Laboratory of Critical Illness Pathogenesis and Therapeutics

The Laboratory of Critical Illness Pathogenesis and Therapeutics, led by Dr. Jeffrey Strich, focuses on understanding the pathogenesis and developing novel host-directed therapies targeting the dysregulated innate immune response that occurs during infections that cause critical illness. 

Jeff Strich

Senior Investigator Research Interests

Research Interests

Dr. Strich’s research interests are focused on developing therapies for and understanding the role of the innate immune system in infections that cause critical illness through human clinical trials, large animal models and ex vivo translational studies with a particular focus on bacterial sepsis and SARS-CoV-2 infection. Dr. Strich is particularly interested in studying the contribution and therapeutics targeting low-density neutrophils (LDNs), a subset of neutrophils traditionally identified in the peripheral blood mononuclear cell (PBMC) fraction of gradient density separation.  

Meet the Team

Jeff Strich

Jeffrey R. Strich, MD, M.H.S.

Lasker Clinical Research Scholar, Tenure Track Investigator

Dr. Strich received his undergraduate degree from the University of Connecticut in Molecular and Cell Biology, his degree in Medicine from the Uniformed Services University of the Health Sciences, and his Masters in Health Services in Clinical Research from the Duke University School of Medicine. He completed residency training in Internal Medicine at Georgetown University Hospital and then completed a combined fellowship in Critical Care Medicine and Infectious Diseases at the National Institutes of Health.

Dr. Strich is a Medical Officer in the United States Public Health Services Commissioned Corps. Prior to pursuing his degree in Medicine he served as a Special Assistant in the Office of the Surgeon General. Dr. Strich is a member of the Infectious Disease Society of America (IDSA) the Society of Critical Care Medicine, and serves on the editorial board of Critical Care Explorations. He holds an appointment as an Adjunct Assistant Professor of Medicine at the Uniformed Services University of the Health Sciences.