Recipient Epidemiology and Donor Evaluation Study (REDS) Program
What is the goal of the REDS program?
The goal of the REDS program is to evaluate and improve the safety and availability of the blood supply and the safety and effectiveness of transfusion therapies. The program also works to proactively address potential emerging threats to the Nation's blood supply and serves as a resource for ongoing work in transfusion research. Now in its fourth phase, the Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) program aims primarily at improving the benefits of transfusion while reducing its risks; the REDS program also has a new focus on previously understudied populations.
Over the past 30 years, REDS has been the premier research program in blood collection and transfusion safety in the United States. In its third phase — REDS-III — the program focused on conducting research on all elements of the transfusion chain, from the blood donor to the blood products made from their donation to the adult patients receiving the products through transfusion. The program compiled these linked demographic, clinical, and laboratory data on blood donors and recipients into comprehensive databases that are available through NHLBI's Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC).
REDS-IV-P builds on REDS-III with an additional focus on research with newborns, children, and pregnant women who need transfusions. The data compiled in REDS-IV-P will allow investigators to rapidly address key research questions in transfusion medicine and inform blood policy decisions, for adults as well as for children and other understudied patient populations.
REDS-IV-P also extends the Brazilian sickle cell disease cohort that was established in REDS-III to evaluate transfusion practices and associated clinical outcomes in sickle cell disease. The REDS-IV-P Brazilian transfusion program will also continue its monitoring and surveillance efforts for Zika, chikungunya, dengue, and other emerging viral threats to the blood supply.
AT A GLANCE
- REDS protects the Nation’s blood supply through research to improve blood component safety and availability and the safety and effectiveness of transfusions.
- The REDS program was launched by the NHLBI in 1989 and has had three additional phases: REDS-II, REDS-III, and REDS-IV-P.
- Internationally, REDS seeks to reduce and prevent the transmission of HIV and infectious agents, such as dengue and Zika viruses, through blood transfusion.
- REDS-III began integrating adult transfusion recipient epidemiology and laboratory research to enhance the safety of transfusions.
- REDS-IV-P expands the work of REDS-III to include newborns, children, and pregnant women who receive transfusions in the United States.
How does the REDS program contribute to scientific discovery?
The program has established scientific approaches to assessing the risks of contracting transfusion-transmitted infectious agents, established databases to evaluate the blood supply as well as specific populations of transfused patients, and added shareable biorepository resources for the scientific community.
More Information
- Recipient Epidemiology and Donor Evaluation Study (REDS) Program
How is the REDS-IV-P program conducted?
The U.S. component of the REDS-IV-P program has four research hubs. Each hub has a blood center and offers transfusion services to support health care and community hospitals. The international component involves collaborations between U.S. and Brazilian researchers. The research activities of all REDS-IV-P hubs are supported by a data coordinating center (Westat, Maryland) and a center for transfusion laboratory studies (Vitalant Research Institute, California).
The REDS-IV-P program will serve as a resource to the scientific community by giving investigators outside the program opportunities that include:
- Collaborating with REDS-IV-P researchers.
- Accessing biospecimens and scientific expertise.
- Analyzing data on transfusion and transfusion-associated outcomes in patient populations that are otherwise not available in the United States.
Another important part of the collaborative research effort in REDS-IV-P is the training of junior investigators in blood banking and transfusion medicine research. This enables the NHLBI to build research capacity in an area of tremendous global public health importance.
FEATURE
On June 14, the National Heart, Lung, and Blood Institute (NHLBI) joins the World Health Organization (WHO) in observing World Blood Donor Day.
Simone Glynn, M.D., M.P.H., chief of the Blood Epidemiology and Clinical Therapeutics Branch in NHLBI’s Division of Blood Diseases and Resources, and Shimian Zou, Ph.D., a senior scientific officer for international blood science and an HIV/AIDS program coordinator there, answer questions about donating blood, the safety and availability of the blood supply, and ongoing research.
RELATED NEWS
A new study by researchers at the National Institutes of Health and their colleagues has found that SARS-CoV-2, the virus that causes COVID-19, does not appear to pose a threat to the safety of the nation’s blood supply. The analysis, published in Transfusion, supports current donor screening guidelines, including those used by the U.S. Food and...