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HIV-associated Comorbidites, Co-infections, & Complications Workshop event banner

HIV-associated Comorbidites, Co-infections, & Complications Workshop

September 19 - 20, 2019
Natcher Conference Center,
NIH Campus in Bethesda, MD

Description

People with HIV can now have nearly normal lifespans because of significant progress in HIV treatment, but the quality of their lives may be severely impacted by HIV-related comorbidities, co-infections, and complications. The overlapping etiologies and consequences of HIV-associated diseases need to be better understood on a holistic level.

The National Institutes of Health (NIH) Office of AIDS Research (OAR) funds research on HIV-associated comorbidities, co-infections, and complications through multiple Institutes and Centers (ICs), with a focus on diseases that fall within each IC’s mission and HIV/AIDS related funding priorities. This workshop will foster discussion among experts from different fields and disciplines to share their perspectives and explore interrelationships among multiple comorbidities, in an effort to refine research priorities that aim to improve the health and well-being of people with HIV.

Event Details

Workshop Goals

Through presentations, facilitated discussions, and breakout sessions, participants at the workshop will:

  • reach a shared understanding of the current state of the science and emerging HIV-related public health concerns
  • identify research gaps
  • develop a set of recommendations for future multidisciplinary research priorities

More Information

This workshop is free and open to the public on a first-come, first-served basis. If you cannot attend in person, please consider participating by webcast (link will be provided closer to the date of the meeting). Please check back for updated webcast information.

The plenary sessions of the workshop (not breakout sessions) will be videocasted, recorded, and archived. For videocast link please click here.

Individuals with disabilities who need Sign Language Interpreters and reasonable accommodation to participate in this event may contact the NHLBI Office of the Scientific Director (301-496-2116) and/or the Federal Relay (1-800-877-8339). Requests should be made at least five days in advance of the event.

Agenda

9:00 AM - 9:20 AM
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Opening Remarks

Dr. Gary Gibbons and Dr. Timothy Holtz

9:20 AM - 10:30 AM
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Session 1: Introduction

Moderators: Dr. Steven Deeks and Dr. Savita Pahwa

Purpose of the Workshop (10 mins): Dr. Steven Deeks and Dr. Savita Pahwa

Keynote (30 mins): Dr. Anthony Fauci

Current Burden of HIV-associated Comorbidities, Coinfections and Complications (30 mins): Dr. Keri Althoff

10:30 AM - 10:50 AM
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Break

10:50 AM - 11:50 AM
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Session 2: Epidemiologic research

Overview (10 mins)

Priority topics and discussion (45 mins)

Sum-up (5 mins): Dr. Amy Justice and Dr. Ned Sacktor

11:50 AM - 12:45 PM
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Lunch

12:45 PM - 1:45 PM
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Session 3: Pathogenesis research

Overview (10 mins)

Priority topics and discussion (45 mins)

Sum-up (5 mins): Dr. Dana Gabuzda and Dr. Peter Hunt

1:45 PM - 2:45 PM
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Session 4: Clinical research

Overview (10 mins)

Priority topics and discussion (45 mins)

Sum-up (5 mins): Dr. Ann Kurth and Dr. Todd Brown

2:45 PM - 3:00 PM
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Break

3:00 PM - 4:00 PM
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Session 5: Implementation Science research

Overview (10 mins)

Priority topics and discussion (45 mins)

Sum-up (5 mins): Dr. Stefan Baral and Dr. Michael Mugavero

4:00 PM - 5:00 PM
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Session 6: Syndemics

Overview (10 mins)

Priority topics and discussion (45 mins)

Sum-up (5 mins): Dr. Emily Mendenhall and Dr. Ken Mayer

8:45 AM - 9:00 AM
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Recap of Day 1

Dr. Steven Deeks and Dr. Savita Pahwa

9:00 AM - 9:30 AM
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Session 7: Leveraging what has been learned in non-HIV-related comorbidities, aging, and geroscience

Moderator: Dr. Jamie Justice (TBD)

9:30 AM - 10:30 AM
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Session 8: Panel on international research

Moderators: Dr. Roger Detels and Dr. Eugene Mutimura

10:30 AM - 10:45 AM
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Break

10:45 AM - 12:15 PM
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Session 9: Breakout Discussion by WGs

10:45 AM - 12:15 PM
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Epidemiologic and Population Research Breakout Session
Balcony B

Dr. Amy Justice and Dr. Ned Sacktor

This breakout session will examine how observational research in clinical and population settings can address problems of aging with HIV infection (e.g. falls, frailty, mental health conditions, and neurocognitive function). The session will focus on determining what are the most important questions and how best to address them with observational data.

10:45 AM - 12:15 PM
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Pathogenesis/Basic Science Research Breakout Session
Balcony A

Dr. Dana Gabuzda and Dr. Peter Hunt

This breakout session will examine the factors that drive chronic inflammation and immune dysregulation in treated HIV infection, changes in the microbiome and microbiome-host interactions, and how these events influence multiple end-organ diseases. The group will also discuss the biological mechanisms that may drive accentuated aging and impact age-related comorbidities in treated HIV infection.

10:45 AM - 12:15 PM
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Clinical Research Breakout Session
Main Auditorium

Dr. Ann Kurth and Dr. Todd Brown

This breakout session will focus on optimizing clinical research across the lifespan to address screening, prevention, and management of HIV co-morbidities. The group will discuss clinical trial designs that prioritize participant engagement and perspective, surrogate markers, and disparities.

10:45 AM - 12:15 PM
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Implementation Science Research Breakout Session
Balcony C

Dr. Stefan Baral and Dr. Michael Mugavero

This breakout session will focus on prioritizing training and research into optimal strategies for implementing clinical services and public health programs focused on addressing HIV-related comorbidities.

10:45 AM - 12:15 PM
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Syndemics Research Breakout Session
Room A/B

Dr. Emily Mendenhall and Dr. Ken Mayer

This breakout session will examine different aspects of syndemics such as how social, cultural, environmental, political, and economic factors produce vulnerability for HIV and co-conditions, how these factors differ within and between populations, how they may simultaneously affect HIV, non-communicable as well as communicable (co-infection) disease risk, and how syndemics mediated by social/structural factors affects behavioral outcomes. We will also discuss the methodology needed to address syndemic interactions.

12:15 PM - 1:00 PM
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Lunch

1:00 PM - 1:50 PM
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Session 10: Report from WG Breakouts

Moderators: Dr. Steven Deeks and Dr. Savita Pahwa

Epidemiologic research: Dr. Amy Justice and Dr. Ned Sacktor

Pathogenesis research: Dr. Dana Gabuzda and Dr. Peter Hunt

Clinical research: Dr. Ann Kurth and Dr. Todd Brown

IS research: Dr. Stefan Baral and Dr. Michael Mugavero

Syndemics: Dr. Emily Mendenhall and Dr. Ken Mayer

1:50 PM - 2:50 PM
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Session 11: Panel Discussion for Consensus Building

Moderators: Dr. Steven Deeks and Dr. Savita Pahwa

2:50 PM - 3:00 PM
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Closing Remarks

Dr. Steven Deeks and Dr. Savita Pahwa

Register

We recommend registering online in advance by September 16, 2019. However, onsite registration will be available.