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Cardiovascular Regenerative Medicine Symposium

Wednesday, September 27, 2017

7:00 a.m.     Registration                                                           

 

 

8:00 a.m.    Welcome and Opening Remarks

                   Manfred Boehm, M.D.

                   National Heart, Lung, and Blood Institute

 

 

8:05 a.m.    Remarks from the NHLBI Director

                   Gary H. Gibbons, M.D.

                   National Heart, Lung, and Blood Institute

 

8:15 a.m.    Keynote Address

                  Cellular Reprogramming Approaches for Cardiovascular Disease

                   Deepak Srivastava, M.D.

                   Gladstone Institute of Cardiovascular Disease

                   University of California, San Francisco

 

9:00 a.m.    Session I: Stem Cell Biology

                  Moderators: Charles E. Murry, M.D., Ph.D., and Victor J. Dzau, M.D.

 

9:05 a.m.    Epigenetic Regulation, Stem Cells, and Disease Relevance

                   Rudolf Jaenisch, M.D.

                   Whitehead Institute for Biomedical Research

                   Massachusetts Institute of Technology

9:25 a.m.    Leveraging the Translation of iPS Cells

                   Ilyas Singeç, M.D., Ph.D.

                   National Center for Advancing Translational Sciences

 

9:45 a.m.    Therapeutic Targeting of Mesenchymal Stem/Stromal Cells in the Adult Mammalian Heart

                   Richard P. Harvey, Ph.D.

                   Victor Chang Cardiac Research Institute

                   University of New South Wales

10:05 a.m.    Chromatin Remodeling and Vascular Fate

                     Courtney Griffin, Ph.D.

                    Oklahoma Medical Research Foundation

10:25 a.m.    Panel Discussion

 

10:45 a.m.    Break

 

11:00 a.m.    Session II: Cardiovascular Development

                    Moderators: Beth Kozel, M.D., Ph.D., and Laura Niklason, M.D., Ph.D.

 

11:05 a.m.    Regulation of Cardiopharyngeal Fate Specification in a Simple Chordate

                     Lionel Christiaen, Ph.D.

                    New York University

 

11:25 a.m.    Development of the Cardiopharyngeal Lineage in Zebrafish

                     Caroline E. Burns, Ph.D.

                     Harvard Medical School

                    Massachusetts General Hospital

 

11:45 a.m.    Generation of Atrial and Ventricular Cardiomyocytes From Human Pluripotent Stem Cells

                     Gordon M. Keller, Ph.D.

                    University Health Network, Toronto

12:05 p.m.    Mechanisms of Endothelial Cell Regeneration

                     Luisa Iruela-Arispe, Ph.D.

                    University of California, Los Angeles

 

12:25 p.m.    Panel Discussion

 

12:45 p.m.    Lunch (on your own)

 

1:30 p.m.    Session III: Translational Cardiovascular Stem Cell Biology I

                   Moderators: Manfred Boehm, M.D., and Denis Buxton, Ph.D.

 

1:35 p.m.    Allogeneic Transplantation Study of iPS Cell-Derived Cardiomyocytes Regenerates Primate Heart

                   Yuji Shiba, M.D., Ph.D.

                   Institute for Biomedical Sciences

                   Shinshu University

 

1:55 p.m.    Vascular Progenitor Cells in Engineered Tissues

                   Laura Niklason, M.D., Ph.D.

                  Yale School of Medicine

 

2:15 p.m.    Maturation of Stem Cell-Derived Cardiomyocytes

                   Charles E. Murry, M.D., Ph.D.

                  University of Washington

2:35 p.m.    The Emerging Application of Stem Cells in Congenital Heart Disease Patients

                   Sunjay Kaushal, M.D., Ph.D.

                  University of Maryland Medical Center

 

2:55 p.m.    Panel Discussion

 

3:15 p.m.    Break

 

3:30 p.m.    Poster Session

 

5:30 p.m.    Adjourn


Thursday, September 28, 2017

 

7:00 a.m.    Registration

 

8:00 a.m.    Session IV: Translational Cardiovascular Stem Cell Biology II

                  Moderators: Jason Kovacic, M.D., Ph.D., and Caroline E. Burns, Ph.D.

 

8:05 a.m.    Regeneration of the Infarcted Pig Heart With Human Pluripotent Stem Cell-Derived

                  Cardiomyocytes

                   Michael Laflamme, M.D., Ph.D.

                   University Health Network, Toronto

                   University of Toronto

 

8:25 a.m.    Stem Cells and Genomics for Precision Medicine

                   Joseph C. Wu, M.D., Ph.D.

                   Stanford University School of Medicine

 

8:45 a.m.    Large-Scale GMP-Compatible Production of Stem Cell-Derived Cardiomyocytes

                   Joseph Gold, Ph.D.

                   Beckman Research Institute

 

9:05 a.m.    Generation and Functional Characterization of Sodium Iodide Symporter

                  Transgenic Rhesus-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

                   Cynthia E. Dunbar, M.D.

                  National Heart, Lung, and Blood Institute

 

9:25 a.m.    Panel Discussion

 

9:45 a.m.    Break

 

10:00 a.m.    Session V: Endogenous Heart Regeneration

                    Moderators: Manfred Boehm, M.D., and Joshua Hare, M.D.

 

10:05 a.m.    Redox Regulation of Cardiomyocyte Renewal

                     Hesham Sadek, M.D., Ph.D.

                    The University of Texas Southwestern Medical Center

 

10:25 a.m.    An Evolutionarily Conserved Pathway of Heart Regeneration

                    Richard T. Lee, M.D.

                    Harvard University

 

10:45 a.m.    Innate Heart Regeneration

                    Kenneth D. Poss, Ph.D.

                    Duke University Medical Center

 

11:05 a.m.    Hippo Signaling in Heart Regeneration

                    James F. Martin, M.D., Ph.D.

                    Baylor College of Medicine

                    Texas Heart Institute

 

11:25 a.m.    Panel Discussion

 

11:45 a.m.     Lunch (on your own)

 

12:30 p.m.    Session VI: New Technologies and Models                       

                    Moderators: Joseph Gold, Ph.D., and Ilyas Singeç, M.D., Ph.D.

 

12:35 p.m.    New Strategies for Accelerating Cardiac Regeneration

                     Nadia Rosenthal, Ph.D., F. Med. Sci., FAAHMS

                    The Jackson Laboratory (Bar Harbor, Maine)

 

12:55 p.m.    DNA Sequence Variations in iPSCs

                     Paul Liu, M.D., Ph.D.

                    National Human Genome Research Institute

 

1:15 p.m.    Human Pluripotent Stem Cells in Understanding Genetic Cardiovascular Disease and Effects of Drugs

                   Christine Mummery, Ph.D.

                   Leiden University Medical Center

 

1:35 p.m.    Genome Engineering in Human iPS Cells to Model and Treat Disease

                   Bruce R. Conklin, M.D.

                  Gladstone Institute of Cardiovascular Disease

                  University of California

 

1:55 p.m.    Panel Discussion

 

2:15 p.m.    Session VII: Clinical Translation Roundtable Discussion

                   Moderators: Joseph C. Wu, M.D., Ph.D., and Cynthia E. Dunbar, M.D.

 

2:20 p.m.    Lessons from Current Trials That Can Guide the Design of Pivotal Trials

                   Joshua Hare, M.D.

                   University of Miami Miller School of Medicine

 

2:40 p.m.    The Regulatory Approach for Cardiopoietic Stem Cell Therapy

                   Atta Behfar, M.D., Ph.D.

                   Mayo Clinic Graduate School of Biomedical Sciences

 

3:00 p.m.     Future Directions in Cell Therapy

                    Denis Buxton, Ph.D.

                   National Heart, Lung, and Blood Institute

 

3:20 p.m.    Regenerative Medicine Provisions of the 21st Century Cures Act: Catalyst for Partnerships and Innovation

                   Amy P. Patterson, M.D.

                   National Heart, Lung, and Blood Institute

3:40 p.m.    Jason Kovacic, M.D., Ph.D.

                   Ichan School of Medicine

                   Mount Sinai Medical Center

 

4:00 p.m.    Closing Remarks

 

4:05 p.m.    Adjourn

                   Bruce Conklin, M.D.

                   Gladstone Institute of Cardiovascular Disease

 

1:55 p.m.    Panel Discussion

2:15 p.m.    Session VII: Clinical Translation Roundtable Discussion

                   Moderators: Joseph C. Wu, M.D., Ph.D. and Cynthia Dunbar, M.D.

 

2:20 p.m.    Victor J. Dzau, M.D.

                   National Academy of Medicine

 

2:40 p.m.    Jason Kovacic, M.D., Ph.D.

                   Ichan School of Medicine

                    Mount Sinai Medical Center

 

3:00 p.m.    Joshua Hare, M.D.

                   University of Miami Miller School of Medicine

 

3:20 p.m.    Denis Buxton, Ph.D.

                   National Heart, Lung, and Blood Institute

 

3:40 p.m.    Panel Discussion

 

4:00 p.m.    Closing Remarks

 

4:05 p.m.    Adjourn