Epithelial Systems Biology

Research in the Epithelial Systems Biology Laboratory, led by Dr. Mark A. Knepper, concentrates on the physiology and pathophysiology of the kidney, with particular focus on regulation of water and salt transport by the peptide hormone vasopressin.

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Senior Investigator Research Interests

Research Interests

The Epithelial Systems Biology Laboratory, headed by Mark Knepper, uses systems biology-based approaches to study how the kidney regulates water excretion. This involves use of large-scale data acquisition techniques, such as protein mass spectrometry and ‘next-generation’ DNA sequencing technologies to discover molecular mechanisms involved in renal water transport. Much of the focus is on regulation of molecular water channels (aquaporins) by the hormone vasopressin in renal collecting duct epithelial cells. The Epithelial Systems Biology Laboratory is a small close-knit group of scientists devoted to development and exploitation of cutting-edge experimental and computational tools for these studies.

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Featured Publications

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of Mouse.

Authors: Chen L, Chou CL, Knepper MA.
J Am Soc Nephrol. 2021 Mar 04;32(4):897-912
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Targeted Single-Cell RNA-seq Identifies Minority Cell Types of Kidney Distal Nephron.

Authors: Chen L, Chou CL, Knepper MA.
J Am Soc Nephrol. 2021 Mar 04;32(4):886-896
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Phosphoproteomic identification of vasopressin-regulated protein kinases in collecting duct cells.

Authors: Datta A, Yang CR, Salhadar K, Park E, Chou CL, Raghuram V, Knepper MA.
Br J Pharmacol. 2021 Mar 01;178(6):1426-1444
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NGS-Integrator: An efficient tool for combining multiple NGS data tracks using minimum Bayes' factors.

Authors: Wen B, Jung HJ, Chen L, Saeed F, Knepper MA.
BMC Genomics 2020 Nov 19;21(1):806
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Transcriptomes of Major Proximal Tubule Cell Culture Models.

Authors: Khundmiri SJ, Chen L, Lederer ED, Yang CR, Knepper MA.
J Am Soc Nephrol. 2021 Jan 01;32(1):86-97
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Meet the Team

knepper

Mark Knepper, M.D., Ph.D.

Senior Investigator

Mark Knepper received a B.S. in chemical engineering from the University of Michigan, a Ph.D. in biomedical engineering, and a M.D. from Case Western Reserve University (CWRU), and has an honorary Ph.D. from the University of Aarhus in Denmark. He has been a NIH scientist since 1978 and is currently head of the Epithelial Systems Biology Laboratory at the NHLBI. Dr. Knepper has received the H.W. Smith Award (the highest award of the American Society of Nephrology), the R.W. Berliner Award at Yale University, the C.W. Gottschalk Award of the American Physiological Society, the Hugh Davson Lectureship of the American Physiological Society, and the D.W. Seldin Lectureship of the American Heart Association (Council on the Kidney in Cardiovascular Disease). He has published over 400 peer-reviewed papers on renal physiology, hypertension, nephrology, and systems biology. His editorial positions have spanned the American Journal of Physiology, and the Journal of Clinical Investigation. Dr. Knepper is a member of the American Heart Association, American Physiological Society, American Association for the Advancement of Science, American Society of Nephrology, and Biomedical Engineering Society.

Park

Euijung Park, PhD

Visiting Fellow
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Hiroaki Kikuchi, MD, PhD

Visiting Postdoctoral Fellow
Khan

Brian Poll, Ph.D

Postdoctoral Fellow
Leo

Kirby Leo, Ph.D.

Postdoctoral Fellow
Mehta

Yash Mehta

Postbaccalaureate Fellow
Lewis

Spencer Lewis

Postbaccalaureate Fellow
Shaza Khan

Shaza Khan

Special Volunteer
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Syed Jalal Khundmiri, Ph.D.

Special Volunteer
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