60th Annual American Society of Hematology (ASH) Meeting & Exposition

1:05 p.m. Sickle Cell Disease in the Aging Patient – Where Do We Go from Here? Panel Discussion and Questions

Location: Room 33B, San Diego Convention Center

Panelist: Swee Lay Thein, M.B., D.Sc., NHLBI

2:30 p.m. ASH-a-Palooza: BMT Peds and Adult (Blood Buddies/Mentor Session 1)

Location: Section 124, The Porch, Petco Park

Presenter: John Tisdale, M.D., NHLBI

3:25 p.m. NIH Updates Panel: NHLBI Presentation

Location: Ballroom 20A, San Diego Convention Center

Presenter: Pankaj Qasba, Ph.D., NHLBI

3:30 p.m. ASH-a-Palooza: BMT Peds and Adult (Blood Buddies/Mentor Session 2)

Location: Section 124, The Porch, Petco Park

Presenter: John Tisdale, M.D., NHLBI

2:30 p.m. Thrombospondin-1, Platelet Factor 4, and Galectin-1 Are Associated with Engraftment in Patients with Sickle Cell Disease Who Underwent Haploidentical HSCT

Location: Grand Hall B, Manchester Grand Hyatt

Presenter: Ahmad Shaikh, NHLBI

4:00 p.m. Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Location: Grand Hall A, Manchester Grand Hyatt

Presenter: Alana Vicente, M.D., NHLBI

4:45 p.m. Ibrutinib Increases the Clonality of TCR Repertoire in Patients with Chronic Lymphocytic Leukemia

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Maria Joao Baptista, Ph.D., Pharm.D., NHLBI

6:15 p.m. A Phase 2 Study of Carfilzomib, Lenalidomide, and Dexamethasone with Lenalidomide Maintenance (KRd-r) in Newly Diagnosed Multiple Myeloma (NDMM): Sustained Long Term Deep Remissions and Prolonged Progression-Free Duration Regardless of Age or Cytogenetic Risk after 5 Years of Follow up

Location: Hall GH, San Diego Convention Center

Presenter: Dickran Kazandjian, M.D., NIH

6:15 p.m. Development of a Clinically Applicable Method for High-Efficiency Gene Correction of Plerixafor-Mobilized CD34+ Cells from Patients with Sickle Cell Disease

Location: Hall GH, San Diego Convention Center

Presenter: Naoya Uchida, M.D., NHLBI

6:15 p.m. Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Location: Hall GH, San Diego Convention Center

Presenter: Taehoon Shin, Ph.D., NHLBI

6:15 p.m. Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

Location: Hall GH, San Diego Convention Center

Presenter: Laxminath Tumburu, Ph.D., NHLBI

7:30 a.m. Platelet Biogenesis in the Lung Circulation

Location: Room 31B, San Diego Convention Center

Presenter: Mark Looney, M.D., University of California – San Francisco

7:30 a.m. Spatial Structure of Plasma Coagulation Factor XIII and Changes with Activation

Location: Room 33B, San Diego Convention Center

Presenter: Anna Protopopova, Ph.D., University of Pennsylvania

7:45 a.m. A Bhlhe40/GM-CSF Axis Potentiates Gastrointestinal Tract Inflammation during Acute Graft Versus Host Disease

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Clinton Piper, Medical College of Wisconsin

7:45 a.m. Determination of the Structural Changes Accompanying Binding of Protein S to Factor IXa

Location: Room 33B, San Diego Convention Center

Moderator: Sabyasachi Chatterjee, Ph.D., M.Sc., Louisiana State University Health Science Center

7:45 a.m. Impact of Hyperfiltration during Early Childhood on the Natural History of Albuminuria in Pediatric Sickle Cell Anemia

Location: Room 25B, San Diego Convention Center

Moderator: Jeffrey Lebensburger, D.O., M.S.P.H., University of Alabama at Birmingham

8:00 a.m. Clinical, Laboratory, and Genetic Risk Factors for Thrombosis in Sickle Cell Disease

Location: Room 25B, San Diego Convention Center

Presenter: Andrew Srisuwananukorn, M.D., University of Illinois at Chicago

8:00 a.m. The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Location: Room 33B, San Diego Convention Center

Presenter: Paul Spiegel, Ph.D., Western Washington University

8:00 a.m. Oral Nutrition Modulates the Intestinal Barrier Following Cytotoxic Therapy Via the Microbiome

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Zaker Schwabkey, M.D., Albany Medical Center

8:15 a.m. Von Willebrand Factor Binding to Myosin Assists in Coagulation

Location: Room 33B, San Diego Convention Center

Moderator: Veronica Flood, M.D., Medical College of Wisconsin

8:45 a.m. Neutropenia-Associated Mutations Differentially Impact Developmental Cell-States

Location: Grand Hall C, Manchester Grand Hyatt

Moderator: H. Leighton Grimes, Ph.D., Cincinnati Children’s Hospital Medical Center

9:30 a.m. Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Location: Room 25B, San Diego Convention Center

Presenter: Sergei Doulatov, Ph.D., University of Washington School of Medicine

9:30 a.m. Extracellular Vesicle microRNA: A Biomarker for Vascular Dysfunction in Pregnancy?

Location: Room 24B, San Diego Convention Center

Presenter: Louise Laurent, M.D., Ph.D., University of California – San Diego

9:30 a.m. Swinging the Iron Pendulum: Loss and Gain Through Blood Donation and Transfusion

Location: Room 33B, San Diego Convention Center

Presenters: Alan Mast, M.D., Ph.D., BloodCenter of Wisconsin and Eldad Hod, M.D., Columbia University Medical Center

9:30 a.m. Microbiota and Neutrophil Development

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Paul Frenette, M.D., Albert Einstein College of Medicine

9:30 a.m. T Cell Metabolism and Memory

Location: Room 30D, San Diego Convention Center

Presenter: Jeffrey Rathmell, Ph.D., Vanderbilt University Medical Center

9:45 a.m. Invariant Patterns of Clonal Succession Determines Specific Phenotypic and Clinical Features of Myelodysplastic Syndromes (MDS)

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Yasunobu Nagata, Cleveland Clinic Foundation

10:00 a.m. Neutrophil KLF2 Regulates Arterial and Venous Thrombosis

Location: Room 28D, San Diego Convention Center

Presenter: Lalitha Nayak, M.D., University Hospitals Cleveland Medical Center

10:15 a.m. Endothelial O-Glycoproteins Cooperate with Platelet CLEC-2 Signaling to Maintain Cerebrovascular Integrity during Mouse Development

Location: Room 28D, San Diego Convention Center

Presenter: Jianxin Fu, MD, Ph.D., Oklahoma Medical Research Foundation

10:15 a.m. DNA Methylation Identifies Genetically and Prognostically Distinct Subtypes of MDS

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Brian Reilly, University of California - San Diego

10:45 a.m. High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Location: Room 7B, San Diego Convention

Presenter: Linda Resar, M.D., Johns Hopkins University School of Medicine

12:30p.m. Predicting Risk of Venous Thromboembolism in Multiple Myeloma: The Impede VTE Score

Location: Room 29C, San Diego Convention Center

Presenter: Kristen Sanfilippo, M.D., Washington University of St Louis School of Medicine

12:30p.m. Macrophage Factor Xa Signaling Promotes Cancer Immune Evasion

Location: Room 31B, San Diego Convention Center

Presenter: Claudine Graf, M.D., Ph.D., Johannes Gutenberg University Medical Center

1:15 p.m. The Un-BLyS-Ful State: Blocking Factor VIII Inhibitor Development with BLyS Depletion

Location: Room 31B, San Diego Convention Center

Presenter: Bhavya Doshi, M.D., University of Pennsylvania

1:15 p.m. The HAS-RISC Score for Venous Thromboembolism (VTE) Risk Stratification in Newly Diagnosed Multiple Myeloma Patients Starting Immunomodulatory Drugs (IMID)

Location: Room 29C, San Diego Convention Center

Presenter: Ang Li, M.D., University of Washington School of Medicine

2:00 p.m. Vascular Biology Components of Hemostasis

Location: Room 31B, San Diego Convention Center

Presenters: Mukesh Jain, M.D., Case Western Reserve University Hospitals Health System and Rodney Camire, Ph.D., Perelman School of Medicine at the University of Pennsylvania

2:00 p.m. Reprogrammed Adult Human Endothelium into Hematopoietic Stem Cells Yields Functional T Cells In Vivo

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: José Gabriel Barcia Durán, Weill Cornell Medicine

2:45 p.m. HSCs Transition from Fetal to Adult Transcriptional States through Gradual Epigenomic Reprogramming That Begins Shortly after Birth

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Jeffrey Magee, MD, Ph.D., Washington University School of Medicine

4:00 p.m. Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Location: Room 25B, San Diego Convention Center

Presenter: Sergei Doulatov, Ph.D., University of Washington School of Medicine

4:00 p.m. Extracellular Vesicle microRNA: A Biomarker for Vascular Dysfunction in Pregnancy?

Location: Room 11B, San Diego Convention Center

Presenter: Louise Laurent, M.D., Ph.D., University of California – San Diego

4:00 p.m. A Broad Spectrum of Red Blood Cell Disorders Due to KLF1 Variants

Location: Room 33B, San Diego Convention Center

Presenter: James Bieker, Ph.D., Icahn School of Medicine at Mount Sinai

4:00 p.m. Hepatocyte-Derived Tissue Plasminogen Activator Regulates Systemic Fibrinolysis

Location: Room 28D, San Diego Convention Center

Presenter: Ze Zheng, M.D., Ph.D., Columbia University

4:30 p.m. The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

Location: Room 28D, San Diego Convention Center

Presenter: Qizhen Shi, M.D., Medical College of Wisconsin Blood Research Institute

5:00 p.m. A Murine Model of Type 2N VWD Was Developed By CRISPR/Cas9 Gene Editing and Recapitulates Human Type 2N VWD

Location: Room 28D, San Diego Convention Center

Presenter: Robert Montgomery, M.D., BloodCenter of Wisconsin

6:15 p.m. Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial

Location: Hall GH, San Diego Convention Center

Presenter: Julie Kanter, M.D., Medical University of South Carolina

4:30 p.m. Panel on Stem Cell Transplantation for Sickle Cell Disease

Location: Ballroom 20A, San Diego Convention Center

Presenters: John Tisdale, M.D., NHLBI

6:00 p.m. Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Location: Hall GH, San Diego Convention Center

Presenters: Heather Huntsman, Ph.D., NHLBI

7:30 a.m. Vascular Biology Components of Hemostasis

Location: Room 31B, San Diego Convention Center

Presenters: Mukesh Jain, M.D., Case Western Reserve University Hospitals Health System and Rodney Camire, Ph.D., Perelman School of Medicine at the University of Pennsylvania

7:30 a.m. Microbiota and Neutrophil Development

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Paul Frenette, M.D., Albert Einstein College of Medicine

7:30 a.m. Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Amrita Sarkar, Ph.D., Children's Hospital of Philadelphia

7:45 a.m. Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and Vwf

Location: Room 33B, San Diego Convention Center

Presenter: Erica Sparkenbaugh, Ph.D., B.S., UNC Chapel Hill McAllister Heart Institute

8:00 a.m. Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited

Location: Room 33B, San Diego Convention Center

Presenter: Md Nasimuzzaman, Ph.D., Cincinnati Children's Hospital Medical Center

8:15 a.m. Ptpn6 Inhibits IL-1 Release from Neutrophils By Regulation of Caspase-8- and Ripk3/Mlkl-Dependent Forms of Cell Death

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Ben Croker, Ph.D., Boston Children's Hospital

8:15 a.m. High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Location: Room 33B, San Diego Convention Center

Presenter: Erica Sparkenbaugh, Ph.D., B.S., UNC Chapel Hill McAllister Heart Institute

8:30 a.m. Mast Cells Contribute to Brain Microvascular Permeability in Sickle Cell Disease

Location: Room 33B, San Diego Convention Center

Presenter: Aditya Mittal, University of Minnesota

8:45 a.m. Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Ben Croker, Ph.D., Boston Children's Hospital

8:45 a.m. Mn Porphyrin-Based Redox Active Drugs As Novel Anti-Adhesive and Anti-Inflammatory Agents Targeting Sickle Red Blood Cell Oxidative Damage In Vivo

Location: Room 33B, San Diego Convention Center

Presenter: Thamilarasan Madhan, Ph.D., Duke University

9:30 a.m. A Broad Spectrum of Red Blood Cell Disorders Due to KLF1 Variants

Location: Room 24B, San Diego Convention Center

Presenter: James Bieker, Ph.D., Icahn School of Medicine at Mount Sinai

9:30 a.m. Platelet Biogenesis in the Lung Circulation

Location: Room 31B, San Diego Convention Center

Presenter: Mark Looney, M.D., University of California – San Francisco

9:30 a.m. T Cell Metabolism and Memory

Location: Room 30D, San Diego Convention Center

Presenter: Jeffrey Rathmell, Ph.D., Vanderbilt University Medical Center

9:30 a.m. Glycobiology in Hematology: The New Frontier

Location: Room 29C, San Diego Convention Center

Presenters: Karin Hoffmeister, M.D., BloodCenter of Wisconsin, Robert Sackstein, M.D. Brigham and Women’s Hospital, and Sean Stowell, M.D., Ph.D., Emory University

9:30 a.m. The Incidence of Thromboembolism for Lenalidomide Versus Thalidomide in Older Patients with Newly Diagnosed Multiple Myeloma

Location: Room 8, San Diego Convention Center

Presenter: Ang Li, M.D., University of Washington School of Medicine

12:00 p.m. Novel Structural Variants Originating in F8 Non-Coding Regions in Previously Unresolved Cases of Severe Hemophilia A

Location: Ballroom 20D, San Diego Convention Center

Presenter: Marsha Wheeler, Ph.D, University of Washington

12:15 p.m. Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency – Results of the ART Study

Location: Room 29C, San Diego Convention Center

Presenter: J. Evan Sadler, M.D., Ph.D., Washington University in St. Louis

1:00 p.m. The Risk of Major Bleeding in Patients with Suspected Heparin-Induced Thrombocytopenia (HIT)

Location: Room 29C, San Diego Convention Center

Presenter: Allyson Pishko, M.D., Hospital of University of Pennsylvania

2:00 p.m. Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

Location: Hall AB, San Diego Convention Center

Presenter: Leon Tshilolo, M.D., Ph.D., Centre Hospitalier Monkole, The Democratic Republic of the Congo

4:30 p.m. Swinging the Iron Pendulum: Loss and Gain Through Blood Donation and Transfusion

Location: Room 29C, San Diego Convention Center

Presenters: Alan Mast, M.D., Ph.D., BloodCenter of Wisconsin and Eldad Hod, M.D., Columbia University Medical Center

4:30 p.m. Red Blood Transfusion Does Not Increase Risk for Venous or Arterial Thrombosis

Location: Room 30D, San Diego Convention Center

Presenters: Lisa Baumann Kreuziger, M.D., M.S., BloodCenter of Wisconsin

4:30 p.m. An Evaluation of Promis Health Domains in Adults with Hemophilia: A Cross-Sectional Study

Location: Room 24B, San Diego Convention Center

Presenters: Vaughn Barry, Ph.D., M.P.H., Emory University School of Medicine

4:45 p.m. Peroxisome Proliferator Activated Receptor-Delta Controls Fat Oxidation in Alloreactive T Cells

Location: Grand Hall D, Manchester Grand Hyatt

Presenters: Craig Byersdorfer, M.D., University of Pittsburgh

5:00 p.m. GO-8: Preliminary Results of a Phase I/II Dose Escalation Trial of Gene Therapy for Haemophilia a Using a Novel Human Factor VIII Variant

Location: Room 6B, San Diego Convention Center

Presenters: Pratima Chowdary, M.D., Royal Free Hospital of London

5:00 p.m. Risk of Venous Thrombosis in Patients with Sickle Cell Trait after Orthopedic Surgery

Location: Room 30D, San Diego Convention Center

Presenters: Petra Martin, University Hospitals Cleveland Medical Center

5:15 p.m. Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation

Location: Room 25B, San Diego Convention Center

Presenters: Anindita Basak, Ph.D., Harvard Medical School

5:15 p.m. Surprisingly Rapid Onset of Estrogen-Induced Venous Thrombosis in an Animal Model

Location: Room 30D, San Diego Convention Center

Presenters: Xinge Yu, Ph.D., University of Michigan Medical School,

5:30 p.m. Adeno-Associated Mediated Gene Transfer for Hemophilia B:8 Year Follow up and Impact of Removing "Empty Viral Particles" on Safety and Efficacy of Gene Transfer

Location: Room 6B, San Diego Convention Center

Presenters: Ulrike Reiss, M.D., St. Jude Children's Research Hospital

5:45 p.m. Vasoactive Intestinal Peptide Synthesis in Transplant Recipients Critically Regulate Donor T Cell Alloreactivity and Graft-Versus-Host Disease

Location: Grand Hall D, Manchester Grand Hyatt

Presenters: Yiwen Li, M.M.Sc., Emory University

6:00 p.m. Inpatient Mortality and Length of Stay Among Direct-Acting Oral Anticoagulant (DOAC) and Warfarin Users Presenting with Major Hemorrhage

Location: Hall GH, San Diego Convention Center

Presenter: Walter Bialkowski, Ph.D., BloodCenter of Wisconsin

7:45 a.m. Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Location: Grand Ballroom 2, Marriott Marquis

Moderator: Xing Fan, M.D., NHLBI

8:00 a.m. Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Location: Grand Ballroom 2, Marriott Marquis

Presenter: Fernanda Gutierrez-Rodrigues, Ph.D., NHLBI

11:45 a.m. Validation of Clinical Prognostic Models and Integration of Genetic Biomarkers of Drug Resistance in CLL Patients Treated with Ibrutinib

Location: Ballroom 20A, San Diego Convention Center

Presenter: Inhye Ahn, M.D., NHLBI

12:15 p.m. Featured Topic: Sickle Cell Disease: New Drugs, Curative Approaches

Location: Room 28D, San Diego Convention Center

Moderator: Matthew Hsieh, M.D., NHLBI

1:30 p.m. Ernest Beutler Lecture and Prize: Clinical/Translational Lecture

Location: Hall AB, San Diego Convention Center

Lecturer and Award Recipient: Neal Young, M.D., NHLBI

6:00 p.m. Generation of Fanconi Anemia iPSC Clones By Addition of a Small Molecule Inhibitor of p53 during Reprogramming

Location: Hall GH, San Diego Convention Center

Presenter: Husam Qanash, M.Sc., NHLBI

7:30 p.m. Current Results of Lentiglobin Gene Therapy in Patients with Severe Sickle Cell Disease Treated Under a Refined Protocol in the Phase 1 Hgb-206 Study

Location: Room 6B, San Diego Convention Center

Presenter: John Tisdale, M.D., NHLBI

7:00 a.m. Active and Ultra-Large Von Willebrand Factor Is Significantly Elevated in Patients with Immune Thrombotic Thrombocytopenic Purpura

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Wenjing Cao, Ph.D., The University of Alabama at Birmingham

7:15 a.m. Prostaglandin E2 Stimulates CREB-Mediated Modification of Histone Variant Nucleosomes at Enhancers to Promote Hematopoietic Stem Cell Fate

Location: Pacific Ballroom 24, Marriott Marquis

Presenter: Audrey Sporrij, M.Sc., Harvard University

7:30 a.m. Clinical and Laboratory Benefits of Early Initiation of Hydroxyurea with Pharmacokinetic Guided Dosing for Young Children with Sickle Cell Anemia

Location: Room 28D, San Diego Convention Center

Presenter: Patrick McGann, M.D., Cincinnati Children's Hospital Medical Center

7:30 a.m. RAB31-Mediated Endosomal Trafficking Is Defective in RUNX1 Haplodeficiency

Location: Room 31B, San Diego Convention Center

Presenter: Gauthami Jalagadugula, Ph.D., Lewis Katz School of Medicine at Temple University

7:45 a.m. Identification of the Genetic Variant Responsible for Variable Platelet CD36 Expression By Massively Parallel Reporter Assay

Location: Room 31B, San Diego Convention Center

Presenter: Leonard Edelstein, Ph.D., Thomas Jefferson University

7:45 a.m. Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes
Location: Room 28D, San Diego Convention Center
Moderator: Claudia Morris, M.D., Emory University School of Medicine

8:00 a.m. Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Location: Room 31B, San Diego Convention Center

Presenter: Oleg Kim, Ph.D., University of Pennsylvania Perelman School of Medicine

8:00 a.m. Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited Anemia

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Kimberly Lezon-Geyda, Ph.D., Yale University School of Medicine

8:15 a.m. Polyclonal Immune Response in T-LGL Leads to Clonal Expansions Preceding Occurrence of STAT3 Mutations Further Solidifying Clonal Dominance

Location: Room 8, San Diego Convention Center

Presenter: Cassandra Hirsch, Cleveland Clinic Foundation

10:45 a.m. Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein

Location: Grand Ballroom 2, Marriott Marquis

Presenter: Raffaele Renella, M.D., Ph.D., University Hospital of Lausanne

11:45 a.m. Area-Based Socioeconomic Status and Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Outcomes: A CIBMTR Analysis

Location: Room 24B, San Diego Convention Center

Presenter: Kira Bona, M.D., M.P.H., Children's Hospital Boston

2:45 p.m. Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice

Location: Room 11B, San Diego Convention Center

Presenter: Philipp Rauch, M.D., Boston University School of Medicine

2:45 p.m. Multicenter Microbiota Analysis Indicates That Pre-HCT Microbiota Injury Is Prevalent across Geography and Predicts Poor Overall Survival

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Jonathan Peled, M.D., Ph.D., Memorial Sloan Kettering Cancer Center

2:45 p.m. Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Victor Tkachev, Ph.D., Seattle Children's Research Institute

3:00 p.m. Generation of iPSC-Derived Human Megakaryocytes for Flow Cytometric Detection of Platelet-Specific Alloantibodies

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Nanyan Zhang, M.D., Ph.D., BloodCenter of Wisconsin

3:00 p.m. Very Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy for Prevention of Viral Infection after Allogeneic T Cell Depleted Stem Cell Transplantation

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Pawel Muranski, M.D., Columbia University Medical Center

3:00 p.m. Early Clonal Hematopoiesis Detected in Gata2 heterozygosity By Color-Barcoding of Hematopoietic Stem Cells in Zebrafish

Location: Room 11B, San Diego Convention Center

Presenter: Serine Avagyan, M.D., Ph.D., Dana-Farber Cancer Institute - Boston Children's Hospital

3:15 p.m. Short-Acting Anti-VWF Aptamer Improves the Recovery and Survival, and Hemostatic Functions of Refrigerated Platelets

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Wenchun Chen, Ph.D., Emory University School of Medicine

3:30 p.m. Health Care Reimbursement and Service Utilization Among Medicare Beneficiaries with Multiple Myeloma Receiving Autologous Hematopoietic Cell Transplantation in Inpatient and Outpatient Settings

Location: Room 24B, San Diego Convention Center

Presenter: Neil Dunavin, M.D., University of Kansas Medical Center

3:30 p.m. Targeting Elastase with Alpha1 Anti-Trypsin Reduces Hyperalgesia in Mice with Sickle Cell Disease

Location: Room 29C, San Diego Convention Center

Presenter: Aithanh Nguyen, University of Minnesota

3:30 p.m. The Association between Transplant-Associated Thrombotic Microangiopathy and Calcineurin Inhibitor and Sirolimus Levels

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Ang Li, M.D., University of Washington School of Medicine

3:45 p.m. Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: David Gibb, M.D., Ph.D., Cedars-Sinai Medical Center

3:45 p.m. Gvhd Is Sustained By T Cell Maintenance within Target Tissues: Insights from Clonal Tracking and Parabiosis

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Faruk Sacirbegovic Ph.D., University of Pittsburgh

4:00 p.m. Patrolling Monocytes Scavenge Endothelial Adherent Sickle Red Blood Cells in Sickle Cell Disease

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Karina Yazdanbakhsh, Ph.D., New York Blood Center

4:00 p.m. Effect of Chronic Opioid Therapy on Pain and Survival in a Mouse Model of Sickle Cell Disease

Location: Room 29C, San Diego Convention Center

Presenter: Varun Sagi, University of Minnesota

4:30 p.m. Targeting Sec23b in COPII Vesicles Regulates T Cell Immunity

Location: Room 8, San Diego Convention Center

Presenter: Stephanie Kim, B.S., University of Michigan Medical School

4:30 p.m. Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Location: Room 31B, San Diego Convention Center

Presenter: Moua Yang, Ph.D., Department of Biochemistry, Milwaukee

4:45 p.m. The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Katie Giger Seu, Ph.D., Cincinnati Children's Hospital Medical Center

4:45 p.m. Sickle Cell Subjects Have a Stronger and Faster Neurally Mediated Vasoconstriction Response to Cold Pain That Correlates with Anxiety Scores

Location: Room 25B, San Diego Convention Center

Presenter: Saranya Veluswamy, M.D., Children's Hospital Los Angeles

4:45 p.m. Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Location: Grand Hall A, Manchester Grand Hyatt

Presenter: Youmna Kfoury, Ph.D., Massachusetts General Hospital

4:45 p.m. Disruption of Tet2 Dioxygenase Enhances Antitumor Efficiency in CD8+ Tumor Infiltrating Lymphocytes

Location: Room 8, San Diego Convention Center

Presenter: Minjung Lee, M.S., Texas A&M University, Institute of Biosciences and Technology

5:00 p.m. Mitochondrial Regulation Is Essential for Erythroid Nuclear Clearance

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Raymond Liang, Ph.D., Icahn School of Medicine at Mount Sinai

5:00 p.m. Alpha-Granules in Resting Human Platelets Are a Spatially Clustered, Single Major Population

Location: Room 31B, San Diego Convention Center

Presenter: Brian Storrie, Ph.D., University of Arkansas for Medical Sciences

5:15 p.m. A Novel Role for Bst2 and E-Selectin in IFNg-Stimulated HSC Niche Relocalization

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Katie Matatall, Ph.D., Baylor College of Medicine

5:15 p.m. Manipulating Metabolic Plasticity By Targeting Pyruvate Kinase M2 in Platelets Inhibits Arterial Thrombosis

Location: Room 31B, San Diego Convention Center

Presenter: Manasa Nayak, Ph.D., University of Iowa

5:15 p.m. Bmi-1 Regulates Ex Vivo Self-Renewal of Human Erythroblasts

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Jayme Olsen, M.S., University of Rochester

5:30 p.m. Characteristics and Potential Biomarkers of Adult Sickle Cell Patients with Chronic Pain

Location: Room 25B, San Diego Convention Center

Presenter: Camila Albo, Augusta University

6:00 p.m. Long-Term Stability of the Adult Sickle Cell Quality of Life Measure (ASCQ-Me)​

Location: Hall GH, San Diego Convention Center

Presenters: Keesha Roach, Ph.D., R.N., University of Florida,

6:15 p.m. Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study)

Location: Room 29C, San Diego Convention Center

Presenters: Jeffrey Zwicker, M.D., Beth Israel Deaconess Medical Center Harvard Medical School

6:15 p.m. T-Replete Haploidentical Cell Transplantation Using Post-Transplant Cyclophosphamide for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome: Effect of Transplant Conditioning Regimen Intensity on Outcomes

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenters: Scott Solomon, M.D., BMT Group of Georgia

6:15 p.m. Gene Therapy for Sickle Cell Anemia Using a Modified Gamma Globin Lentivirus Vector and Reduced Intensity Conditioning Transplant Shows Promising Correction of the Disease Phenotype

Location: Room 6B, San Diego Convention Center

Presenters: Punam Malik, M.D., Cincinnati Children's Hospital

6:15 p.m. Prospective Diagnosis of VWD in a Large Cohort of Patients with Bleeding Symptoms through the Zimmerman Program

Location: Room 28D, San Diego Convention Center

Presenters: Veronica Flood, M.D., Medical College of Wisconsin

6:30 p.m. A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice 

Location: Room 29C, San Diego Convention Center

Presenters: Randolph Lyde, Ph.D., Perelman School of Medicine of the University of Pennsylvania

7:00 p.m. Single Cell RNA Sequencing of Blood Outgrowth Endothelial Cells from Patients with Low Von Willebrand Factor Reveal Multiple Novel Signaling Pathways

Location: Room 28D, San Diego Convention Center

Presenters: Christopher Ng, M.D., University of Colorado - Children's Hospital Colorado

7:15 p.m. Epigenetic Profiles of Primary Endothelial Cells from Patients with Low VWF Levels

Location: Room 28D, San Diego Convention Center

Presenters: Christopher Ng, M.D., University of Colorado - Children's Hospital Colorado