To build on the successes in fundamental discovery science and early-stage translational research, it is important to facilitate late-stage T4 translational research—the phase in the translational research pathway that leads to general knowledge about implementing evidence-based interventions—that helps turn discoveries into improved health. Successful execution of T4 translation research requires the transdisciplinary collaboration of diverse stakeholders across various sectors. Innovative platforms can be developed to solicit, nurture, and support team science while leveraging expertise from biomedical, behavioral, and social science research, as well as experts from engineering, bioinformatics, behavior economics, and the emerging field of big data science.
The Translation Research Branch (TRB) supports T4 translation research, a mission-critical area for CTRIS. This area of work supports investigations, with an emphasis on rigorous methodologies, to examine the adoption, uptake, acceptability, affordability, fidelity, and sustainability of proven-effective interventions guided by established implementation research frameworks. Strong emphasis on integrative multi-component systems analyses that identify innovative strategies to advance patient-centered and community-participatory intervention research is encouraged. Strategic trans-disciplinary research collaborations to advance late-stage T4 translation and knowledge transfer are crucial to this endeavor.
To support the NHLBI Strategic Vision and T4 translation research, the TRB aims to accelerate institute-solicited research applications that will help advance the rapid adoption and uptake of proven-effective interventions; leverage existing and new NIH investments in methodology, tools development, and training resources to advance implementation research at NHLBI; explore the use of innovative technologies and the emerging big data science for implementation research; and facilitate the use of existing datasets in networks such as those supported in PCORNet to advance implementation research.
T4 Research Program
This program serves as the core opportunity to support T4 translation research in heart, lung, blood, and sleep disorders, with implementation research outcomes as primary endpoints. This program will advance our understanding of implementation strategies across diverse patient populations and health systems. It also will significantly impact care of heart, lung, blood, and sleep disorders by decreasing the ‘gap in translation’ from clinical trials and academic centers to communities where most health services are delivered.
Small Business Topic of Special Interest Program
This program leverages the Institute’s Small Business grant mechanisms to support the development of innovative technology, service delivery models, or designs to increase the adoption, uptake, and sustainability of evidence-based guideline recommendations for the management of heart, lung, blood, and sleep disorders. These technologies or service delivery models should include multi-level (health systems, provider, and patient) facets and benefit certain populations, such as racial or ethnic minority groups, rural populations, and low socioeconomic status groups.