Using cutting edge imaging and spectroscopic technologies combined with novel lipidomic and proteomic approaches, investigations in the Laboratory of Host-Pathogen Dynamics, led by Dr. Nihal Altan-Bonnet, have been at the forefront of understanding the virus-host interface, revealing novel replication and transmission mechanisms shared by many different human viruses.
The Laboratory of Host-Pathogen Dynamics is comprised of a multidisciplinary team of investigators combining tools of cell and molecular biology, virology and immunology along with high-resolution imaging to understand how viruses transmit themselves effectively among hosts and establish successful infections.
In particular, my lab has revealed novel roles for host membranes in mediating successful viral replication and transmission.
How coronaviruses get out of cells using lysosomes (Ghosh et al., Cell 2020)
Electron micrograph of SARS-COV2 particles inside lysosomes
A new form of viral transmission: viruses travel in clusters inside extracellular vesicles ( Santiana et al., Cell Host and Microbe 2018)
Host lipids PI4P, cholesterol are hijacked by RNA viruses to facilitate their replication ( Altan-Bonnet., Trends in Cell Biology 2016)
Dr. Nihal Altan-Bonnet received her B.A. in biology and chemistry from Hunter College, New York in 1992 and her Ph.D. in cell biology from The Rockefeller University in 1998. She then conducted postdoctoral research with Dr. Jennifer Lippincott-Schwartz at the National Institute of Child Health and Development at the NIH from 1999 to 2005 before receiving a faculty position in the department of biological sciences at Rutgers University. In 2013, Dr. Altan-Bonnet returned to the NIH as an Earl Stadtman Investigator, becoming head of the Laboratory of Host-Pathogen Dynamics at the NHLBI and was promoted to tenured Senior investigator in 2017. Dr. Altan-Bonnet has been recognized several times for her outstanding research, receiving the Presidential Early Career Award in Science and Engineering (PECASE) in 2012, being named the John J. Holland lecturer at the American Society of Virology in 2017, and receiving the Norman Salzman Mentor Award in Virology in 2018. Dr. Altan-Bonnet was also named a Kavli Fellow and Scialog Fellow from 2013-2016. She is an Associate editor at the Molecular Biology of the Cell and is a member of the American Societies for Virology, Microbiology, and Cell Biology.