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Cardiovascular Regenerative Medicine

The Laboratory of Cardiovascular Regenerative Medicine, led by Dr. Manfred Boehm, is focused on identifying and better understanding the molecular mechanisms underlying human vascular diseases with the goal of developing new therapeutic approaches.

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Featured Publications

STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations.

Authors: Yu Z, Dmitrieva NI, Walts AD, Jin H, Liu Y, Ping X, Ferrante EA, Qiu L, Holland SM, Freeman AF, Chen G, Boehm M.
Biol Open. 2020 Sep 10;9(9):bio052662
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Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome.

Authors: Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G
J Clin Invest. 2020 Aug 03;130(8):4167-4181
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CRISPR/Cas9-mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell-derived cardiomyocytes.

Authors: Ostrominski JW, Yada RC, Sato N, Klein M, Blinova K, Patel D, Valadez R, Palisoc M, Pittaluga S, Peng KW, San H, Lin Y, Basuli F, Zhang X, Swenson RE, Haigney M, Choyke PL, Zou J, Boehm M, Hong SG, Dunbar CE.
Stem Cells Transl Med. 2020 Jul 23;Online ahead of print:
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Stem Cell-Derived Endothelial Cell Model that Responds to Tobacco Smoke Like Primary Endothelial Cells.

Authors: Chu PH, Chen G, Kuo D, Braisted J, Huang R, Wang Y, Simeonov A, Boehm M, Gerhold DL.
Chem Res Toxicol. 2020 Mar 16;33(3):751-763
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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

Authors: Lalaoui N, Boyden SE, Oda H...Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J.
Nature. 2020 Jan 01;577(7788):
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Research Interests

Research Interests

The Laboratory of Cardiovascular Regenerative Medicine has established the Patient-Centered Vascular Translational Program to conduct research on clinically relevant questions focused on vascular injury, remodeling and repair, and to translate research findings into the development of new therapeutic strategies.

The aims of the Vascular Translational Program align with the principles of precision medicine, investigating how individual variations in genes, environment, and lifestyle contribute to vascular disease. This program was designed to link high-throughput sequencing data with molecular disease mechanisms to facilitate the development of targeted therapies and through this program, we have already successfully identified the genetic cause and/or underlying mechanism of a variety of rare diseases. We are particularly interested in investigating the mechanisms of vascular remodeling triggered by injury or other perturbations such as dysregulated homeostasis, inflammation, calcification or endothelial dysfunction. We believe that improving our understanding of these processes will help us find solutions for disease mitigation and restoring the balance of the relevant biological processes.

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Research Interests

Meet the Team

manfred

Manfred Boehm, M.D.

Senior Investigator

Manfred Boehm received his M.D. in 1993 from the University of Heidelberg, Germany and did his residency in internal medicine at the Franz-Volhard-Clinic, Berlin. Before arriving at the NIH and NHLBI, he was a research fellow at the Max Delbrück Center for Molecular Medicine, Berlin from 1996 to 1997, and the University of Michigan, Ann Arbor from 1997 to 1999. He joined NHLBI as a research fellow in 1999 and has been an Investigator since 2003. Dr. Boehm received a Foundation for Advanced Education in the Sciences Award for Research Excellence from the NIH. He was also the recipient the NHLBI Science Awards in 2015 for his team’s research on rare inherited vascular diseases in children. Since 2018, Dr. Boehm has been the Branch Chief of the NHLBI Translational Vascular Medicine Branch, which focuses on studying vascular disease mechanisms to develop novel treatment strategies to better serve our patients with vascular diseases through genomic and molecular high throughput approaches to help understand diseases processes in common and rare inherited disease populations.

Alessandra

Alessandra Brofferio, M.D.

Clinical Cardiologist
Atul

Atul Mehta, M.D.

Critical Care Fellow
avatar

Cornelia Cudrici, M.D.

Assistant Research Physican
Delong

Delong Liu, M.D.

Staff Scientist
Doug

Douglas Rosing, M.D.

Senior Research Physician
Elisa

Elisa Ferrante, Ph.D.

Staff Scientist
Jacob

Jacob Furcolo

Postbaccalaureate IRTA Fellow
Katherine

Katherine Carney, RN, BSC, CCRC

Research Nurse Specialist
Keron

Keron Navarengom, M.D.

Special Volunteer
Marta

Marta Cardenas

Patient Care Coordinator
Rebecca

Rebecca Harper, Ph.D.

Postdoctoral Visiting Fellow
Rebecca

Rebecca Huffstutler, CRNP

Family Nurse Practioner
Quan

Quan Yu, M.S.

Biologist
Zambia

Zambia Davis

Administrative Assistant
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Videos

NHLBI Orloff Award 2015: Manfred Boehm

Premature CAD Patient