photo of Dr. Sean Agbor

Sean Agbor-Enoh, M.D., Ph.D.

Lasker Clinical Tenure-Track Investigator

10 Center Dr
Bethesda, MD 20814
United States

703-677-4630

Biography

Dr. Sean Agbor was born and raised in Cameroon, Central Africa. He received his M.D. at the University of Yaounde, Cameroon, after which, through a Fogarty International Center Scholarship, he travelled to Georgetown University Medical Center, Washington DC. There, he completed his Ph.D. and post-doctoral training in Molecular Biology followed by Internal Medicine internship and residency at Johns Hopkins Bayview Medical Center. He also served as Chief Resident in Internal Medicine before completing a joint fellowship in Pulmonary and Critical Care Medicine at the NIH Clinical Center and Johns Hopkins Hospital. He then accepted a clinician scientist position in Dr. Hannah Valantine’s Lab at the NHLBI before applying for and receiving the NIH-Lasker Clinical Research Fellow Award and NIH Distinguish Scholar Award. Currently, he has a joint appointment as a tenure-track investigator at NHLBI Pulmonary Branch and as a lung transplant pulmonary physician at the Johns Hopkins Hospital. His Laboratory of Applied Precision Omics (APO) is based at NHLBI and aims to develop novel approaches to detect and treat transplant rejection.

Research

Research Interests
- Sean Agbor-Enoh, M.D., Ph.D.

APO aims develop novel approaches to detect and treat lung transplant rejection. For children and adult with advanced lung diseases, transplantation is often the only treatment. Unfortunately, half of these patients will die within 5 – 6 years after transplant because of transplant rejection. Transplant rejection is detected by analyzing a biopsy of the transplanted organ. Obtaining biopsy samples require anesthesia and is quite an invasive procedure. Additionally, biopsy has low sensitivity and usually picks up rejection at late stages when treatments options are limited and often with limited benefits. Could early detection and treatment of rejection save the transplanted organ from rejection? The focus of APO is to investigate whether early detection and treatment of rejection improves transplant survival. APO has developed an approach that picks up transplant rejection 2 – 3 months before biopsy. APO is now exploring whether these novel genomic approaches risk stratify other pulmonary patients for long-term outcomes. APO is also planning a clinical trial to assess whether early detection and treatment of rejection improves survival in lung transplant patients and also engaged in additional studies to understand molecular mechanisms of transplant rejection.

Publications