Chris Bleck

Christopher Bleck, Ph.D.

Core Director

Biography

Christopher Bleck, Ph.D., is the director of the Electron Microscopy Core Facility at the NHLBI.

Research

Research
- Christopher Bleck, Ph.D.

The Electron Microscopy Core provides advice, technical services, training and use of facilities to NHLBI DIR investigators who require electron microscopy (EM) to answer specific research topics. In general, this refers to questions involving subcellular, supramolecular or macromolecular structure at a level of resolution below that of the light microscope. The facility is equipped with transmission electron microscopes (TEM) and scanning electron microscope (SEM), as well as the preparative equipment for most biological EM applications. One TEM is a current model equipped for electron tomography and automated montage acquisition.

Selected Publications

BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.

Authors: Wu K, Seylani A, Wu J, Wu X, Bleck CKE, Sack MN.
Autophagy. 2021 Feb 25;Online ahead of print:

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells.

Authors: Watson MD, Flynn JD, Lee JC.
Biophys Chem. 2021 Feb 01;269:106528

X‐ray microtomosynthesis of unstained pathology tissue samples.

Authors: Nguyen DT, Larsen TC, Wang M, Knutsen RH, Yang Z, Bennett EE, Mazilu D, Yu ZX, Tao X, Donahue DR, Gharib AM, Bleck CKE, Moss J, Remaley AT, Kozel BA, Wen H.
J Microsc. 2021 Jan 22;Online ahead of print:

Nanotomography of lesional skin using electron microscopy reveals cytosolic release of nuclear DNA in psoriasis.

Authors: Lindberg E, Baumer Y, Stempinski ES, Rodante JA, Powell-Wiley TM, Dey AK, Nakajima S, Playford MP, Bleck CKE, Mehta NN.
JAAD Case Rep. 2021 Jan 06;9:9-14