Research

Bioinformatics and Computational Biology Core

Research
- Bioinformatics and Computational Biology Core Research

The Bioinformatics and Computational Biology Core facility at the NHLBI facilitates, amplifies, and accelerates biological and medical research and discovery through the application of the latest bioinformatics methods and technologies. This mission is achieved by delivering high quality and comprehensive support for experimental design, analysis and visualization in a timely fashion. The core is responsive to research scientists’ needs and effectively evolve with advances in the field.

The core services include but are not limited to the following:

  • Statistical analysis including basic statistical analysis, advanced statistical analysis (e.g., linear and generalized mixed model analysis, longitudinal modeling), and custom statistical methods (e.g., tailored to specific research projects)
  • Omics Analysis including: GWAS, Transcriptomics (Microarray and RNA-seq), Genomics (Genome, exome and targeted DNA-seq), Epigenomics (Methyl-seq, ChIP-seq, etc.), Proteomics, and Metabolomics
  • Gene/Target/Disease Analysis: Functional annotation at variant, gene, and geneset level, Interaction Analysis, and Pathway Enrichment Analysis
  • Ad-hoc consultation: Advise on experimental designs, data management and analysis
  • Computing resource development and maintenance, including Bioinformatics Software Development, Systems Toolkits Development, Customized Biological Databases and Web Services Development
  • Training: Personalized training to match user’s specific requirements and group training and workshops

Selected Publications

Identification of human long non-coding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis.

Authors: Ruan X, Li P, Ma Y, Jiang C, Chen Y, Shi Y, Gupta N, Seifuddin F, Pirooznia M, Ohnishi Y, Yoneda N, Nishiwaki M, Dumbovic G, Rinn JL, Higuchi Y, Kawai K, Suemizu H, Cao H.
J Clin Invest. 2020 Oct 13:136336
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Related Labs: Bioinformatics and Computational Biology Core

Danazol Treatment for Telomere Diseases.

Authors: Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS
N Engl J Med 2016 May 19;374(20):1922-31
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Related Labs: Bioinformatics and Computational Biology Core

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma.

Authors: Saba NS, Liu D, Herman SE, Underbayev C, Tian X, Behrend D, Weniger MA, Skarzynski M, Gyamfi J, Fontan L, Melnick A, Grant C, Roschewski M, Navarro A, Beà S, Pittaluga S, Dunleavy K, Wilson WH, Wiestner
Blood 2016 Apr 28
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Related Labs: Bioinformatics and Computational Biology Core

Exome Sequencing of Familial Bipolar Disorder.

Authors: Goes FS, Pirooznia M, Parla JS, Kramer M, Ghiban E, Mavruk S, Chen YC, Monson ET, Willour VL, Karchin R, Flickinger M, Locke AE, Levy SE, Scott LJ, Boehnke M, Stahl E, Moran JL, Hultman CM, Landén M, Purcell SM, Sklar P, Zandi PP, McCombie WR, Potash J
JAMA Psychiatry 2016 Apr 27:
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Related Labs: Bioinformatics and Computational Biology Core
See Also