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Novel Retinal Biomarkers for Hypertension and Cardiovascular Disease

October 13 - 14, 2022
Virtual Zoom Workshop
12:00 PM – 4:30 PM ET

Description

Emerging evidence suggests a close relationship between the shape and diameter of the eye’s retinal vessels, and hypertension and cardiovascular disease (CVD). Beyond observational studies, little is known about how these retinal blood vessels change as a result of these health conditions. Genetic disease indicators (known as biomarkers) and retinal vessel imaging could offer ways to improve how we diagnose and manage hypertension, heart failure, peripheral arterial disease, and vascular dementia. The presence of hypertensive or diabetic retinopathy may also help detect the risk of CVD, congestive heart failure, or organ damage.

To explore these connections and review the state of the science, the NHLBI Division of Cardiovascular Sciences will host a virtual workshop that brings together experts in hypertension, vascular biology, heart disease, dementia, ophthalmology, neurology, imaging, genetics, data science, and more. Experts will explore retinal imaging biomarkers for hypertension, heart disease, peripheral arterial disease, and vascular dementia; discuss technological advances; share machine learning innovations and artificial intelligence techniques; and identify research gaps and opportunities.

This workshop is open to the public. Learn more and register.

Agenda

12:00 – 12:25 p.m.
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Welcoming Remarks and Meeting Overview

12:00 – 12:05 p.m.
Introduction
Young S. Oh, Ph.D., Program Officer, Division of Cardiovascular Sciences (DCVS), NHLBI, NIH

12:05 – 12:15 p.m.
Welcome
David C. Goff, M.D., Ph.D., Director, DCVS, NHLBI, NIH

12:15 – 12:25 p.m.
Goals and Session Overview
Workshop Co‐Chairs: Emily Y. Chew, M.D., National Eye Institute (NEI), NIH, and Stephen A. Burns, Ph.D., Indiana University

12:25 – 2:15 p.m.
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Session 1: Retinal Vascular Abnormalities in Human Diseases

Moderator: Maria Grant, M.D., University of Alabama at Birmingham

12:25 – 12:55 p.m.
Keynote: Application of Retinal Images in Human Diseases
Emily Y. Chew, M.D., NEI, NIH

12:55 – 1:10 p.m.
Noninvasive Imaging of the Eye for Cardiovascular Disease
Mathieu Bakhoum, M.D., Yale University

1:10 – 1:25 p.m.
Retinal Imaging and CVD
Wilson Tang, M.D., Lerner Research Institute

1:25 – 1:40 p.m.
Age‐related Changes in Human Retinal Microvasculature
Yuen Ping Toco Chui, Ph.D., Icahn School of Medicine at Mount Sinai

1:40 – 1:55 p.m.
Imaging the Retinal Vasculature and Challenges in Human Diseases
Stephen A. Burns, Ph.D., Indiana University

1:55 – 2:15 p.m.
Panel Discussion

2:15 – 2:25 p.m.
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Break

2:25 – 3:30 p.m.
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Session 2: Retinal Biomarkers for Hypertension

Moderator: Wilson Tang, M.D., Lerner Research Institute

2:25 – 2:40 p.m.
Retinal Vessel Analysis in Cardiovascular Prevention: Focus on Hypertension
Henner Hanssen, M.D., University of Basel, Switzerland

2:40 – 2:55 p.m.
Retinal Vasculature, Arterial Stiffness, and High Blood Pressure
Alicja R. Rudnicka, Ph.D., St. George’s University of London, UK

2:55 – 3:10 p.m.
New Methods to Study Retinal Vasculature in Hypertension
Damiano Rizzoni, M.D., University of Brescia, Italy

3:10 – 3:30 p.m.
Panel Discussion

3:30 – 4:30 p.m.
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Session 3: Privacy and Bioethical Issues in Retinal Biomarkers

Moderator: Emily Y. Chew, M.D., NEI, NIH

3:30 – 3:45 p.m.
Confidentiality/Privacy Issue in Retinal Imaging Data
Joel Schuman, M.D., New York University

3:45 – 4:00 p.m.
Retinal Imaging: Ethical Considerations
Holly Taylor, Ph.D., M.P.H., NIH Clinical Center

4:00 – 4:30 p.m.
Panel Discussion

4:30 p.m.
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Adjourn

12:00 – 12:05 p.m.
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Welcome and Session Overview

Workshop Co‐Chairs: Emily Y. Chew, M.D., NEI, NIH, and Stephen A. Burns, Ph.D., Indiana University

12:05 – 1:10 p.m.
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Session 4: Retinal Biomarkers for Heart Disease

Moderator: Rebecca F. Gottesman, M.D., National Institute of Neurological Disorders and Stroke (NINDS), NIH

12:05 – 12:20 p.m.
Optical Imaging and Heart Failure
Aaron Aguirre, M.D., Ph.D., Harvard University

12:20 – 12:35 p.m.
Predicting Myocardial Infarction Through Retinal Scans
Alejandro F. Frangi, Ph.D., University of Leeds, UK

12:35 – 12:50 p.m.
Potential Retinal Biomarkers in Heart Failure
Sara Seidelmann, M.D., Ph.D., Columbia University

12:50 – 1:10 p.m.
Panel discussion

1:10 – 2:15 p.m.
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Session 5: Retinal Biomarkers for Peripheral Vascular Disease (PAD)

Moderator: Christopher Kramer, M.D., University of Virginia

1:10 – 1:25 p.m.
PAD and Retinopathy
Joshua A. Beckman, M.D., Vanderbilt University

1:25 – 1:40 p.m.
Retinal Imaging and PAD
Robert P. Finger M.D., Ph.D., University of Bonn, Germany

1:40 – 1:55 p.m.
Arterial Stiffness and Retinal Biomarkers
Michelle Meyer, Ph.D., University of North Carolina

1:55 – 2:15 p.m.
Panel Discussion

2:15 – 2:25 p.m.
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Break

2:25 – 3:30 p.m.
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Session 6: Retinal Biomarkers for Vascular Dementia

Moderator: Michelle Meyer, Ph.D., University of North Carolina

2:25 – 2:40 p.m.
Retinal Microvascular Abnormalities and Cognitive Impairment (ARIC Study)
Rebecca F. Gottesman, M.D., NINDS, NIH

2:40 – 2:55 p.m.
Eye Determinants of Cognition Study
Alison Abraham, Ph.D., University of Colorado

2:55 – 3:10 p.m.
Eye and Dementia
Cecilia Lee, M.D., University of Washington

3:10 – 3:30 p.m.
Panel Discussion

3:30 – 4:30 p.m.
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Session 7: Gaps and Future Directions

Workshop Co‐Chairs: Emily Y. Chew, M.D., NEI, NIH, and Stephen A. Burns, Ph.D., Indiana University

4:30 p.m.
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Closing and Next Steps

Young S. Oh, Ph.D., Program Officer, DCVS, NHLBI, NIH