington and Minnesota to more than 9 percent in Alabama and Kentucky. These state-level rates are among the COPD data available for the first time as part of the newly released 2011 Behavioral Risk Factor Surveillance System (BRFSS) survey.
Awareness of chronic obstructive pulmonary disease (COPD) has been rising gradually in recent years, but the results of a national survey show current awareness levels have returned to those of 2008. The survey was released today by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.
Researchers will study pre-symptomatic lung disease in infants and young children with cystic fibrosis (CF), under a new grant program of the National Heart, Lung, and Blood Institute (NHLBI). Results could reveal how CF develops, which in turn could lead to interventions that delay or prevent disease progression. The studies also could provide critical information to help resolve competing theories on the origin and progression of CF-associated abnormalities.
Just as in other fields, scientific diversity has been and continues to be critical for the success of HLB research.
A study comparing three common approaches to periodically adjust the dosage of inhaled corticosteroids (ICS) for people with mild asthma has found no detectable differences in how often a person’s asthma worsened. The methods examined in this study were a patient-guided modification based on symptoms, an assessment made by an examining physician, or the results of a breath test to measure inflammation.
When it comes to adjusting the dose of inhaled corticosteroids for better asthma control, periodic physician assessment was as good a gauge as using a biomarker or day-to-day symptom occurrence, researchers found.
Steroid medications taken for asthma can cause growth to slow in children who have not reached puberty. Is this lasting, or might the children catch up by the time they reach their adult height?
Adults who had been treated previously with the inhaled corticosteroid budesonide as part of a children’s clinical study were, on average, about half an inch shorter than their study counterparts who were not treated with inhaled corticosteroids, according to research funded by the National Institutes of Health. The half inch difference had been observed when the study participants were children, showing that, while the effect on height does not go away, it also does not get worse, the researchers say.
This editorial examines the diversity of topics and mechanisms in the NHLBI portfolio.
Researchers at Weill Cornell Medical College were awarded a $6.5 million grant from the National Heart, Lung, and Blood Institute for a five-year investigation into metabolic changes occurring within airway epithelial cells in the lungs of chronic obstructive pulmonary disease (COPD) patients caused by cigarette smoking.
Adding the acid reflux drug lansoprazole to a standard inhaled steroid treatment for asthma does not improve asthma control in children who have no symptom of acid reflux, according to a new study funded in part by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. Lansoprazole therapy slightly increased the risk of sore throats and other respiratory problems in children, however.
Respiratory diseases remain a major public health problem in the United States and worldwide, with increasing morbidity and mortality. Substantial progress has been made to advance understanding of the basic mechanisms of lung disease and to optimize clinical management of patients with a range of respiratory diseases.
The NHLBI's Dr. Kiley underscores the importance of continued research into COPD (chronic obstructive pulmonary disease), the third leading cause of death in the U.S. "We've laid out a vision, set goals, and are pushing for better understanding," Dr. Kiley said. "In the past, there wasn't too much in the medical toolbox for COPD. That is unacceptable; that has to be turned around."
Translational research in lung disease is paying off. In just the past decade, for example, research has led to a new therapy for lymphangioleiomyomatosis, which may also halt progression of this rare lung disease virtually unknown 15 years ago.
Scientists funded by the National Institutes of Health have identified a common genetic variant associated with substantially increased risk of developing pulmonary fibrosis, a debilitating and life-threatening lung condition. The genetic variant is found in a region of DNA thought to regulate the production of an important mucus-forming protein.
Nine state and local organizations will receive a total of $383,000 for chronic obstructive pulmonary disease (COPD) education initiatives, the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, announced today.
The number of Americans who report being aware of chronic obstructive pulmonary disease, or COPD, increased by 4 percentage points between 2008 and 2010, but many people at risk are still unaware of the disease, according to mailed survey results released today by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.
A new study has found the addition of long-acting beta-agonist therapy to be the most effective of three step-up, or supplemental, treatments for children whose asthma is not well controlled on low doses of inhaled corticosteroids alone.
A new study involving data from more than 20,000 individuals has uncovered several DNA sequences linked to impaired pulmonary function. The research, an analysis that combined the results of several smaller studies, provides insight into the mechanisms involved in reaching full lung capacity. The findings may ultimately lead to better understanding of lung function and diseases like asthma and chronic obstructive pulmonary disease (COPD), the fourth leading cause of death in the United States.
A commonly used treatment for acid reflux does not improve asthma symptoms or control in patients who do not have symptoms of gastroesophageal reflux (GER), according to a new study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health and by the American Lung Association (ALA). This suggests that silent GER (acid reflux that causes only minimal or no reflux symptoms) does not play a role in asthma, as has previously been thought.
On this World Asthma Day, we at the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID), parts of the National Institutes of Health (NIH), stand side-by-side with scientists, policymakers, patient advocates, health care providers, and patients across the country to renew our dedication to understanding the causes of asthma, finding better treatments and promoting better asthma control.
Risk for developing asthma is linked to variants in a gene called CHI3L1, which can be measured by checking levels of an inherited blood protein regulated by that gene, according to new research sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.
The National Heart, Lung, and Blood Institute (NHLBI), one of the National Institutes of Health (NIH), and the Centers for Medicare & Medicaid Services (CMS) are launching the largest randomized clinical trial of the effectiveness and safety of long-term, home oxygen therapy for COPD (chronic obstructive pulmonary disease). The six-year, $28 million project will study patients with moderate disease.
New research suggests that inhaling hypertonic saline, a water-based concentrated salt solution, could provide long-term benefits for lung health in patients with cystic fibrosis (CF). Researchers at the University of North Carolina (UNC) at Chapel Hill tested the effects of inhaling the saline four times daily for 14 days in 24 older patients with CF (ages 14 years or older). The treatment significantly improved mucus clearance, lung function, and breathing symptoms. If confirmed, the findings could lead to a new and inexpensive treatment for CF.
Some adults with mild persistent asthma may be able to adequately control their asthma by taking corticosteroids only when needed, instead of taking anti-inflammatory medication daily, according to new results from the Improving Asthma Control Trial (IMPACT).
The nation's leading asthma clinicians, researchers, and public health experts will present the latest scientific advances in asthma prevention and control at a national conference June 19-21 at the Marriott Wardman Park Hotel in Washington, D.C. Conference highlights include reports on novel approaches for treating asthma attacks, environmental triggers of asthma attacks, the health effects of outdoor air pollution, innovative and effective community programs, and creative ways to educate patients.
Ever wonder why you sleep, or why you don't do your best when you don't get enough sleep? Biomedical researchers have only recently begun to understand how important sleep is to human health and functioning. Now, the latest, most accurate information on sleep and sleep disorders is available online.
The National Heart, Lung, and Blood Institute of the National Institutes of Health today announced that a large clinical trial of mechanical ventilator use for intensive care patients with Acute Respiratory Distress Syndrome (ARDS) has been stopped early. The decision was recommended by the study's Data Safety and Monitoring Board (DSMB) on March 10, 1999, based on data on the first 800 patients which showed approximately 25 percent fewer deaths among patients receiving small, rather than large, breaths of air from a mechanical ventilator.
Physicians who want to provide the most up-to-date diagnostic and treatment methods for their asthma patients can now find, on one online site, virtually all the scientific literature on chronic asthma that has ever been published. The new web site is the Asthma Management Model System (AMMS), launched today by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institues of Health in recognition of World Asthma Day.