NEWS & EVENTS
Graphic illustration of lungs with gears inside.

How Can We Use Bioengineering Approaches to (Re)Build a Lung?

December 16 - 17, 2021
Virtual Workshop

Description

NHLBI hosted a virtual workshop called, “How Can We Use Bioengineering Approaches to (Re)Build a Lung?,” on Dec. 16-17, 2021. The goal was to identify critical elements for building and repairing the lung through bioengineering. Workshop participants evaluated current models of human lung biology and their utility for studying physiology, regeneration, and disease pathogenesis, progression, and intervention.

Individuals who require reasonable accommodation to participate in this event should contact Myesha Macdonald at NHLBIWorkshopSupport@nih.gov and/or the Federal Relay (1-800-877-8339). For programmatic questions, contact Sara Lin at 301-827-7839 or sara.lin@nih.gov.

Agenda

9:30-9:45 a.m.
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Welcome Address and Meeting Logistics

Jim Kiley, Ph.D, Director, Division of Lung Diseases, NHLBI, NIH
Sara Lin, Ph.D, Program Director, NHLBI, NIH

9:45-10:00 a.m.
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Welcome from Chairs and Charge for Workshop

Workshop Co-Chairs:
Gordana Vunjak-Novakovic, Ph.D., Professor, Columbia University
Jason Spence, Ph.D., Professor, University of Michigan

10:00-11:15 a.m.
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Session 1: Biological Foundations for Lung Regeneration

Session Chair: Jay Rajagopal, M.D., Professor at Harvard Medical School

  • Mark Krasnow, M.D., Ph.D., Professor of Biochemistry, Stanford Medicine
  • Celeste Nelson, Ph.D., Wilke Family Professor in Bioengineering and a Professor of Chemical & Biological Engineering and Molecular Biology at Princeton University
  • Sara Prescott, Ph.D., Assistant Professor at Massachusetts Institute of Technology (MIT) in the Department of Biology
  • David Lagares, Ph.D., Director, Matrix and Mechanobiology Program, Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Assistant Professor of Medicine, Harvard Medical School
  • Jason Spence, Ph.D., Professor, University of Michigan

11:15 a.m. - 12:00p.m.
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Q&A

12:00-12:30 p.m.
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Break

12:30-1:45 p.m.
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Session 2: Lung Regeneration and Disease in a Dish

Session Chair: Darrell Kotton, M.D., David C. Seldin Professor in the Department of Medicine and in the Department of Pathology and Laboratory Medicine, Boston University School of Medicine

  • Hans Clevers, M.Sc., M.D., Ph.D., Professor in Molecular Genetics, Utrecht University, Principal Investigator at the Hubrecht Institute, Principal Investigator Princess Máxima Center for Pediatric Oncology, Netherlands
  • Shimpei Gotoh, M.D., Ph.D., Associate Professor of Graduate School of Medicine, Kyoto University, Japan
  • Haiqing Bai, Ph.D., Wyss Technology Development Fellow, Wyss Institute, Harvard University
  • Dan Tschumperlin, Ph.D., Professor in the Department of Physiology and Biomedical Engineering at Mayo Clinic in Rochester, Minnesota
  • Maria Basil, M.D., Ph.D., Pulmonary and Critical Care Fellow at the University of Pennsylvania

1:45-2:30 p.m.
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Q&A

2:30-2:45 p.m.
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Break

2:45-3:30 p.m.
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Special Topic 1: How to Appropriately Define, Benchmark, and Model New Cell Types

  • Xin Sun, Ph.D., Professor of Pediatrics and Biological Sciences at University of California, San Diego
  • Andy Vaughan, Ph.D., Assistant Professor at The University of Pennsylvania School of Veterinary Medicine

3:30-4:15 p.m.
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Special Topic 2: Applications and Challenges with All Models

  • Robert Montgomery, M.D., Chairman and Professor of Surgery at NYU, Langone Health and the Director of the NYU Langone Transplant Institute
  • Purushothama Rao Tata, Ph.D., Assistant Professor, Departments of Cell Biology and Medicine, Duke Regeneration Center, Duke University School of Medicine

4:15-5:00 p.m.
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Special Topic 3: Perspectives from Junior Investigators

  • Kyungtae Lim, Ph.D., Postdoc Researcher in the Gurdon Institute, University of Cambridge, UK
  • Ian Stancil, Ph.D., student at the University of Colorado Anschutz Medical Campus

10:00-11:15 a.m.
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Session 3: Translating Lung Models for Regeneration and Disease

Session Chair: Shahin Rafii, M.D., Arthur B. Belfer Professor of Genetic Medicine, Director of Ansary, Stem Cell Institute and Division Chief of Regenerative Medicine at Weill Cornell Medicine

  • Shahin Rafii, M.D., Arthur B. Belfer Professor of Genetic Medicine, Director of Ansary, Stem Cell Institute and Division Chief of Regenerative Medicine at Weill Cornell Medicine
  • Krishnendu Roy, Ph.D., Robert A. Milton Chaired Professor in Biomedical Engineering, George Tech
  • Mingxia Gu, M.D., Ph.D., Assistant Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center
  • Valerio Dorrello, M.D., Assistant Professor in the Division of Pediatric Critical Care Medicine, Department of Pediatrics, Columbia University Irving Medical Center
  • Hans Snoeck, M.D., Ph.D., Professor of Medicine (in Microbiology & Immunology) at Columbia University Medical Center

11:15 a.m.-12:00 p.m.
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Q&A

12:00-12:30 p.m.
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Break

12:30-1:45 p.m.
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Session 4: Building a Whole Lung and Cell Therapy

Session Chair: Laura Niklason, M.D., Ph.D., President and CEO, Humacyte Inc., Adjunct Professor, Yale University

  • Jinho Kim, M.S., Ph.D., Assistant Professor of the Biomedical Engineering department at Stevens Institute of Technology
  • Richard N. Pierson, III, M.D., Professor of Surgery, Harvard Medical School, Austen Chair in Cardiac Surgery, MGH, Scientific Director, MGH Center for Transplantation Sciences
  • Alexandra Piotrowski-Daspit, Ph.D., Postdoctoral Fellow in the Biomedical Engineering Department at Yale University
  • Adam Feinberg, Ph.D., Principal Investigator of the Regenerative Biomaterials and Therapeutics Group and a Professor at Carnegie Mellon University
  • Jordan Miller, Ph.D., Associate Professor of Bioengineering, Rice University

1:45-2:30 p.m.
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Q&A

2:30-2:45 p.m.
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Break

2:45-3:45 p.m.
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Breakout Group Discussion for Research Priority/Recommendations

3:45-4:45 p.m.
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Breakout Group Reports and Final Summary

4:45-5:00 p.m.
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Workshop Closeout