NHLBI SBIR/STTR Contract Topic
069 Wireless Physiologic Telemetry for
(Fast-Track proposals will be accepted)
Number of anticipated awards: 1
Magnetic resonance imaging (MRI) has potential to
revolutionize minimally invasive surgery and
interventional procedures by affording improved
tissue visualization without conventional surgical
incisions. Many such procedures will be conducted
under both X-ray and MRI guidance. Such procedures
require high fidelity hemodynamic recording of
physiological signals such as electrocardiography
and invasive blood pressure, with seamless
bidirectional transfer between X-ray and MRI. To
date there are no suitable commercial solutions.
A wireless telemetry system would allow
acquisition of hemodynamic signals (multichannel
electrocardiography, invasive blood pressure,
noninvasive hemoglobin saturation, temperature,
etc.) safely in both the MRI and X-ray fluoroscopy
environments, and allow continuous monitoring during
transportation between the two.
The system must conform to the following
- The system must operate safely at MRI field
strengths of 1.0T to 3.0T. • The system must
record and transmit signals with the patient
inside the magnet bore during imaging.
- The system should filter MRI-specific noise
(e.g. radiofrequency pulses and gradient
switching) and be robust to a range of rapid
pulse sequences with continuous duty cycle,
including single and multi-slice real-time,
three-dimensional gradient echo, balanced steady
state free precession, and (non-real-time) turbo
spin echo techniques. The system must be able to
filter noise from low frequency events, such as
spoiler gradients or magnetization preparation
- The system should provide ten electrodes for
diagnostic electrograms (four limb, six chest)
under an X- ray environment and at least six
(four limb, two chest) under an MRI environment.
The electrode and lead system should be safe for
operation under MRI, resistant to inadvertent
loop formation, and should be radiolucent for
operation under X-ray.
- The system should allow transduction of two
simultaneous channels of invasive blood pressure
from fluid- filled catheters, ideally with
commonly used clinical invasive blood pressure
- The system should measure continuous
noninvasive hemoglobin oxygen saturation.
- All physiological signals should be
aggregated in a single unit for wireless
telemetry. Signals must be received in at least
one base station in each modality, (one in X-ray
and another in MRI), with automatic handoff from
one to the other. Base stations should connect
to popular commercial hemodynamic recording
systems (specifically Siemens Sensis and General
- The system should provide for uninterrupted
operation for at least 6 hours.
- The system should NOT generate
radiofrequency noise that interferes with MRI.
The system should not interfere with common
commercial Bluetooth and other common
radiofrequency patient physiologic telemetry
systems used during MRI.
Proposals to address electrocardiogram artifacts
from magnetohydrodynamic effects are welcomed but
The sponsoring NIH laboratory is willing to
provide access to acquired physiological signals
without preprocessing; alternatively the offeror
should have access to such a laboratory
independently for development and for testing.
The Phase I deliverable is a working prototype to
support investigational X-ray and MRI guided
interventional procedures in patients. This includes
ten ECG leads for use in X-ray and at least six ECG
leads for use in MRI, two invasive pressure
transducers, and hemoglobin saturation.
The Phase II deliverable is a commercial-grade
For more information, see the
FY2012 Contract Solicitation
or contact OTAC.
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Last Updated December 2011