Xing Fan, MD., PhD.

Dr. Fan is a hematologist who studies the genetics, molecular biology, immunology, and clinical management of bone marrow failure syndromes, allogeneic stem cell transplantation, and hematological malignancies. She participates in clinical trials focused on both transplant and non-transplant treatments for aplastic anemia, and management for other hematology diseases. Additionally, she works with non-human primate models to study hematopoiesis, disease mechanisms, and pre-clinical development.

Dr. Fan earned her MD and PhD at Shanghai Jiao Tong University, School of Medicine, and the Shanghai Institute of Hematology, where she studied the genetics and molecular biology of acute myeloid leukemia, immunology and hematopoietic cell transplantation (HCT) treatments in hematologic malignancies, as well as advanced clinical and pre-clinical studies in lymphoma. She trained as an internal medicine resident and as a hematology/HCT transplant fellow at Shanghai Ruijin Hospital, where she also served as a staff clinician. In 2016, Dr. Fan joined the National Heart, Lung, and Blood Institute as a postdoctoral fellow, later becoming a research fellow. Her research focused on hematopoiesis in non-human primate models and the analysis and summary of clinical trials related to bone marrow failure syndromes, including aplastic anemia and Diamond-Blackfan anemia. In 2022, she was enrolled in the NCI/NHLBI Hematology-Oncology Fellowship as a clinical fellow and graduated in 2024. Dr. Fan is currently involved in the clinical management of HCT and classic hematology patients. She is also actively engaged in translational studies on bone marrow failure diseases and in-vivo cell therapy in the Laboratory of Molecular Hematopoiesis and the Laboratory of Transplantation Immunotherapy.

Publications

Clonal tracking of erythropoiesis in rhesus macaques

Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias

Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell-extrinsic contributions to erythropoiesis