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HDL < 15 mg/dL Research Studies

Hypoalphalipoproteinemia Research Study - Diagnosis and Followup Protocol

If you have hypoalphalipoproteinemia with a high density lipoprotein (HDL) <15 mg/dL, you are invited to participate in a study in an attempt to diagnose and follow your disorder. There are several known causes of low HDL and they include Tangier disease, LCAT deficiency, and Fish Eye disease. However, many causes of low HDL have yet to be discovered. You are not eligible for participation if you have other causes of lipid disorders that lead to low HDL such as liver and thyroid disorders. You are not eligible if you have the "metabolic syndrome" with obesity, hypertension, diabetes, and hypertriglyceridemia (triglycerides >500 mg/dL) with an HDL that ranges from 10-15 mg/dL. 

Eligible persons will undergo a comprehensive evaluation at no cost to you. All patients will remain under the care of their own physician who will receive results of the laboratory and diagnostic tests. In many cases, you will be invited back for yearly evaluations related to other studies. There is no cost to you for travel and for some of your medications. 

For further information please contact our research coordinator (tel. 301-496-1500, e-mail: bobs@mail.nih.gov). 

Last Updated: April 13, 2017