Vascular Thrombosis and Inflammation

The Laboratory of Vascular Thrombosis and Inflammation, led by Dr. Yogen Kanthi, studies disease mechanism in venous thrombosis with a major area of focus on regulation of venous homeostasis. Dr. Kanthiexplores endogenous vasculo-protective enzymes that function at the intersection of inflammation and coagulation.

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Research Interests

Research Interests

As a cardiologist and clinical vascular medicine specialist, Dr. Kanthi’s laboratory aims to understand how inflammation and coagulation contribute to vascular disease. We are interested in developing a deeper understanding of how innate immune circuits and communicate with coagulation and the vessel wall to license or restrict thrombosis.

Dr. Kanthi joined the NIH to build a translational vascular medicine research program. His team has studied the role of inlammasome activation and purine signaling in venous thrombosis (JCI, ATVB, Nature Communications). The Laboratory of Vascular Thrombosis and Inflammation (LVTI)has made seminal discoveries in COVID-19 pathology, being the first to identify neutrophil extracellular traps in patients with COVID-19 (JCI Insight), a new calprotectin biomarker for COVID-19 severity (J Leuk Biol), and the discovery of prothrombotic autoAntibodies in patients with COVID-19 (Science Translational Medicine).

With expertise in thrombo-inflammation and vascular biology, Dr. Kanthi launched a clinical trial at the University of Michigan (NCT04399179) to test dipyridamole, a repurposed FDA-approved drug in patients with COVID-19.

The goal of the LVTI is to identify the molecular and cellular processes that lead to vascular thrombo-inflammation and design better therapeutic approaches for patients with vascular disease.

 

Journal Covers

JCI 2019
Journal of Clinical Investigation 2019

Our team studies disease mechanisms in venous thrombosis with a major area of focus on regulation of venous homeostasis. We investigate endogenous molecules like the prototypical inflammasome effector interleukin-1β, and vasculo-protective purinergic enzymes at the intersection of inflammation and coagulation.


 

JCI Insight 2020
JCI Insight 2020

We are investigating the molecular and cellular mechanisms that contribute to COVID-19 severity. Working closely with our collaborator, Dr. Jason Knight, we were the first to describe the role of neutrophil activation and extracellular trap formation in COVID-19. Our findings have led to several clinical trials, and been validated by several groups.

Additional Coverage: Scientific American


STEM 2020
Science Translational Medicine 2020

We leverage our strengths in inflammation and thrombosis , two processes at the heart of severe COVID-19 illness to understand this disease, and develop potential new treatments. We are also interested in disease pathways that are triggered by abnormal innate immune activation and cell stress responses.  Our team discovered that COVID-19 triggers the production of prothrombotic autoantibodies in blood. Our work utilizes human blood, tissues from patients with vascular disease, primary cultures endothelial cells, and mouse models of venous thrombosis.

Additional Coverage: NIH Director's Blog, TIME

Featured Publications

Neutrophil extracellular traps and thrombosis in COVID-19.

Authors: Zuo Y, Zuo M, Yalavarthi S, Gockman K, Madison JA, Shi H, Woodard W, Lezak SP, Lugogo NL, Knight JS, Kanthi Y.
J Thromb Thrombolysis. 2020 Nov 05;Online ahead of print:1-8
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Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19.

Authors: Zuo Y, Estes SK, Ali RA, Gandhi AA, Yalavarthi S, Shi H, Sule G, Gockman K, Madison JA, Zuo M, Yadav V, Wang J, Woodard W, Lezak SP, Lugogo NL, Smith SA, Morrissey JH, Kanthi Y, Knight JS.
Sci Transl Med. 2020 Nov 02;Online ahead of print:eabd3876
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Neutrophil calprotectin identifies severe pulmonary disease in COVID-19.

Authors: Shi H, Zuo Y, Yalavarthi S, Gockman K, Zuo M, Madison JA, Blair C, Woodward W, Lezak SP, Lugogo NL, Woods RJ, Lood C, Knight JS, Kanthi Y.
J Leukoc Biol. 2020 Nov 01;Online ahead of print:
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COVID-19-associated coagulopathy: An exploration of mechanisms.

Authors: Colling ME, Kanthi Y.
Vasc Med. 2020 Oct 01;25(5):471-478
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Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Authors: Zuo Y, Warnock M, Harbaugh A, Yalavarthi S, Gockman K, Zuo M, Madison JA, Knight JS, Kanthi Y, Lawrence DA.
medRxiv. 2020 Sep 02;Preprint:2020.08.29.20184358
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Meet the Team

kanthi

Yogen Kanthi, M.D.

Lasker Clinical Research Scholar

Dr. Kanthi completed his residency training Internal Medicine at University Hospitals Case Western Reserve University, and served as the Department's Chief Medical Resident in 2008, after which he joined the University of Michigan for a Cardiovascular Medicine and a Vascular Medicine fellowship. Dr. Kanthi did an NIH-funded post-doctoral research fellowship with Dr. David J. Pinsky in vascular biology focused on mechanotransduction and atherosclerosis in arteries.

Following his research fellowship, he did a year of dedicated clinical vascular medicine training during which he recognized the need for advancement in treatments for patients with venous thrombosis (DVT) and peripheral artery disease (PAD). Dr. Kanthi joined the faculty of the University of Michigan in 2014, and has made DVT and PAD the focus of his translational research laboratory. As a faculty member, he has been awarded a Young Physician Scientist Award by the American Society of Clinical Investigation. His academic interests focus on understanding the pathological processes that lead to innate immune activation in venous thrombosis, vein graft disease, and mechanotransduction in the vessel wall. Dr. Kanthi is board certified in Internal Medicine, and Cardiovascular Medicine.

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Jintao Wang, M.D.

Staff Scientist
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Wyatt Becicka, M.S.

Postbaccalaureate Fellow