Research

Research
- Animal MRI Core Research

The Animal Magnetic Resonance Imaging (MRI) Core specializes in cardiovascular imaging of mice and rats. We perform all aspects of imaging studies from planning to data analysis and interpretation. We work with investigators to tailor imaging studies to individual study needs. Cardiac function and anatomy, stress testing and vascular imaging are examples of studies performed in the Core; we perform a variety of studies in addition to cardiac imaging. A full list follows. The Core staff facilitates implementation of imaging studies for investigators and teaches interested investigators and fellows. The Core can also incorporate additional imaging modalities through the MIF, such as computed tomography (CT), ultrasound and bioluminescence. Studies are performed in the NIH Mouse Imaging Facility (MIF).

Although the Core is primarily concerned with projects related to cardiovascular imaging in rodents, the team has also worked on more specialized applications, particularly in high resolution microimaging.

Representative studies:

  • Cine imaging for cardiac function
  • Left and right ventricle function (ejection fraction and related parameters), volume, and wall thickness
  • Myocardial infarction imaging
  • Imaging the aorta, pulmonary artery and other vasculature
  • Imaging atherosclerotic plaque
  • Perfusion of skeletal muscle
  • Kidney imaging
  • Whole body imaging to screen for other defects
  • Cellular imaging: magnetic labeling and tracking cell transplants
  • Targeted MRI contrast agent research
  • High resolution imaging of embryos
  • High resolution imaging of fixed tissue
  • Imaging fibrosis in unfixed heart tissue
  • Delayed contrast enhancement imaging

Selected Publications

Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation.

Authors: Beliveau P, Cheriet F, Anderson SA, Taylor JL, Arai AE, Hsu LY
Comput Biol Med 2015 Oct 01;65:103-13

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.

Authors: Holmström KM, Pan X, Liu JC, Menazza S, Liu J, Nguyen TT, Pan H, Parks RJ, Anderson S, Noguchi A, Springer D, Murphy E, Finkel T
J Mol Cell Cardiol 2015 Aug 01;85:178-82

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Authors: Wan W, Liu Q, Lionakis MS, Marino AP, Anderson SA, Swamydas M, Murphy PM
Cardiovasc Res 2015 Jun 01;106(3):478-87

Galnt1 is required for normal heart valve development and cardiac function.

Authors: Tian E, Stevens SR, Guan Y, Springer DA, Anderson SA, Starost MF, Patel V, Ten Hagen KG, Tabak LA
PLoS One 2015 Jan 01;10(1):e0115861

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.

Authors: Furusawa T, Rochman M, Taher L, Dimitriadis EK, Nagashima K, Anderson S, Bustin M
Nat Commun 2015 Jan 01;6:6138