Prognosis and treatment for aplastic anemia require tailoring based on which mutations patients have among a handful of leukemia-related genes, according to a new study from researchers including NHLBI's Dr. Neal S. Young.
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NIH Seeks Comment on Agency-wide Strategic Plan
In response to a request from the Congress, NIH is developing a 5-year NIH-wide Strategic Plan to advance its mission to support research in pursuit of fundamental knowledge about the nature and behavior of living systems, and the application of that knowledge to extend healthy life and reduce illness and disability. Senior leadership and staff from all 27 Institutes, Centers, and Offices (ICOs) are contributing to the proposed direction and content of the Strategic Plan, with input from the Advisory Committee to the Director, NIH.
High-resolution 3D images reveal the muscle mitochondrial power grid
A new study overturns longstanding scientific ideas regarding how energy is distributed within muscles for powering movement. Scientists are reporting the first clear evidence that muscle cells distribute energy primarily by the rapid conduction of electrical charges through a vast, interconnected network of mitochondria—the cell’s “powerhouse”—in a way that resembles the wire grid that distributes power throughout a city. The study offers an unprecedented, detailed look at the distribution system that rapidly provides energy throughout the cell where it is needed for muscle contraction.
Featured Fact Sheet
In 2010, Afia Donkor, a young woman from Canada, struggled to walk a few blocks from her home to a subway station in Montreal on her way to the airport. Suitcase in hand, she moved at a snail’s pace as she experienced severe exhaustion due to a flare-up of her sickle cell disease. One step at a time, she finally made it, propelled by the hope of a new treatment that awaited her at the other end of her journey to the United States. Read full fact sheet...
NHLBI's Dr. Toren Finkel joined a live radio panel discussion on the Diane Rehm Show to discuss his anti-aging research involving work on mice. Other panel members included National Institute on Aging's Dr. Mark Mattson and Massachusetts Institute of Technology's Leonard Guarente.