The goal of this workshop is to bring together experts to examine key challenges and proposed recommendations associated with the interface between the circulatory system and the brain. The workshop will cut across the interface and include sessions on upstream blood biomarkers as well as targeted drug delivery, highlighting the potential therapeutic role of exosomes for diagnostic applications as well as targeted drug delivery, and brain sequelae that release biomarkers into the circulation. A common theme that has emerged on both sides of the interface is the role of the immune system and the inflammasome. Sessions will discuss the broad state of the science at the Blood Brain Interface as well as examples of brain injury states (e.g. brain trauma, ischemic stroke, cancer, and neurodegenerative processes) and translational therapeutic developments in this space. The workshop will include experts from across the spectrum of the blood brain interface, not just limited to the blood-brain barrier, to highlight the promise and potential of technologies for diagnostics and therapy development, and encourage potential collaborations across the various groups represented at the meeting as well as generate a set of recommendations that could facilitate development in this promising field.
The Videocast of the Trans-Agency Blood Brain Interface Workshop 2016 can be viewed online:
Trans-Agency Blood Brain Interface Workshop 2016 (Day 1)
Tuesday, June 7, 2016, 8:00AM-5:00PM
Trans-Agency Blood Brain Interface Workshop 2016 (Day 2)
Wednesday, June 8, 2016, 8:00AM-1:30PM
To view the complete agenda click the link:
To view the complete final program click the link:
This 1½-day workshop brought together experts in blood science, blood-brain barrier (BBB) biology/modeling and BBB drug delivery. The experts presented their latest findings, examined key challenges, and developed recommendations for further studies on the connection between the circulatory system and the brain. The workshop featured four sessions: 1) Blood Sciences; 2) Exosome Therapeutics; 3) Next Generation in vitro Blood-Brain Barrier Models; and 4) Blood-Brain Barrier Delivery and Targeting. The first day focused on the physiology of the blood and neurovascular unit, biofluid-based molecular markers, and extracellular vesicles associated with brain injury. The sessions explored how these are transported between brain and blood and how they can be used to evaluate injury states or deliver therapeutics. The second day focused on technical advances in in vitro models, BBB manipulations, and nanoparticle-based drug carrier designs, as ways to improve drug delivery to the central nervous system. Each day concluded with a discussion among the speakers and workshop participants. Those interdisciplinary discussions, along with the presentations, highlighted the potential for developing technologies for BBB diagnostics and therapy, as well as the need for collaboration among the groups represented. The discussions also generated recommendations aimed at helping advance this promising, yet underrepresented, cross-disciplinary field.
Research Needs and Challenges
The speaker presentations and panel discussions highlighted several overarching research needs involving the interface between the blood and the brain. These can be grouped into the following three categories:
Recommendations and Opportunities
The speakers noted the following recommendations and opportunities:
As our understanding of both the complex interactions among the various cellular and molecular components of the BBB and the interdependency of the brain and other organ systems with BBB function grows, more opportunities to advance research that leads to new BBB diagnostic and treatment modalities will emerge.
Published in Fluids and Barriers of the CNS 14, Article number: 12 (2017)
Margaret Ochocinska, PhD
Translational Blood Science and Resources Branch
Division of Blood Diseases and Resources
Workshop Chairs and Session Chairs
Workshop Steering Committee