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The Electron Microscopy Core provides advice, technical services, training and use of facilities to NHLBI DIR investigators who require electron microscopy (EM) to answer specific research topics. In general, this refers to questions involving subcellular, supramolecular or macromolecular structure at a level of resolution below that of the light microscope. The facility is equipped with transmission electron microscopes (TEM) and scanning electron microscope (SEM), as well as the preparative equipment for most biological EM applications. One TEM is a current model equipped for electron tomography and automated montage acquisition.