We propose to characterize the etiology and natural history of rare and uncommon diseases, both known and unknown that present with symptoms and signs associated with the risk of overt or potential cardiovascular dysfunction. We will also study rare genetic modifiers and identify novel disease mechanisms contributing to common cardiovascular diseases. In so doing, we will expand our knowledge about these disorders and provide access to subjects of interest for research, teaching, and clinical experience. Individual subjects seen under this protocol may initiate the establishment of specific
A caloric restricted diet has numerous health effects including the reduction in numerous cardiovascular disease risk factors. The cellular programs activated by caloric restriction are similarly turned on in preclinical studies in response to a 24-hour fast. We found that a beneficial effect of a 24-hour fasting blunted the activation of a component of the immune system, termed the NLRP3 inflammasome, which is associated with the development of diabetes and atherosclerosis. This clinical protocol was developed to study this inflammasome in human blood cells to evaluate whether the beneficial
Psoriasis causes chronic inflammation in the body. Our study will explore if a kind of vitamin B3 dietary supplement, nicotinamide ribosome can improve immune system function in the blood and skin of people with mild to moderate psoriasis. This in turn may lead to more treatment options. Eligible participants may call the Office of Patient Recruitment at 1-800-411-1222.