NEWS & EVENTS
Illustration of blood cells in red background
60th Annual American Society of Hematology (ASH) Meeting & Exposition
December 1 to November 4, 2018
San Diego Convention Center, San Diego, CA
Description

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is participating in the 60th Annual American Society of Hematology (ASH) Meeting & Exposition. NHLBI-supported research will be presented at more than 100 sessions. See the schedule below for a snapshot of the NHLBI’s sessions at #ASH18. NOTE: Times subject to change. Please consult the official ASH schedule.

Featured Session:

9:45 a.m. Presidential Symposium: Accelerating Cures in the Genomic Age

Location: Hall AB, San Diego Convention Center

Presenters: Francis Collins, M.D., Ph.D., NIH

Agenda

1:05 p.m.
-
NIH/NHLBI Presentations

1:05 p.m. Sickle Cell Disease in the Aging Patient – Where Do We Go from Here? Panel Discussion and Questions

Location: Room 33B, San Diego Convention Center

Panelist: Swee Lay Thein, M.B., D.Sc., NHLBI

 

2:30 p.m. ASH-a-Palooza: BMT Peds and Adult (Blood Buddies/Mentor Session 1)

Location: Section 124, The Porch, Petco Park

Presenter: John Tisdale, M.D., NHLBI

 

3:25 p.m. NIH Updates Panel: NHLBI Presentation

Location: Ballroom 20A, San Diego Convention Center

Presenter: Pankaj Qasba, Ph.D., NHLBI

 

3:30 p.m. ASH-a-Palooza: BMT Peds and Adult (Blood Buddies/Mentor Session 2)

Location: Section 124, The Porch, Petco Park

Presenter: John Tisdale, M.D., NHLBI

2:30 p.m.
-
NIH/NHLBI Presentations

2:30 p.m. Thrombospondin-1, Platelet Factor 4, and Galectin-1 Are Associated with Engraftment in Patients with Sickle Cell Disease Who Underwent Haploidentical HSCT

Location: Grand Hall B, Manchester Grand Hyatt

Presenter: Ahmad Shaikh, NHLBI

 

4:00 p.m. Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Location: Grand Hall A, Manchester Grand Hyatt

Presenter: Alana Vicente, M.D., NHLBI

 

4:45 p.m. Ibrutinib Increases the Clonality of TCR Repertoire in Patients with Chronic Lymphocytic Leukemia

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Maria Joao Baptista, Ph.D., Pharm.D., NHLBI

 

6:15 p.m. A Phase 2 Study of Carfilzomib, Lenalidomide, and Dexamethasone with Lenalidomide Maintenance (KRd-r) in Newly Diagnosed Multiple Myeloma (NDMM): Sustained Long Term Deep Remissions and Prolonged Progression-Free Duration Regardless of Age or Cytogenetic Risk after 5 Years of Follow up

Location: Hall GH, San Diego Convention Center

Presenter: Dickran Kazandjian, M.D., NIH

 

6:15 p.m. Development of a Clinically Applicable Method for High-Efficiency Gene Correction of Plerixafor-Mobilized CD34+ Cells from Patients with Sickle Cell Disease

Location: Hall GH, San Diego Convention Center

Presenter: Naoya Uchida, M.D., NHLBI

 

6:15 p.m. Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Location: Hall GH, San Diego Convention Center

Presenter: Taehoon Shin, Ph.D., NHLBI

 

6:15 p.m. Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

Location: Hall GH, San Diego Convention Center

Presenter: Laxminath Tumburu, Ph.D., NHLBI

7:30 a.m.
-
NHLBI-Funded Research

7:30 a.m. Platelet Biogenesis in the Lung Circulation

Location: Room 31B, San Diego Convention Center

Presenter: Mark Looney, M.D., University of California – San Francisco

 

7:30 a.m. Spatial Structure of Plasma Coagulation Factor XIII and Changes with Activation

Location: Room 33B, San Diego Convention Center

Presenter: Anna Protopopova, Ph.D., University of Pennsylvania

 

7:45 a.m. A Bhlhe40/GM-CSF Axis Potentiates Gastrointestinal Tract Inflammation during Acute Graft Versus Host Disease

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Clinton Piper, Medical College of Wisconsin

 

7:45 a.m. Determination of the Structural Changes Accompanying Binding of Protein S to Factor IXa

Location: Room 33B, San Diego Convention Center

Moderator: Sabyasachi Chatterjee, Ph.D., M.Sc., Louisiana State University Health Science Center

 

7:45 a.m. Impact of Hyperfiltration during Early Childhood on the Natural History of Albuminuria in Pediatric Sickle Cell Anemia

Location: Room 25B, San Diego Convention Center

Moderator: Jeffrey Lebensburger, D.O., M.S.P.H., University of Alabama at Birmingham

 

8:00 a.m. Clinical, Laboratory, and Genetic Risk Factors for Thrombosis in Sickle Cell Disease

Location: Room 25B, San Diego Convention Center

Presenter: Andrew Srisuwananukorn, M.D., University of Illinois at Chicago

 

8:00 a.m. The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Location: Room 33B, San Diego Convention Center

Presenter: Paul Spiegel, Ph.D., Western Washington University

 

8:00 a.m. Oral Nutrition Modulates the Intestinal Barrier Following Cytotoxic Therapy Via the Microbiome

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Zaker Schwabkey, M.D., Albany Medical Center

 

8:15 a.m. Von Willebrand Factor Binding to Myosin Assists in Coagulation

Location: Room 33B, San Diego Convention Center

Moderator: Veronica Flood, M.D., Medical College of Wisconsin

 

8:45 a.m. Neutropenia-Associated Mutations Differentially Impact Developmental Cell-States

Location: Grand Hall C, Manchester Grand Hyatt

Moderator: H. Leighton Grimes, Ph.D., Cincinnati Children’s Hospital Medical Center

 

9:30 a.m. Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Location: Room 25B, San Diego Convention Center

Presenter: Sergei Doulatov, Ph.D., University of Washington School of Medicine

 

9:30 a.m. Extracellular Vesicle microRNA: A Biomarker for Vascular Dysfunction in Pregnancy?

Location: Room 24B, San Diego Convention Center

Presenter: Louise Laurent, M.D., Ph.D., University of California – San Diego

 

9:30 a.m. Swinging the Iron Pendulum: Loss and Gain Through Blood Donation and Transfusion

Location: Room 33B, San Diego Convention Center

Presenters: Alan Mast, M.D., Ph.D., BloodCenter of Wisconsin and Eldad Hod, M.D., Columbia University Medical Center

 

9:30 a.m. Microbiota and Neutrophil Development

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Paul Frenette, M.D., Albert Einstein College of Medicine

 

9:30 a.m. T Cell Metabolism and Memory

Location: Room 30D, San Diego Convention Center

Presenter: Jeffrey Rathmell, Ph.D., Vanderbilt University Medical Center

 

9:45 a.m. Invariant Patterns of Clonal Succession Determines Specific Phenotypic and Clinical Features of Myelodysplastic Syndromes (MDS)

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Yasunobu Nagata, Cleveland Clinic Foundation

 

10:00 a.m. Neutrophil KLF2 Regulates Arterial and Venous Thrombosis

Location: Room 28D, San Diego Convention Center

Presenter: Lalitha Nayak, M.D., University Hospitals Cleveland Medical Center

 

10:15 a.m. Endothelial O-Glycoproteins Cooperate with Platelet CLEC-2 Signaling to Maintain Cerebrovascular Integrity during Mouse Development

Location: Room 28D, San Diego Convention Center

Presenter: Jianxin Fu, MD, Ph.D., Oklahoma Medical Research Foundation

 

10:15 a.m. DNA Methylation Identifies Genetically and Prognostically Distinct Subtypes of MDS

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Brian Reilly, University of California - San Diego

 

10:45 a.m. High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Location: Room 7B, San Diego Convention

Presenter: Linda Resar, M.D., Johns Hopkins University School of Medicine

 

12:30p.m. Predicting Risk of Venous Thromboembolism in Multiple Myeloma: The Impede VTE Score

Location: Room 29C, San Diego Convention Center

Presenter: Kristen Sanfilippo, M.D., Washington University of St Louis School of Medicine

 

12:30p.m. Macrophage Factor Xa Signaling Promotes Cancer Immune Evasion

Location: Room 31B, San Diego Convention Center

Presenter: Claudine Graf, M.D., Ph.D., Johannes Gutenberg University Medical Center

 

1:15 p.m. The Un-BLyS-Ful State: Blocking Factor VIII Inhibitor Development with BLyS Depletion

Location: Room 31B, San Diego Convention Center

Presenter: Bhavya Doshi, M.D., University of Pennsylvania

 

1:15 p.m. The HAS-RISC Score for Venous Thromboembolism (VTE) Risk Stratification in Newly Diagnosed Multiple Myeloma Patients Starting Immunomodulatory Drugs (IMID)

Location: Room 29C, San Diego Convention Center

Presenter: Ang Li, M.D., University of Washington School of Medicine

 

2:00 p.m. Vascular Biology Components of Hemostasis

Location: Room 31B, San Diego Convention Center

Presenters: Mukesh Jain, M.D., Case Western Reserve University Hospitals Health System and Rodney Camire, Ph.D., Perelman School of Medicine at the University of Pennsylvania

 

2:00 p.m. Reprogrammed Adult Human Endothelium into Hematopoietic Stem Cells Yields Functional T Cells In Vivo

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: José Gabriel Barcia Durán, Weill Cornell Medicine

 

2:45 p.m. HSCs Transition from Fetal to Adult Transcriptional States through Gradual Epigenomic Reprogramming That Begins Shortly after Birth

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Jeffrey Magee, MD, Ph.D., Washington University School of Medicine

 

4:00 p.m. Targeting Autophagy as a Therapeutic Pathway in Diamond-Blackfan Anemia

Location: Room 25B, San Diego Convention Center

Presenter: Sergei Doulatov, Ph.D., University of Washington School of Medicine

 

4:00 p.m. Extracellular Vesicle microRNA: A Biomarker for Vascular Dysfunction in Pregnancy?

Location: Room 11B, San Diego Convention Center

Presenter: Louise Laurent, M.D., Ph.D., University of California – San Diego

 

4:00 p.m. A Broad Spectrum of Red Blood Cell Disorders Due to KLF1 Variants

Location: Room 33B, San Diego Convention Center

Presenter: James Bieker, Ph.D., Icahn School of Medicine at Mount Sinai

 

4:00 p.m. Hepatocyte-Derived Tissue Plasminogen Activator Regulates Systemic Fibrinolysis

Location: Room 28D, San Diego Convention Center

Presenter: Ze Zheng, M.D., Ph.D., Columbia University

 

4:30 p.m. The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

Location: Room 28D, San Diego Convention Center

Presenter: Qizhen Shi, M.D., Medical College of Wisconsin Blood Research Institute

 

5:00 p.m. A Murine Model of Type 2N VWD Was Developed By CRISPR/Cas9 Gene Editing and Recapitulates Human Type 2N VWD

Location: Room 28D, San Diego Convention Center

Presenter: Robert Montgomery, M.D., BloodCenter of Wisconsin

 

6:15 p.m. Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial

Location: Hall GH, San Diego Convention Center

Presenter: Julie Kanter, M.D., Medical University of South Carolina

4:30 p.m.
-
NIH/NHLBI Presentations

4:30 p.m. Panel on Stem Cell Transplantation for Sickle Cell Disease

Location: Ballroom 20A, San Diego Convention Center

Presenters: John Tisdale, M.D., NHLBI

6:00 p.m. Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Location: Hall GH, San Diego Convention Center

Presenters: Heather Huntsman, Ph.D., NHLBI

7:30 a.m.
-
NHLBI-Funded Research

7:30 a.m. Vascular Biology Components of Hemostasis

Location: Room 31B, San Diego Convention Center

Presenters: Mukesh Jain, M.D., Case Western Reserve University Hospitals Health System and Rodney Camire, Ph.D., Perelman School of Medicine at the University of Pennsylvania

 

7:30 a.m. Microbiota and Neutrophil Development

Location: San Diego Ballroom B, Marriott Marquis

Presenter: Paul Frenette, M.D., Albert Einstein College of Medicine

 

7:30 a.m. Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Amrita Sarkar, Ph.D., Children's Hospital of Philadelphia

 

7:45 a.m. Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and Vwf

Location: Room 33B, San Diego Convention Center

Presenter: Erica Sparkenbaugh, Ph.D., B.S., UNC Chapel Hill McAllister Heart Institute

 

8:00 a.m. Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited

Location: Room 33B, San Diego Convention Center

Presenter: Md Nasimuzzaman, Ph.D., Cincinnati Children's Hospital Medical Center

 

8:15 a.m. Ptpn6 Inhibits IL-1 Release from Neutrophils By Regulation of Caspase-8- and Ripk3/Mlkl-Dependent Forms of Cell Death

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Ben Croker, Ph.D., Boston Children's Hospital

 

8:15 a.m. High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Location: Room 33B, San Diego Convention Center

Presenter: Erica Sparkenbaugh, Ph.D., B.S., UNC Chapel Hill McAllister Heart Institute

 

8:30 a.m. Mast Cells Contribute to Brain Microvascular Permeability in Sickle Cell Disease

Location: Room 33B, San Diego Convention Center

Presenter: Aditya Mittal, University of Minnesota

 

8:45 a.m. Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Ben Croker, Ph.D., Boston Children's Hospital

 

8:45 a.m. Mn Porphyrin-Based Redox Active Drugs As Novel Anti-Adhesive and Anti-Inflammatory Agents Targeting Sickle Red Blood Cell Oxidative Damage In Vivo

Location: Room 33B, San Diego Convention Center

Presenter: Thamilarasan Madhan, Ph.D., Duke University

 

9:30 a.m. A Broad Spectrum of Red Blood Cell Disorders Due to KLF1 Variants

Location: Room 24B, San Diego Convention Center

Presenter: James Bieker, Ph.D., Icahn School of Medicine at Mount Sinai

 

9:30 a.m. Platelet Biogenesis in the Lung Circulation

Location: Room 31B, San Diego Convention Center

Presenter: Mark Looney, M.D., University of California – San Francisco

 

9:30 a.m. T Cell Metabolism and Memory

Location: Room 30D, San Diego Convention Center

Presenter: Jeffrey Rathmell, Ph.D., Vanderbilt University Medical Center

 

9:30 a.m. Glycobiology in Hematology: The New Frontier

Location: Room 29C, San Diego Convention Center

Presenters: Karin Hoffmeister, M.D., BloodCenter of Wisconsin, Robert Sackstein, M.D. Brigham and Women’s Hospital, and Sean Stowell, M.D., Ph.D., Emory University

 

9:30 a.m. The Incidence of Thromboembolism for Lenalidomide Versus Thalidomide in Older Patients with Newly Diagnosed Multiple Myeloma

Location: Room 8, San Diego Convention Center

Presenter: Ang Li, M.D., University of Washington School of Medicine

 

12:00 p.m. Novel Structural Variants Originating in F8 Non-Coding Regions in Previously Unresolved Cases of Severe Hemophilia A

Location: Ballroom 20D, San Diego Convention Center

Presenter: Marsha Wheeler, Ph.D, University of Washington

 

12:15 p.m. Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency – Results of the ART Study

Location: Room 29C, San Diego Convention Center

Presenter: J. Evan Sadler, M.D., Ph.D., Washington University in St. Louis

 

1:00 p.m. The Risk of Major Bleeding in Patients with Suspected Heparin-Induced Thrombocytopenia (HIT)

Location: Room 29C, San Diego Convention Center

Presenter: Allyson Pishko, M.D., Hospital of University of Pennsylvania

 

2:00 p.m. Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

Location: Hall AB, San Diego Convention Center

Presenter: Leon Tshilolo, M.D., Ph.D., Centre Hospitalier Monkole, The Democratic Republic of the Congo

 

4:30 p.m. Swinging the Iron Pendulum: Loss and Gain Through Blood Donation and Transfusion

Location: Room 29C, San Diego Convention Center

Presenters: Alan Mast, M.D., Ph.D., BloodCenter of Wisconsin and Eldad Hod, M.D., Columbia University Medical Center

 

4:30 p.m. Red Blood Transfusion Does Not Increase Risk for Venous or Arterial Thrombosis

Location: Room 30D, San Diego Convention Center

Presenters: Lisa Baumann Kreuziger, M.D., M.S., BloodCenter of Wisconsin

 

4:30 p.m. An Evaluation of Promis Health Domains in Adults with Hemophilia: A Cross-Sectional Study

Location: Room 24B, San Diego Convention Center

Presenters: Vaughn Barry, Ph.D., M.P.H., Emory University School of Medicine

 

4:45 p.m. Peroxisome Proliferator Activated Receptor-Delta Controls Fat Oxidation in Alloreactive T Cells

Location: Grand Hall D, Manchester Grand Hyatt

Presenters: Craig Byersdorfer, M.D., University of Pittsburgh

 

5:00 p.m. GO-8: Preliminary Results of a Phase I/II Dose Escalation Trial of Gene Therapy for Haemophilia a Using a Novel Human Factor VIII Variant

Location: Room 6B, San Diego Convention Center

Presenters: Pratima Chowdary, M.D., Royal Free Hospital of London

 

5:00 p.m. Risk of Venous Thrombosis in Patients with Sickle Cell Trait after Orthopedic Surgery

Location: Room 30D, San Diego Convention Center

Presenters: Petra Martin, University Hospitals Cleveland Medical Center

 

5:15 p.m. Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation

Location: Room 25B, San Diego Convention Center

Presenters: Anindita Basak, Ph.D., Harvard Medical School

 

5:15 p.m. Surprisingly Rapid Onset of Estrogen-Induced Venous Thrombosis in an Animal Model

Location: Room 30D, San Diego Convention Center

Presenters: Xinge Yu, Ph.D., University of Michigan Medical School,

 

5:30 p.m. Adeno-Associated Mediated Gene Transfer for Hemophilia B:8 Year Follow up and Impact of Removing "Empty Viral Particles" on Safety and Efficacy of Gene Transfer

Location: Room 6B, San Diego Convention Center

Presenters: Ulrike Reiss, M.D., St. Jude Children's Research Hospital

 

5:45 p.m. Vasoactive Intestinal Peptide Synthesis in Transplant Recipients Critically Regulate Donor T Cell Alloreactivity and Graft-Versus-Host Disease

Location: Grand Hall D, Manchester Grand Hyatt

Presenters: Yiwen Li, M.M.Sc., Emory University

 

6:00 p.m. Inpatient Mortality and Length of Stay Among Direct-Acting Oral Anticoagulant (DOAC) and Warfarin Users Presenting with Major Hemorrhage

Location: Hall GH, San Diego Convention Center

Presenter: Walter Bialkowski, Ph.D., BloodCenter of Wisconsin

7:45 a.m.
-
NIH/NHLBI Presentations

7:45 a.m. Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Location: Grand Ballroom 2, Marriott Marquis

Moderator: Xing Fan, M.D., NHLBI

 

8:00 a.m. Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Location: Grand Ballroom 2, Marriott Marquis

Presenter: Fernanda Gutierrez-Rodrigues, Ph.D., NHLBI

 

11:45 a.m. Validation of Clinical Prognostic Models and Integration of Genetic Biomarkers of Drug Resistance in CLL Patients Treated with Ibrutinib

Location: Ballroom 20A, San Diego Convention Center

Presenter: Inhye Ahn, M.D., NHLBI

 

12:15 p.m. Featured Topic: Sickle Cell Disease: New Drugs, Curative Approaches

Location: Room 28D, San Diego Convention Center

Moderator: Matthew Hsieh, M.D., NHLBI

 

1:30 p.m. Ernest Beutler Lecture and Prize: Clinical/Translational Lecture

Location: Hall AB, San Diego Convention Center

Lecturer and Award Recipient: Neal Young, M.D., NHLBI

 

6:00 p.m. Generation of Fanconi Anemia iPSC Clones By Addition of a Small Molecule Inhibitor of p53 during Reprogramming

Location: Hall GH, San Diego Convention Center

Presenter: Husam Qanash, M.Sc., NHLBI

 

7:30 p.m. Current Results of Lentiglobin Gene Therapy in Patients with Severe Sickle Cell Disease Treated Under a Refined Protocol in the Phase 1 Hgb-206 Study

Location: Room 6B, San Diego Convention Center

Presenter: John Tisdale, M.D., NHLBI

7:00 a.m.
-
NHLBI-Funded Research

7:00 a.m. Active and Ultra-Large Von Willebrand Factor Is Significantly Elevated in Patients with Immune Thrombotic Thrombocytopenic Purpura

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Wenjing Cao, Ph.D., The University of Alabama at Birmingham

 

7:15 a.m. Prostaglandin E2 Stimulates CREB-Mediated Modification of Histone Variant Nucleosomes at Enhancers to Promote Hematopoietic Stem Cell Fate

Location: Pacific Ballroom 24, Marriott Marquis

Presenter: Audrey Sporrij, M.Sc., Harvard University

 

7:30 a.m. Clinical and Laboratory Benefits of Early Initiation of Hydroxyurea with Pharmacokinetic Guided Dosing for Young Children with Sickle Cell Anemia

Location: Room 28D, San Diego Convention Center

Presenter: Patrick McGann, M.D., Cincinnati Children's Hospital Medical Center

 

7:30 a.m. RAB31-Mediated Endosomal Trafficking Is Defective in RUNX1 Haplodeficiency

Location: Room 31B, San Diego Convention Center

Presenter: Gauthami Jalagadugula, Ph.D., Lewis Katz School of Medicine at Temple University

 

7:45 a.m. Identification of the Genetic Variant Responsible for Variable Platelet CD36 Expression By Massively Parallel Reporter Assay

Location: Room 31B, San Diego Convention Center

Presenter: Leonard Edelstein, Ph.D., Thomas Jefferson University

 

7:45 a.m. Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes
Location: Room 28D, San Diego Convention Center
Moderator: Claudia Morris, M.D., Emory University School of Medicine

8:00 a.m. Fatal Dysfunction and Fragmentation of Thrombin-Stimulated Platelets

Location: Room 31B, San Diego Convention Center

Presenter: Oleg Kim, Ph.D., University of Pennsylvania Perelman School of Medicine

 

8:00 a.m. Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited Anemia

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Kimberly Lezon-Geyda, Ph.D., Yale University School of Medicine

 

8:15 a.m. Polyclonal Immune Response in T-LGL Leads to Clonal Expansions Preceding Occurrence of STAT3 Mutations Further Solidifying Clonal Dominance

Location: Room 8, San Diego Convention Center

Presenter: Cassandra Hirsch, Cleveland Clinic Foundation

 

10:45 a.m. Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein

Location: Grand Ballroom 2, Marriott Marquis

Presenter: Raffaele Renella, M.D., Ph.D., University Hospital of Lausanne

 

11:45 a.m. Area-Based Socioeconomic Status and Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Outcomes: A CIBMTR Analysis

Location: Room 24B, San Diego Convention Center

Presenter: Kira Bona, M.D., M.P.H., Children's Hospital Boston

 

2:45 p.m. Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice

Location: Room 11B, San Diego Convention Center

Presenter: Philipp Rauch, M.D., Boston University School of Medicine

 

2:45 p.m. Multicenter Microbiota Analysis Indicates That Pre-HCT Microbiota Injury Is Prevalent across Geography and Predicts Poor Overall Survival

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Jonathan Peled, M.D., Ph.D., Memorial Sloan Kettering Cancer Center

 

2:45 p.m. Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Victor Tkachev, Ph.D., Seattle Children's Research Institute

 

3:00 p.m. Generation of iPSC-Derived Human Megakaryocytes for Flow Cytometric Detection of Platelet-Specific Alloantibodies

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Nanyan Zhang, M.D., Ph.D., BloodCenter of Wisconsin

 

3:00 p.m. Very Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy for Prevention of Viral Infection after Allogeneic T Cell Depleted Stem Cell Transplantation

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Pawel Muranski, M.D., Columbia University Medical Center

 

3:00 p.m. Early Clonal Hematopoiesis Detected in Gata2 heterozygosity By Color-Barcoding of Hematopoietic Stem Cells in Zebrafish

Location: Room 11B, San Diego Convention Center

Presenter: Serine Avagyan, M.D., Ph.D., Dana-Farber Cancer Institute - Boston Children's Hospital

 

3:15 p.m. Short-Acting Anti-VWF Aptamer Improves the Recovery and Survival, and Hemostatic Functions of Refrigerated Platelets

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Wenchun Chen, Ph.D., Emory University School of Medicine

 

3:30 p.m. Health Care Reimbursement and Service Utilization Among Medicare Beneficiaries with Multiple Myeloma Receiving Autologous Hematopoietic Cell Transplantation in Inpatient and Outpatient Settings

Location: Room 24B, San Diego Convention Center

Presenter: Neil Dunavin, M.D., University of Kansas Medical Center

 

3:30 p.m. Targeting Elastase with Alpha1 Anti-Trypsin Reduces Hyperalgesia in Mice with Sickle Cell Disease

Location: Room 29C, San Diego Convention Center

Presenter: Aithanh Nguyen, University of Minnesota

 

3:30 p.m. The Association between Transplant-Associated Thrombotic Microangiopathy and Calcineurin Inhibitor and Sirolimus Levels

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenter: Ang Li, M.D., University of Washington School of Medicine

 

3:45 p.m. Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: David Gibb, M.D., Ph.D., Cedars-Sinai Medical Center

 

3:45 p.m. Gvhd Is Sustained By T Cell Maintenance within Target Tissues: Insights from Clonal Tracking and Parabiosis

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Faruk Sacirbegovic Ph.D., University of Pittsburgh

 

4:00 p.m. Patrolling Monocytes Scavenge Endothelial Adherent Sickle Red Blood Cells in Sickle Cell Disease

Location: Pacific Ballroom 15, Marriott Marquis

Presenter: Karina Yazdanbakhsh, Ph.D., New York Blood Center

 

4:00 p.m. Effect of Chronic Opioid Therapy on Pain and Survival in a Mouse Model of Sickle Cell Disease

Location: Room 29C, San Diego Convention Center

Presenter: Varun Sagi, University of Minnesota

 

4:30 p.m. Targeting Sec23b in COPII Vesicles Regulates T Cell Immunity

Location: Room 8, San Diego Convention Center

Presenter: Stephanie Kim, B.S., University of Michigan Medical School

 

4:30 p.m. Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Location: Room 31B, San Diego Convention Center

Presenter: Moua Yang, Ph.D., Department of Biochemistry, Milwaukee

 

4:45 p.m. The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Katie Giger Seu, Ph.D., Cincinnati Children's Hospital Medical Center

 

4:45 p.m. Sickle Cell Subjects Have a Stronger and Faster Neurally Mediated Vasoconstriction Response to Cold Pain That Correlates with Anxiety Scores

Location: Room 25B, San Diego Convention Center

Presenter: Saranya Veluswamy, M.D., Children's Hospital Los Angeles

 

4:45 p.m. Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Location: Grand Hall A, Manchester Grand Hyatt

Presenter: Youmna Kfoury, Ph.D., Massachusetts General Hospital

 

4:45 p.m. Disruption of Tet2 Dioxygenase Enhances Antitumor Efficiency in CD8+ Tumor Infiltrating Lymphocytes

Location: Room 8, San Diego Convention Center

Presenter: Minjung Lee, M.S., Texas A&M University, Institute of Biosciences and Technology

 

5:00 p.m. Mitochondrial Regulation Is Essential for Erythroid Nuclear Clearance

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Raymond Liang, Ph.D., Icahn School of Medicine at Mount Sinai

 

5:00 p.m. Alpha-Granules in Resting Human Platelets Are a Spatially Clustered, Single Major Population

Location: Room 31B, San Diego Convention Center

Presenter: Brian Storrie, Ph.D., University of Arkansas for Medical Sciences

 

5:15 p.m. A Novel Role for Bst2 and E-Selectin in IFNg-Stimulated HSC Niche Relocalization

Location: Grand Hall D, Manchester Grand Hyatt

Presenter: Katie Matatall, Ph.D., Baylor College of Medicine

 

5:15 p.m. Manipulating Metabolic Plasticity By Targeting Pyruvate Kinase M2 in Platelets Inhibits Arterial Thrombosis

Location: Room 31B, San Diego Convention Center

Presenter: Manasa Nayak, Ph.D., University of Iowa

 

5:15 p.m. Bmi-1 Regulates Ex Vivo Self-Renewal of Human Erythroblasts

Location: Grand Hall C, Manchester Grand Hyatt

Presenter: Jayme Olsen, M.S., University of Rochester

 

5:30 p.m. Characteristics and Potential Biomarkers of Adult Sickle Cell Patients with Chronic Pain

Location: Room 25B, San Diego Convention Center

Presenter: Camila Albo, Augusta University

 

6:00 p.m. Long-Term Stability of the Adult Sickle Cell Quality of Life Measure (ASCQ-Me)​

Location: Hall GH, San Diego Convention Center

Presenters: Keesha Roach, Ph.D., R.N., University of Florida,

 

6:15 p.m. Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study)

Location: Room 29C, San Diego Convention Center

Presenters: Jeffrey Zwicker, M.D., Beth Israel Deaconess Medical Center Harvard Medical School

 

6:15 p.m. T-Replete Haploidentical Cell Transplantation Using Post-Transplant Cyclophosphamide for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome: Effect of Transplant Conditioning Regimen Intensity on Outcomes

Location: Seaport Ballroom A, Manchester Grand Hyatt

Presenters: Scott Solomon, M.D., BMT Group of Georgia

 

6:15 p.m. Gene Therapy for Sickle Cell Anemia Using a Modified Gamma Globin Lentivirus Vector and Reduced Intensity Conditioning Transplant Shows Promising Correction of the Disease Phenotype

Location: Room 6B, San Diego Convention Center

Presenters: Punam Malik, M.D., Cincinnati Children's Hospital

 

6:15 p.m. Prospective Diagnosis of VWD in a Large Cohort of Patients with Bleeding Symptoms through the Zimmerman Program

Location: Room 28D, San Diego Convention Center

Presenters: Veronica Flood, M.D., Medical College of Wisconsin

 

6:30 p.m. A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice 

Location: Room 29C, San Diego Convention Center

Presenters: Randolph Lyde, Ph.D., Perelman School of Medicine of the University of Pennsylvania

 

7:00 p.m. Single Cell RNA Sequencing of Blood Outgrowth Endothelial Cells from Patients with Low Von Willebrand Factor Reveal Multiple Novel Signaling Pathways

Location: Room 28D, San Diego Convention Center

Presenters: Christopher Ng, M.D., University of Colorado - Children's Hospital Colorado

 

7:15 p.m. Epigenetic Profiles of Primary Endothelial Cells from Patients with Low VWF Levels

Location: Room 28D, San Diego Convention Center

Presenters: Christopher Ng, M.D., University of Colorado - Children's Hospital Colorado