NHLBI’s 2021 Annual Sickle Cell Disease Research Meeting
Description
The 2021 NHLBI Annual Sickle Cell Disease Research Meeting is a 3-day meeting that provides a forum for investigators, practitioners, and interested health care providers to discuss the progress of ongoing clinical trials, hear presentations about new developments in scientific and clinical aspects of sickle cell disease, and interact with other investigators and NHLBI program staff. This year’s program includes five symposia that cover a broad range of topics.
Agenda
10:00 am - 10:05 am
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Welcome and Announcements
W. Keith Hoots, M.D., National Heart, Lung and Blood Institute
10:05 am - 12 pm
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SYMPOSIUM 1
10:05 am - 11:00 am
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Sickle Cell Disease and CardiovAscular Risk-Red Cell Exchange Trial (SCD-CARRE)
Mark T. Gladwin, M.D., University of Pittsburgh
Darrell J. Triulzi, M.D., University of Pittsburgh
10:03 am - 11:00 am
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ASH Research Collaborative: Accelerating SCD Research and Enhancing Care
Charles Abrams, M.D., University of Pennsylvania School of Medicine
Kathleen Hewitt, DNP, CPHQ, AACC, RN, American Society of Hematology
11:00 am - 11:30 am
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Biomarkers in SCD with a Focus on Risk Stratification Therapy, Selection Therapy, Monitoring and Prediction of VOC
Patrick Hines, M.D., Wayne State University School of Medicine
11:30 am - 12:00 pm
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Lifetime Medical Costs Attributable to SCD Among Non-Elderly Individuals with Commercial Insurance
Kate M. Johnson, Ph.D., University of Washington
12:00 pm - 1:30 pm
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An Update on the Sickle Cell Trevor Thompson Transition Project (ST3P-UP)
Chair: Ifeyinwa (Ify) Osunkwo, M.D., M.P.H., Medicine Levine Cancer Institute
12:00 pm - 1:30 pm
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Community Health Workers and mHealth for SCD Care
Kim Smith-Whitley, M.D., University of Pennsylvania
12:00 pm - 1:30 pm
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Understanding Transition From Inside the Fishbowl
Raymona H. Lawrence, Dr.P.H., M.P.H., Georgia Southern University
1:30 pm - 2:00 pm
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LUNCH
2:00 pm - 5:00 pm
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SYMPOSIUM 2
2:00 pm - 3:00 pm
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Role of Erythrocyte Mitochondrial Retention in the Pathophysiology of Sickle Cell Diseases
Angela Rivers, M.D., University of California
Automated Red Blood Cell Exchange: Optimal Transfusion Strategy for Disease Control and Iron Management
Shannon Kelly, M.D., University of California
Quantifying Binding Capacity of Plasma for Heme and Measurements of Heme Scavenger Proteins
Madhav Vissa, M.D., University of California
The Role of Spla2 in the Pathogenesis of Inflammatory Diseases: Its Predictive Value and Link to Novel Therapy (SCD, COVID-19, MIS-C)
Frans Kuypers, Ph.D., UCSF Benioff Children's Hospital Oakland
3:00 pm - 5:00 pm
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Curative Therapies for SCD- I (Hematopoietic Stem Cell Transplant)
Chair: Lakshmanan Krishnamurti, M.D., Children’s Healthcare of Atlanta/Emory University
Speakers TBD
10:00 am - 10:05 am
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Welcome and Announcements
10:00 am - 1:00pm
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SYMPOSIUM 3
10:05 am - 10:30 am
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Magnetic Characterization of Normal and SCD RBCs: Potential for Diagnosis and Separation
Jeffery Chalmers, M.D., Ohio State University
Payal Desai, M.D., Ohio State University
10:30 am - 11:00 am
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Microfluidic Studies on SCD: Damage Accumulation Related to Repeated Hypoxia Cycles
Ming Dao, Ph.D., Massachusetts Institute of Technology
11:00 am - 12:00 pm
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Stride-2 Investigator Meeting (by Invitation only)
Shannon Smith, M.D., Emory University
11:00 am - 1:30 pm
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Curative Therapies for SCD- II (Gene Therapy/Editing)
Chair: Punam Malik, M.D., Cincinnati Children’s Hospital
Results from the ongoing LentiGlobin Gene Therapy for SCD Study HGB-206
Richard A. Colvin, M.D., Ph.D., Bluebird Bio
Post-Transcriptional Silencing of BCL11A as an Effective Genetic Treatment in SCD
David A. Williams, M.D., Boston Children’s Hospital and Harvard Medical School
Genetic Therapies for SCD: Disease Amelioration with Reduced Intensity Conditioning – an Update on the Momentum Study, and A Brief Introduction to Gene Editing
Punam Malik, M.D., Cincinnati Children's Hospital and University of Cincinnati
Progress Advancing Autologous Genome Edited HSC Therapies for SCD
Shengdar Tsai, Ph.D., St. Jude’s Children’s Research Hospital
CRISPR-Cas9 Corrected Hematopoietic Stem Cells for SCD
Mark Walters, M.D., University of California, San Francisco
1:30 pm - 2:00 pm
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LUNCH
2:00 pm - 5:00 pm
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SYMPOSIUM 4
2:00 pm - 5:00 pm
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Transformative Technology for Pain in SCD
Chair: Kalpna Gupta, Ph.D., University of California
Miniaturized, Wireless Electronic, Optoelectronic and Microfluidic Systems for Small Animal Studies
John A Rogers, Ph.D., Northwestern University
Microglia-like Cell-Based Assay for Drug Discovery in SCD
Vivien Sheehan, M.D., Ph.D., Emory University School of Medicine
Quantifying and Treating SCD Pain Using qEEG and Transcranial Focused Ultrasound Neuromodulation
Bin He, Ph.D., Carnegie Mellon University
Development of qEEG Algorithms for Objective Pain Assessment
Jonathan Mille, M.S.E., Lead A.I. Software Engineer, PainQx
AI-aided Gait Analysis as an Indicator of Pain
Stacy Kiven, University of California
4:00 pm - 4:30 pm
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Approaches to Effective Therapeutic Management of Pain for People With SCD
Wally Smith, M.D., Virginia Commonwealth University
4:30 pm - 5:00 pm
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Pain Management in Adolescence and Pregnancy, Neonatal Abstinence Syndrome
Chair: Andra H. James, M.D., M.P.H., Duke University
Deva Sharma, M.D., M.S., Vanderbilt University Medical Center
Lydia Pecker, M.D., Johns Hopkins University
10:00 am - 10:05 am
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Welcome and Announcements
10:05 am - 3:30 pm
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SYMPOSIUM 5
10:05 am - 10:35 am
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Ex-Vivo Perfusion of Human Spleens With Red Blood Cells from SCD Patients to Explore The Mechanisms Of Spleen-Related Complications
Abdoulaye Sissoko, Ph.D., University of Paris
Computational Investigation of How the Spleen Reshapes and Retains Young and Old Red Blood Cells and its Implications in SCD
He Li, Ph.D., Brown University
Zixiang Liu, Ph.D., Brown University
George Karniadakis, Ph.D., Brown University
10:35 am - 11:05 am
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Clinical Microfluidic Biomarker Assays for Red Cell Health and Blood Rheology
Jane Little, M.D., Case Western University
11:05 am - 11:30 am
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What’s New With Arginine Therapy in SCD
Claudia R. Morris, M.D., FAAP, Emory University School of Medicine and Children’s Health Care
11:30 am - 12:00 pm
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LUNCH
12:00 pm - 12:30 pm
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Painimation, a Novel Method for Assessing Pain in Sickle Cell
Charles Jonassaint, Ph.D., University of Pittsburgh
12:30 pm - 1:00 pm
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The Role of Neural Mediated Vasoconstriction in the Pathophysiology of Sickle Vaso-Occlusive Crisis
Thomas D Coates, M.D., University of Southern California Keck School of Medicine
1:00 pm - 4:00 pm
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The National Alliance of Sickle Cell Centers Symposium
National Alliance for Sickle Cell Centers Vision and Initiatives
Chair: Julie Kanter, M.D., University of Alabama, Birmingham
How Sickle Experts Define Comprehensive Care for Children
Deepa Manwani, M.D., Children's Hospital at Montefiore
Keynote – Understanding Quality Improvement: Cystic Fibrosis Model
Mike Powers, M.D.
GRNDaD and the Use of Big Data in SCD
Sophie Lanzkron, M.D., M.H.S., Johns Hopkins School of Medicine
Patient Reported Outcomes: How to Move Them into Routine Clinical Care
Marsha Treadwell, Ph.D., UCSF Benioff Children's Hospital
Using Surveillance Data to Demonstrate Where Sickle Expert Care is Needed
Susan Paulukonis, M.A., M.P.H., Public Health Institute
2:00 pm - 5:00 pm
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Annual Sickle Cell Adult Provider Symposium
Chair: John Strouse M.D., Ph.D., Duke University School of Medicine
Co-Chair: Susanna Curtis, M.D., Ph.D., Montefiore Medical Center
Disease Modifying Therapy for Adults With Sickle Cell Disease: What and When to Choose
Susanna Curtis, M.D., Ph.D., Duke University School of Medicine
Best Practices in Current Therapeutic and Curative Options
Ross Fasano, M.D., Emory University
Sophie Lanzkron, M.D., Johns Hopkins University
Debates on New Therapeutic Agents: Which to Use and When
Marquita Nelson, M.D., Methodist University Hospital
Modupe Idowu, M.D., University of Texas Health Science Center at Houston
Fuad El-Rassi, M.D., Emory University
Foluso Ogunsile, M.D., University of Alabama, Birmingham